Urinary urea nitrogen prediction of total urinary nitrogen.
Explore the source record for details and available documents.
Humans↗
Biomedical subjects
C Coudray-Lucas
Publications and source records attributed to C Coudray-Lucas.
Effects of norepinephrine on hepatic amino acid metabolism in isolated perfused rat liver.
The effects of norepinephrine (NE) on hepatic amino acid exchanges were studied in the isolated perfused rat liver using a recirculating system with a medium containing amino acids at twice physiologic concentrations. Norepinephrine induced a significant decrease (25%) in portal blood flow at a concentration of 2 ng/ml (10(-8) M). The hormone also increased total hepatic amino acid uptake, essentially through a switch from glutamine release to net uptake. There was no modification in free intracellular amino acids, but glycogen was slightly decreased, and glucose production was increased. Taken as a whole, these results suggest that NE modulates hepatic protein balance.
Amino Acids↗
Fate of enterally administered ornithine in healthy animals: interactions with alpha-ketoglutarate.
In order to improve our understanding of the metabolic interactions between alpha-ketoglutarate (alpha KG) and ornithine (Orn), which constitute the two parts of ornithine alpha-ketoglutarate (OKG) used as an adjuvant in enteral nutrition, we have investigated the plasma appearance and tissue distribution (qualitative and quantitative) of enterally administered 14C-Orn and 14C-alpha KG in healthy mice and rats. The influence of unlabelled alpha KG or Orn on 14C-Orn or 14C-alpha KG metabolism, respectively, was also studied. Unlabelled alpha KG was able to reduce strongly the rate of intestinal absorption of 14C-Orn, whereas the inverse was not true. This alpha KG-induced loss in plasma radioactivity after a load of Orn was associated with a decrease of radioactivity in tissue with no modification of the qualitative distribution in organs. In this study, a direct interaction between alpha KG and Orn was demonstrated at the intestinal level. The mechanisms involved in this phenomenon probably involve the regulation of metabolic conversions among alpha KG, Glu, pyrroline-5-carboxylate, and Orn. This is of importance in the therapeutic use of ornithine salts in clinical nutrition.
Animals↗