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Biomedical subjects

C Carp

Publications and source records attributed to C Carp.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

Study of cardiovascular and auditory pathophysiological implications in a group of operatives working in noisy industrial surroundings.

One third of 160 operatives working in a permanently noisy industrial environment, within the range of 63-8000 Hz and intensity of sound of about 100 db, were found to suffer from a syndrome of neurocirculatory asthenia and 8.1% from arterial hypertension. Study of the ECG according to the criteria of the Minnesota code showed an increased frequency of upward deflection of ST segment (index 9-2) in 20.6% of the cases, depression of the ST segment with an ascending orientation in 50.62% of the cases and left ventricular hypertrophy (index 3-1 and 3-3) in 20% of the cases. Audiometry revealed loss of hearing at frequencies of 4000 CS in 16.1% of the cases. The results obtained suggest that the detrimental effects are not restricted only to hearing, but also that the alterations detected might evolve towards organic cardiac disorders.

Adult↗
PubMedDate not supplied

Beneficial and adverse effects of atropine in patients with acute myocardial infarction.

The action of atropine on heart rate, prevention of arrhythmias, electrical activity and heart contractility was studied in 35 patients with acute myocardial infarction. Atropine had a favourable effect in 24 out of 27 patients with sinus bradycardia, and hypotension present in some cases was improved. Ventricular extrasystoles observed in 12 patients were suppressed within one hour after atropine administration. A--V block was well influenced in 9 of 16 cases. Nine patients with A--V block, of whom 8 with pump failure, presented arrhythmias after atropine. In 12 patients atropine determined a transient enhancing of the ST segment elevation, caused a persistent increase of the Q wave and altered the systolic time intervals by reducing contractility, with subsequent partial return to initial values. The data obtained justify the use of atropine for the improvement of sinus bradycardia, of arterial hypotension and of A--V block. During the effect of the drug there occurred electrical and contractility changes and, in some patients with pump failure, arrhythmias appeared. These observations demonstrate the necessity of monitoring the patients under atropine treatment and of using small doses, repeated if necessary.

Arrhythmia, Sinus↗
PubMedDate not supplied

Effect of propranolol on experimental periinfarction block and myocardial ischemia.

The effects of propranolol on periinfarction block, myocardial ischemic injury and left ventricular performance following anterior descending coronary artery occlusion were studied. Experiments were made in 14 dogs anesthetized with pentobarbital sodium. Two minutes of reversible myocardial ischemia was induced by occlusion of descending left coronary artery. The severity of myocardial ischemia estimated by summing S-T segment elevation (sigma ST) from epicardial ECG mapping, heart rate, femoral arterial pressure and left ventricular (LV) dp/dt was determined before, during coronary occlusion alone and following propranolol infusion (0.25 mg/Kg) and coronary occlusion. Periinfarction block aspects on epicardial ECG appeared in four dogs following five repeated coronary occlusions. Propranolol infusion before coronary occlusion prevented the periinfarction block in every animal. The decrease of myocardial ischemia (sigma ST elevation), heart rate, arterial blood pressure and LV dp/dt following propranolol and coronary occlusion might be partly due to the beneficial effect of this drug on periinfarction block.

Animals↗
PubMedDate not supplied

Prognostic value of postextrasystolic potentiation in patients with acute myocardial infarction.

To assess the functional reserve of left ventricle and appreciate prognosis in patients with acute myocardial infarction (AMI) showing ventricular premature beats, the systolic time intervals (STI) and the apexcardiogram (ACG) were determined in sinus rhythm and at the first postextrasystolic beat in 30 patients with AMI (12 mens, 18 women, average age 49 years), distributed into the first three functional classes (Killip), 10 in each class. Location of AMI was anterior in 21 cases, inferior in 1 and anteroinferior in 8. At the first postextrasystolic beat, class III patients showed a lengthening of PEP interval and increase of the PEP/LVET ratio, compared to those in initial sinus rhythm, thus indicating an absence of potentiation; ACG tracings in the same group revealed a lengthening of isovolumic relaxation time (IRT). In classes I and II, both the STI measurement and ACG data indicated the presence of potentiation at the first postextrasystolic beat, manifested by PEP shortening and decrease of PEP/LVET ratio, as well as by a reduction of IRT. Of the patients in classes I and II, only one developed heart failure, while of class III patients, 4 died of heart failure within one year and 3 showed cardiogenic shock on admission. The absence of potentiation in the latter category (with congestive heart failure) is interpreted as a sign of severe prognosis for the subsequent course and outcome of AMI.

Adult↗
PubMedDate not supplied

Value of the electrocardiographic stress test by atrial pacing in the healing stages of experimental myocardial infarction.

To check up the value of atrial pacing (AP) in estimating the degree of healing in myocardial necrosis, an ECG study was carried out in 20 dogs with experimental myocardial infarction induced by ligation of the left descending coronary artery. The main ECG changes recorded after ligation i.e., Q waves in 14 animals (73%), S-T segment elevation in 14 (74%) and decrease of QRS voltage in 12 (63%), disappeared within a 7-day interval. Anesthesia with Nembutal 56--57 days after ligation and before AP application induced the occurrence of Q waves in 6 animals, S-T segment depression in 18 and T wave inversion in 12. AP during 20 minutes, at a heart rate of 200 beats/min, produced the appearance or the increase of S-T segment depression in 14 animals and T wave inversion in 12. These findings support the assumption that the AP stress test can be used for the evaluation of the necrosis degree in the healing stages of experimental myocardial infarction, but a correct interpretation of the ECG changes induced by AP should also take into account the previous abnormalities due to anesthesia.

Animals↗
PubMedDate not supplied

Changes of human platelets studied by scanning electron microscopy in acute myocardial infarction.

The formation of platelet aggregates has been suggested to be the initial step in coronary occlusion and the subsequent myocardial infarction (AMI). By scanning electron microscopy we followed: the platelet morphology and aggregation, the macrophage (M) morphology and the lymphocyte (T, B) count and structure in 11 patients with AMI and in 18 patients with unstable angina (UA). Generally, in the patients with AMI, most of the platelets presented relatively frequent (42.5%) or very frequent pseudopodia (35.27%) and the network of surface extensions was associated with several huge platelet aggregates in 6 patients. The mean lymphocyte count was: T = 40.36 +/- 23.95%; B = 28.09 +/- 7.38%; M = 31.54 +/- 21.25%. In the patients with unstable angina the proportion of platelets with pseudopodia was more reduced, namely, that of platelets with relatively frequent pseudopodia was 33.8% and with very frequent pseudopodia was 27.8%. The mean lymphocyte count was: T = 40.30 +/- 20.24%; B = 34.6 +/- 14.39%; M = 25 +/- 10.50%. These data indicate that platelet changes and the formation of aggregates can be an important factor in the occurrence of AMI. The change of immunocompetent cell count in both groups of coronary patients suggests the association of an immunologic process in coronary atherosclerosis.

Adult↗
PubMedDate not supplied

Prognosis of acute myocardial infarction using systolic time intervals recorded on the carotidogram.

The prognostic value of systolic time intervals and of other clinical and laboratory parameters was investigated in 68 patients with acute myocardial infarction (AMI) (55 males and 13 females; mean age 61 years) over a period of one month after onset of the disease. The statistical analysis of data was made by the STR stepwise regression method, using an IBM--360 computer. Finally the study resulted in a stepwise multiple regression equation with 4 factors of maximum statistical significance in the prognosis of AMI: peak SGOT level, age of patients, uncorrected left ventricular ejection time and index of preejection period. This new prognostic index allows a classification of patients with acute myocardial infarction (starting with the second day after onset) into groups of various severity, thus helping the practitioners in the choice of therapy.

Age Factors↗