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C Carp

Publications and source records attributed to C Carp.

43 records · Page 3Linked to original sources
PubMedDate not supplied

Prognosis of acute myocardial infarction using systolic time intervals recorded on the carotidogram.

The prognostic value of systolic time intervals and of other clinical and laboratory parameters was investigated in 68 patients with acute myocardial infarction (AMI) (55 males and 13 females; mean age 61 years) over a period of one month after onset of the disease. The statistical analysis of data was made by the STR stepwise regression method, using an IBM-360 computer. Finally the study resulted in a stepwise multiple regression equation with 4 factors of maximum statistical significance in the prognosis of AMI: peak SGOT level, age of patients, uncorrected left ventricular ejection time and index of preejection period. This new prognostic index allows a classification of patients with acute myocardial infarction (starting with the second day after onset) into groups of various severity, thus helping the practitioners in the choice of therapy.

Adult↗
PubMedDate not supplied

Study of the immune state in patients with a history of subacute bacterial endocarditis and in their direct relatives. Pathogenic implications.

Immunologic investigations were performed in 18 patients at a mean interval of 1.8 years after cure of subacute bacterial endocarditis (SBE) and in 17 of their direct relatives. The results were compared with those obtained in a control group of 52 healthy subjects. Assay of serum immunoglobulins revealed deviations from the normal (mean +/- 2 SD) in 65% of the post-SBE patients and in 77% of their relatives. Tests for the presence of nuclear, smooth muscle, mitochondrial, cytoplasmatic, albumin and interstitial antibodies showed the presence of such autoantibodies, either single or associated, in 55% of the post-SBE patients and in 58% of their relatives. The serum complement titer was low in 54% of the former SBE patients and in 66% of their relatives. A series of antimicrobial skin tests or intradermal reaction to dinitrochlorobenzene showed hypergy or anergy in 54% o the post-SBE patients investigated. These results, alongside with the data in the literature, support the hypothesis of the preexistence of the immune deficit (probably inherited) in the cardiac patients who develop SBE.

Adult↗
PubMedDate not supplied

Effects of verapamil on the acute experimental myocardial ischemia.

The hemodynamic effects of verapamil in conditions of myocardial ischemia and its influence on the atrio-ventricular conduction were investigated in 13 dogs with transient repeated occlusions of the anterior descending coronary artery. Verapamil 0.25 mg/kg was administered after control determinations of heart rate, LV dp/dt, systolic and diastolic arterial pressure and the mean sum of S--T segment elevations recorded by means of 9 epicardial electrodes. Comparison of the differences between the control data and those after occlusion, on the one hand, and those before and after occlusion + verapamil, on the other hand, showed that the drug did not induce significant hemodynamic changes. Arterial pressure was slightly lowered; the increase of LV dp/dt noted after occlusion without verapamil did not occur any more and the S-T segment and T wave disturbances were also less marked, suggesting a protective effect on the ischemic lesion. Larger doses of verapamil (0.50-0.75 mg/kg) induced second and third degree A-V blocks in three animals. These effects could be controlled in two animals by previous or subsequent administration of Carbocromen.

Acute Disease↗
PubMedDate not supplied

Value of systolic time intervals in the estimation of heart failure secondary to acute myocardial infarction.

Serial measurements of left ventricular systolic time intervals (STI) were carried out in 44 patients with acute myocardial infarction (AMI) in the first 5 days after onset, by indirect methods. The patients with heart failure showed significant decreases of ejection time (ET) (p less than 0.001) and of the ejection time index (p less than 0.005) and increases of Wiessler's ratio (PEP/ET) (p less than 0.001). The pre-ejection period (PEP), the isovolumetric contraction time and the total electromechanical systole were unsignificantly changed. Ejection time was shorter than 250 msec in the patients with acute pulmonary edema or congestive heart failure, in most of the patients with flutter or atrial fibrillation and in 16 of the 17 patients who died. Ejection time may have a prognostic significance and may be useful in the early detection of heart failure in AMI. The changes of STI after administration of lanatosid C show the positive inotropic effect of this drug in patients with AMI.

Adult↗
PubMedDate not supplied

Electrocardiographic diagnosis of experimentally-induced myocardial infarction during cardiac electrostimulation.

The sequential ECG changes were studied by the Sodi-Pallares' method in 10 dogs before and after experimentally induced myocardial infarction of the left ventricle during right and left artificial stimulation. Right ventricular endocardial stimulation produced patterns of left bundle branch block in 9 dogs and of right bundle branch block in one, while left ventricular stimulation caused right bundle branche block patterns in 9 animals. Records during right ventricular stimulation after myocardial infarction showed in the peripheral leads myocardial necrosis only in two animals, while in the epicardial leads necrosis was certain in 2 animals (Q wave) probable in 6 (S-T segment elevation) and suggestive in 2 (T wave negatively). Myocardial necrosis during left ventricular stimulation was evident in the peripheral leads in 2 animals, probable in 6 and suggestive in one. The experimental data suggest that myocardial necrosis can be diagnosed in some cases during right and left ventricular artificial stimulation.

Animals↗
PubMedDate not supplied

Electrocardiographic diagnosis of myocardial infarction in patients with pacemakers.

The ECG changes of myocardial infarction during permanent or transient right ventricular pacing were studied in 32 patients with transvenous pacemakers who developed myocardial infarction. During right ventricular pacing the electrocardiogram resembled left bundle branch block in 29 patients, right bundle branch block in two, and in one patient the pattern could not be determined. Myocardial infarction induced new ECG changes during pacemaker rhythm in 20 of the 32 patients. There were only QS complexes in 5 cases, ST segment abnormalities in 4 and T wave inversions in 4, negative Q and T waves were simultaneously observed in one patient, Q wave and S-T segment changes in 3 and S-T segment change and T wave inversion in 3 patients. It is concluded that knowledge of the ECG changes induced by myocardial infarction in most patients under artificial pacing can be useful for diagnosis.

Adult↗