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Biomedical subjects

C Dostál

Publications and source records attributed to C Dostál.

At least 19 recordsLinked to original sources
PubMed1992

[Systemic lupus erythematosus and pregnancy. Present status].

The authors summarize contemporary views on the relationship between pregnancy and systemic lupus erythematosus (SLE) in women of reproductive age. It is known that pregnancy influences in a marked way the basic disease and conversely the disease has an impact on the course of pregnancy. Risks ensuing from these in errelations for women--mothers with SLE and the foetus are exacerbation (flare-up) of the basic disease, loss of the foetus and damage of the foetus by so-called "lupus neonatorum" with skin symptoms and complete cardiac A-V block. The contemporary state of knowledge makes it possible under certain conditions to achieve by therapeutic interventions the development and delivery of a healthy foetus. Among these views it is most important for conception to occur in these patients with SLE during a period without signs of active SLE. To ensure a successful course of pregnancy in women with SLE is the task of a team of appropriate specialists.

Female↗
PubMed1990

[Rheumatology today and yesterday. Modern advances and future trends].

The author mentions some recent advances from the sphere of clinical medicine and associated theoretical disciplines which may closely influence the future development of rheumatology. In addition to technical advances as regards visualization of tissue structures such as magnetic resonance and the development of artificial prostheses of damaged joints, molecular biology and genetics are the greatest advance as regards knowledge of the aetiopathogenesis of disease in particular those which have an immunopathological background.

Humans↗
PubMed1990

[Antibodies against deoxyribonucleoproteins in circulating immune complexes in the blood of patients with autoimmune diseases].

In 40 patients with various autoimmune diseases antibodies against desoxyribonucleoprotein (DNP) were assessed by enzyme immunoanalysis (ELISA) in serum and after dissociation of the isolated precipitate of circulating immune complexes (CIC) in the presence of polyethylene glycol. The results indicate that antibodies against DNP are not specific for systemic lupus erythematosus (SLE) and can be detected in serum and in particular in CIC in various autoimmune conditions. In SLE they may be important for evaluation of the activity of the disease, in particular if estimated concurrently in serum and in CIC.

Antigen-Antibody Complex↗
PubMed1990

[Why are there anti-cardiolipin antibodies in patients with infectious mononucleosis and in patients with systemic lupus erythematosus?].

The phenomenon of anticardiolipin antibodies (aCL) is in recent years the subject of interest as it is connected with manifestations of thromboses at different sites, with repeated miscarriages in pregnant women and with thrombocytopenia. As compared with the original finding in patients with systemic lupus erythematosus (SLE), the authors find they are present also in infection with the Epstein-Barr virus--in patients with acute infectious mononucleosis, in as many as 61% of a total number of 77 examined patients; in a group of 60 patients with SLE in 41% and in a group of healthy controls in 3.9%. aCL differ, however, as regards the distribution of isotypes--aCL of class IgM are found mainly in infectious mononucleosis, class IgG in patients with SLE. The authors discuss problems associated with the development and practical importance of these antibodies.

Adolescent↗
PubMed1987

Preliminary results of an epidemiological study of back pain in a Prague population.

The authors present the preliminary results of an ongoing epidemiological study designed to determine the prevalence of back pain at selected worksites of Czechoslovak State Railways and Avia Letnany, an industrial plant. Examination of a total of 1,555 subjects was conducted by a field team of health-care workers of the Research Institute of Rheumatic Diseases based in Prague. The examination included a detailed medical history, physical examination and, in some probands, the results of HLA B 27 antigen determination, and x-ray examination. Overall, the prevalence of back pain in the cohort was 67%, with 63% and 76% in men and women, respectively. First complaints of back pain are most frequently reported by subjects in their 20s and 30s. The highest prevalence rate was registered in persons aged 50. The pain, as a symptom of a broad spectrum of pathological states, was most often localized in the lumbar and cervical segments of the spine -- 71% and 32%, respectively. In terms of the professions studied, the lowest prevalence was found in a group of manual workers employed at some worksites of the AVIA factory, with the highest frequency of back pain observed in an inconsistent group of diverse jobs, mostly requiring minimal training. In the Discussion section, the authors compare their results with those reported by some other studies published abroad.

Adolescent↗