Biomedical subjects
C Dostál
Publications and source records attributed to C Dostál.
[Why are there anti-cardiolipin antibodies in patients with infectious mononucleosis and in patients with systemic lupus erythematosus?].
The phenomenon of anticardiolipin antibodies (aCL) is in recent years the subject of interest as it is connected with manifestations of thromboses at different sites, with repeated miscarriages in pregnant women and with thrombocytopenia. As compared with the original finding in patients with systemic lupus erythematosus (SLE), the authors find they are present also in infection with the Epstein-Barr virus--in patients with acute infectious mononucleosis, in as many as 61% of a total number of 77 examined patients; in a group of 60 patients with SLE in 41% and in a group of healthy controls in 3.9%. aCL differ, however, as regards the distribution of isotypes--aCL of class IgM are found mainly in infectious mononucleosis, class IgG in patients with SLE. The authors discuss problems associated with the development and practical importance of these antibodies.
Anticardiolipin antibodies in infectious mononucleosis.
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Prevalence of back pain in a sample of Czechoslovak industrial population. Preliminary results of an ongoing study.
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[Statistical analysis of immunogenetic models].
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[HLA-B27 antigen in the nonspecific back pain type of spondylopathy].
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[The role of Epstein-Barr viruses in the etiopathogenesis of rheumatoid arthritis].
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[Antibodies against capsid (VCA) and nuclear (EBNA) antigens of the Epstein-Barr virus in patients with rheumatoid arthritis].
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Preliminary results of an epidemiological study of back pain in a Prague population.
The authors present the preliminary results of an ongoing epidemiological study designed to determine the prevalence of back pain at selected worksites of Czechoslovak State Railways and Avia Letnany, an industrial plant. Examination of a total of 1,555 subjects was conducted by a field team of health-care workers of the Research Institute of Rheumatic Diseases based in Prague. The examination included a detailed medical history, physical examination and, in some probands, the results of HLA B 27 antigen determination, and x-ray examination. Overall, the prevalence of back pain in the cohort was 67%, with 63% and 76% in men and women, respectively. First complaints of back pain are most frequently reported by subjects in their 20s and 30s. The highest prevalence rate was registered in persons aged 50. The pain, as a symptom of a broad spectrum of pathological states, was most often localized in the lumbar and cervical segments of the spine -- 71% and 32%, respectively. In terms of the professions studied, the lowest prevalence was found in a group of manual workers employed at some worksites of the AVIA factory, with the highest frequency of back pain observed in an inconsistent group of diverse jobs, mostly requiring minimal training. In the Discussion section, the authors compare their results with those reported by some other studies published abroad.
[HLA antigens in Perthes disease].
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[Class I HLA factors (A, B, C) in patients with congenital hip dysplasia].
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[Genetic basis of autoimmunity].
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[The HLA-B27 antigen and pain syndromes of the spine in the Prague industrial population].
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[Wegener's granulomatosis with bilateral necrotizing scleritis].
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First class HLA factors (A,B,C,) in congenital hip joints dysplasia (CHJD).
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Cardiac involvement in progressive polyarthritis--an echocardiographic study.
Echocardiographic, electrocardiographic and roentgenologic examinations were performed in 50 patients with progressive polyarthritis without clinical signs of pericardial affection. At the same time, laboratory signs of the activity of the disease were evaluated. Using one-dimensional echocardiography, pericardial effusion was detected in 27 patients (54%). Neither valvular involvement nor specific changes in the myocardium were found. In the serum of patients with pericardial effusion the presence of the rheumatoid factor was statistically significantly more frequent than in patients without effusion. Patients with steroid therapy of the primary disease and a statistically significantly lower incidence of effusions than patients who were subjected to other forms of treatment. Echocardiography again proved to be the only sensitive non-invasive method capable of detecting small and medium-sized effusions.
[Immunology of systemic connective tissue diseases].
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[The significance of immunogenetics in the study of rheumatoid diseases].
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