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Biomedical subjects

C Desaive

Publications and source records attributed to C Desaive.

At least 37 records · Page 2Linked to original sources
PubMed1991

Tumor IGF-II content in a patient with a colon adenocarcinoma correlates with abnormal expression of the gene.

We have recently reported abnormal insulin-like growth factor-II (IGF-II) mRNA levels in a number of human colorectal adenocarcinomas. Using an IGF-II radioimmunoassay, we have now detected high levels of both 10-kDa and 7.5-kDa IGF-II species (2,370 ng/g) in a right colon tumor showing a 800-fold IGF-II gene over-expression in comparison to the normal adjacent tissue. The higher-molecular-mass form represents 74% of the total immunoreactive IGF-II detected in the tumor. This form appears to be less reactive in the radioreceptor assay than in the radioimmunoassay. The insulin-like growth factor-I (IGF-I) concentration in the tumor is low. The patient's pre-operative serum IGF-II level is not increased and the proportion of the 10-kDa species is normal. In addition, the IGF-II/IGF-I ratio is 3 in the serum and 308 in the tumor. Our results show that the very high IGF-II level produced by the tumor does not influence the seric concentration of the growth factor.

Adenocarcinoma↗
PubMed1989

Operative mortality following surgery for colorectal cancer.

From 1973 to 1986 at the Baviere Hospital, University of Liège, 476 patients underwent surgery for colorectal cancers. The overall operative mortality rate was 13.4 per cent. The following postoperative life-threatening complications occurred: myocardial infarction (14 per cent of the postoperative deaths) during the first three postoperative days; bronchopneumonia (27 per cent of the postoperative deaths) mainly during the first postoperative week; pulmonary embolism (17 per cent of the postoperative deaths) mainly during the second postoperative week; anastomotic leakage and cerebrovascular accident (14 and 8 per cent of the postoperative deaths respectively) mainly during the third and fourth postoperative weeks. Specific risk factors were chronic obstructive airways disease associated with a higher incidence of postoperative bronchopneumonia, and previous myocardial infarction associated with postoperative myocardial infarction and pulmonary embolism. General risk factors were old age and emergency procedure, both of which were associated with a higher incidence of infectious complications. The operative mortality rate fell from 20.1 per cent in the 1973-79 period to 7.8 per cent in the 1980-86 period.

Age Factors↗
PubMed1989

Diagnostic and treatment of rectal cancer.

The authors briefly describe different aspects of rectal cancer: epidemiology, etiological factors, screening procedures, pathology, tumor spread and clinical classification.

Colonoscopy↗
PubMed1988

Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC).

A randomized clinical trial was conducted by the European Organization for Research and Treatment for Cancer (EORTC) Gastrointestinal Cancer Cooperative Group to study the effectiveness of irradiation therapy administered in a dosage of 34.5 Gy, divided into 15 daily doses of 2.3 Gy each before radical surgery for rectal cancer (T2, T3, T4, NX, MO). Four hundred sixty-six patients were entered in the clinical trial between June 1976 and September 1981. Tolerance and side effects of preoperative irradiation were acceptable. The overall 5-year survival rates were similar in both groups. When considering only the 341 patients treated by surgery with a curative aim, the 5-year survival rates were 59.1% and 69.1% in the control group and in the combined modality group, respectively (p = 0.08). The local recurrence rates at 5 years were 30% and 15% in the control group and the adjuvant radiotherapy group, respectively (p = 0.003). Although this study did not show preoperative radiotherapy to have a statistically significant benefit on overall survival, it does have a clear effect on local control of rectal cancer. Therefore, before performing radical surgery, this adjuvant therapy should be administered to patients who have locally extended rectal cancer.

Adenocarcinoma↗
PubMed1986

[Submucous hematoma of the cecum under anticoagulant therapy].

A patient developed an intramural hematoma of cecum as a result of indirect anticoagulant treatment. The case is remarkable with respect to the symptomatology and the very restricted extension of the lesion, these features probably resulting from a process of secondary infection.

Acenocoumarol↗
PubMed1984

Antimitotic activity of strychnopentamine, a bisindolic alkaloid.

Strychnopentamine has been tested for its cytotoxic and antitumor activities and compared with two other bisindolic alkaloids that possess an usambarane skeleton. The presence of a N-methylpyrrolidine group increases the antimitotic activity of this type of alkaloids.

Alkaloids↗