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Biomedical subjects

C Commens

Publications and source records attributed to C Commens.

At least 19 recordsLinked to original sources
PubMed1999

Radiation-induced localized scleroderma in breast cancer patients.

Radiation-induced scleroderma in breast cancer patients appears to occur in approximately one out of every 500 patients. We report four cases that developed within 3 months of conservative breast surgery and postoperative radiation treatment. The reaction was contained entirely within the treatment field and demonstrated the typical features of this condition where the breast becomes erythematous, violaceous, indurated, retracted, and progressively pigmented. The breast tends to soften and become more comfortable over 1-4 years; however, significant induration, retraction and pigmentary changes remain. There appears to be no predictive factors. Radiation-induced scleroderma must be differentiated from cellulitis and recurrent breast cancer.

Adult↗
PubMed1991

Lentinginous dysplastic naevi in the elderly: a potential precursor for malignant melanoma.

Seventy-seven skin biopsies diagnosed histologically as lentiginous junctional naevi from individuals aged over 60 years were reviewed. Seventy-three specimens showed a primarily nested pattern with disordered arthitecture concentrated within the rete ridges conforming to the pathology of a lentiginous dysplastic naevus. In 28 biopsies this was combined with a melanoma in situ. The latter was reflected by a focal loss of the rete ridge system, confluent melanocytic hyperplasia and single cell invasion of the epidermis by atypical malanocytes. Four biopsies showed lentiginous junctional naevi with only isolated naevus cell nests without a disordered architecture or cellular atypia. Thirty-seven of the 57 naevi in men were located on the back in contrast to 5 of the 20 women. In women the lower limb was the most frequent site with 8 of the 20 lesions originating at this site in contrast to 1 of the 57 men. The pathological diagnosis of dysplastic lentiginous naevi in the elderly needs to be recognised as having a high association of melanoma-in-situ changes.

Aged↗
PubMed1991

Disseminated superficial actinic porokeratosis. A histological review of 61 cases with particular reference to lymphocytic inflammation.

The pathology of 61 cases of disseminated superficial actinic porokeratosis was reviewed and the relative frequency of the histological features associated with the cornoid lamella and the pathology within and outside the porokeratotic rim were assessed. Papillary dermal lymphocytic infiltrate (97%), spinous layer vacuolar changes (90%), dyskeratotic cells in the epidermis (77%), and liquefaction degeneration of the basal layer (67%) were frequently seen under the cornoid lamella. Papillary lymphocytic infiltration was seen more frequently inside the porokeratotic ring in comparison to the outer skin. Lymphocyte marker studies in nine cases showed a predominance of activated T lymphocytes with positive LN3 and UCHL-1 staining. Together with the finding of a lichenoid reaction pattern, these results lend support to the hypothesis that actinic porokeratosis represents a migrating clone of abnormal keratinocytes with an associated immunological host response.

Atrophy↗
PubMed1990

Dermatomyositis associated with multifocal lipoatrophy.

A 10-year-old boy had juvenile dermatomyositis and multiple asymmetric lesions of lipoatrophy. The lipoatrophy had occurred without preceding clinical evidence of inflammation. Biopsy specimens of the skin confirmed a lobular panniculitis. This is the first report of the association of lipoatrophy and juvenile dermatomyositis.

Buttocks↗
PubMed1989

Epidermal nevi and the epidermal nevus syndrome. A review of 131 cases.

One hundred thirty-one patients with epidermal nevi are reviewed. The commonest site of involvement was the head and neck, and 13% of patients had widespread lesions. Ages of onset ranged from birth to 14 years. A spread beyond the original distribution was noted in 37% of patients. Many clinical patterns occurred, including eight cases of inflammatory linear verrucous epidermal nevus. A variety of other cutaneous abnormalities were found. Biopsies were performed in 41 cases. Three patients developed secondary tumors. One hundred nineteen of the patients were assessed for the presence of abnormalities in other organ systems. One or more abnormalities were demonstrated in 33% of patients, and in 5%, five or more abnormalities were detected. This study indicates that patients with epidermal nevi are at significant risk of having other abnormalities and warrant detailed initial assessment and close follow-up.

Age Factors↗
PubMed1989

Heterotropic brain tissue presenting as bald cysts with a collar of hypertrophic hair. The 'hair collar' sign.

We report the cases of two children who were each noted at birth to have a single bald compressible nodule on the scalp that was surrounded by a collar of hypertrophic hair. One of the mothers had taken doxylamine succinate during pregnancy. Extensive investigations and, finally, surgery revealed that the lesions were heterotropic brain tissue without connection to the brain. Encephaloceles may also have a "hair collar." The presence of a hair collar around any cutaneous lesion should alert the clinician to the possibility of a neuroectodermal defect. All procedures on these lesions should be delayed until appropriate investigations have excluded any connection with the underlying nervous system.

Brain↗
PubMed1988

Collodion babies with Gaucher's disease.

Two neonates with acute infantile cerebral Gaucher's disease had prominent collodion skin. Ichthyosis has been described in some cases of metabolic lipid disorders, however, this is the first report of the association of lamellar desquamation of the newborn (collodion baby) with Gaucher's disease.

Brain Diseases, Metabolic↗