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C Castro

Publications and source records attributed to C Castro.

At least 109 records · Page 6Linked to original sources
PubMed1990

Trypanosoma (Schizotrypanum) cruzi: repetitive DNA sequence evolution in three geographically distinct isolates.

1. Middle-repetitive DNA sequences were analyzed by molecular hybridization to determine both the extent of complementarity and time of evolutionary divergence between isolates of Trypanosoma cruzi from Argentina, Mexico, or Venezuela. 2. Although molecular hybridizations showed no significant difference between the middle-repetitive DNAs of the Mexican and Venezuelan isolates, there was a 2.7% base pair mismatch in hybrid molecules formed by association of strands from both the Mexican and Argentine isolates. 3. Using the rates for divergence of middle-repetitive DNA in sea urchins, the Mexican and Argentine isolates were estimated to have diverged approximately 20-25 million years ago. 4. Analysis of the kinetics for the DNA hybridizations indicates that only minor amplifications of specific gene sequences or changes in the complexity of the genomes could have occurred during the divergence of the three isolates studied.

Animals↗
PubMed1990

Normative data on the Boston Diagnostic Aphasia Examination in a Spanish-speaking population.

Normative data of the Boston Diagnostic Aphasia Examination (Goodglass & Kaplan, 1972) in a Spanish-speaking population is presented. This test was given to 180 neurologically normal adults grouped according to three variables: sex, age, and educational level. The statistically significant differences found are presented. Few differences appeared between sexes, but there were marked differences among the different age groups and in particular among educational levels. A correction to the scoring is proposed for each of the subtests according the patient's educational level.

Adolescent↗
PubMed1990

Treatment of transitional cell carcinoma of the ureter: is the controversy justified?

Between 1938 and 1985, 73 patients with ureteral tumors underwent surgery at Puigvert Foundation (1 case with bilateral synchronous tumors). Sixty-three patients were males and 10 females. Ages ranged between 49 and 78 (mean of 62) years. Tumoral stages were: pTa 5 cases; pT1 56 cases; pT2 10 cases, and pT3 2 cases. Radical treatment was performed in 38 cases and conservative treatment in 35 cases. Follow-up ranged between 2 and 20 (mean of 7) years. The overall survival rate at 5 years was 100, 82 and 50% for stages pTa, pT1 and pT2-3, respectively (p less than 0.05). Analyzed together, the actuarial survival at 5 years was 90.3% with conservative surgery and 67.8% with radical surgery (p not significant). The survival by stages for the patients treated with radical surgery was: 100% in pTa; 69.6% in pT1, and 57.1% in pT2-3. For those treated conservatively, survival was 100% in pTa, 95.8% in pT1 and 33.3% in pT2. Thus patients presenting with infiltrating tumors should not be treated conservatively, while patients with superficial lesions had a similar evolution whether treated by conservative or radical surgery.

Carcinoma, Transitional Cell↗
PubMed1989

[Clinical trial of the use of the combination of piracetam and dihydroergocristine in vertigo from different causes].

We report on the therapeutic effect of a combination of piracetam and dihydroergocristine in 55 vertiginous patients, of both sexes, between 20 and 67 years of age, from different causes (not scheduled for surgery). The trial lasted 3 months, and the drugs were taken twice daily. Aside from one case who stopped the drug therapy because of intolerance, the conclusions drawn by the AA. are seemingly good, both subjectively and objectively (audiometric and electronystagmographic tracings).

Adult↗
PubMed1989

[Non-fatal firearm injuries of the head and neck].

There is depicted the evolutive course of 6 men with gunshot wounds of the neck and head, fortunately not threatening their lives. All victims were men between 18 and 67 years of age. Three times the gun fired a single projectile, whereas the other 3 were multiple projectiles. The latter cases resulted in heavier damages. Etiologically the events were classified as: 3 cases as suspected murder, 2 as attempted suicide and in the last case, an accident. The management has been both medical and surgical under general anesthesia, in order to repair the disorders and/or remove the bullets in 5 occasions. The sixth case did not allow removal of the bullet because of expected risk. All the cases did seemingly well, in spite of 2 who had postoperative complications which delayed healing.

Accidents↗
PubMed1988

Genomic DNA sequence polymorphism of Trypanosoma (Schizotrypanum) cruzi isolates with phenotypic variation.

1. Single-copy DNA sequences were analyzed by molecular hybridization to determine both the extent of complementarity and time of evolutionary divergence between three isolates obtained from Argentina, Mexico or Venezuela. 2. The Mexico-Venezuela pair appeared much closer than the Mexico-Argentina pair. 3. The tentative values for time of evolutionary divergence were higher than those estimated previously by allozymic variation.

Animals↗
PubMed1987

[Supplementation of maternal milk with calcium and phosphorus for the feeding of premature neonates weighing 1500 g or less. How long should it be continued?].

Feeding four preterm infants weighing less than or equal to 1,500 g with human milk supplemented with calcium (160-200 mg/kg/day) and phosphorus (80-200 mg/kg/day) until term postmenstrual age was reached, and suitable levels of plasma calcium, phosphorus and alkaline phosphatase and urinary excretion index of calcium and phosphorus were attained. When such a supplementation was suppressed at 38-40 weeks of postmenstrual age a rapid onset of biochemical disturbances was observed: a rise of plasma calcium (p less than 0.025) and alkaline phosphatase (p less than 0.0025) with a decrease of plasma phosphorus (p less than 0.005) and of urinary phosphate excretion (p less than 0.002). Reincorporation to former supplemented regime results in quick recovery of these parameters. Authors can assert that the necessity of calcium and phosphorus supplementation of human milk for less than or equal to 1.500 g preterm infant feeding exceeds the term postmenstrual age if suitable calcium and phosphorus levels are to be obtained.

Alkaline Phosphatase↗
PubMed1986

[Regional organization of a neonatal transportation system].

Organization, operational plans, and initial experience of a Regional Neonatal Transport System is described. The system covers provinces of Bizcaia, and Alava in Northern Spain, with a total of 17,500 annual deliveries. In the first 10 months 31 newborn infants were transported. Their mean birth weight was 2,066 +/- +/- 931 Gm. Ten infants had a birth weight less than 1,500 Gm, and in 22 (71%) of them gestational age was under 37 weeks. Some types of respiratory distress was present in 71% of them, and 25.8% required mechanical ventilation during transport. Hypothermia was present in 36% of the infants at referral center, percentage that decreased to only 9% at their arrival to the NICU. During transport mean body temperature increased from 35.33 +/- 1.07 degrees to 35.84 +/- 0.9 degrees C (p less than 0.01). Infants condition was judged to improve in 13% of them. Overall survival rate was 74.2%, being 80.9% in those weighting from 1,000 to 1,500 Gm. Infants who were hypothermic had a lower survival (45.5%) than those who were not (90%) (p less than 0.05).

Birth Weight↗
PubMed1985

[Disappearance of tardive dyskinesia in a manic attack].

A 66 year-old man suffered of a manic-depressive illness. Tardive dyskinesia appeared after a treatment with chlorpromazine. Abnormal movements were present at normal and depressive states, but disappeared during manic phases. A few similar cases have been reported. The authors suggest that a modification in the sensibility of monoaminergic receptors could explain the disappearance of dyskinetic movements during mania.

Aged↗
PubMed1983

Immunoglobulins and other serological parameters in Chagas' disease: evidence for increased IgA levels in the chronic digestive form.

Immunoglobulin levels were measured in serum samples from 36 patients with different clinical forms of chronic Chagas' disease. Increased IgA levels were observed in 50% of the patients in the chronic digestive group and there was a significant correlation with the severity of the disease. IgG and IgM levels were within the normal range. Anti-ssDNA antibodies and EVI (endothelium, vessels and interstitium) antibodies were found in some patients with different clinical forms of the disease.

Autoantibodies↗
PubMed1982

Desialylation of fibrinogen with neuraminidase. Kinetic and clotting studies.

The removal, with time, of sialic acid residues from human fibrinogen by neuraminidase, can be explained, as a result of a mathematical analysis, by the summation of two first order reactions with clearly different rate constants. Quantitative studies on the bound sialic acid to isolated fibrinogen chains, after reduction and alkylation of the partially desialylated fibrinogen, show that the fast reaction takes place with the sialic acid bound to the B beta chains. This indicates that the carbohydrate located in the gamma chains is somehow protected or less accessible to the enzyme. Coagulation with thrombin of desialylated fibrinogen shows that the aggregation rate increases linearly as the amount of sialic acid residues decreases, regardless of their location in the fibrinogen molecule.

Blood Coagulation↗
PubMed1981

Genome organization and ploidy number in Trypanosoma cruzi.

Trypanosoma cruzi total DNA was analyzed by DNA:DNA reassociation kinetics. The nonlinear least-squares computer solution could reasonably be fitted to three second-order kinetic components. The highly repetitive, middle repetitive, and single copy components comprised 9, 35 and 49% of the genome, respectively. The single copy sequences showed a kinetic complexity of approximately 4 times that of Escherichia coli and of some 11,000 average-sized structural genes. The repetitive sequences (about 6900) presented the long-period pattern of interspersion with a modal length of 7800 bases. The kinetic complexity of total DNA was compatible with a value of at least a diploid genome per cell.

Animals↗
PubMed1981

Skin reactions to bug bites as a result of xenodiagnosis.

Cutaneous allergic reactions to bites of two bug species Triatoma infestans and Dipetalogaster maxima, were studied in an area where T. infestans is the local domestic vector. While more delayed skin reactions occurred with the indigenous vector, reactions also occurred with D. maxima. Repeated exposure to D. maxima produced more intense immediate skin reactions. First-stage D. maxima bugs produced a lower frequency and intensity of skin reaction. It is concluded that further work on this problem is necessary as it prejudices the use of xenodiagnosis in field surveys.

Animals↗