Biomedical subjects
Publications and source records attributed to C E Muniz.
Although clinical manifestations of cocaine use are similar to the signs and symptoms of hyperthyroidism and research suggests that cocaine may affect the thyroid, no occurrences of cocaine-associated thyroid toxicity have been reported. The authors report a case of Graves' disease in a cocaine-dependent patient and propose that the patient's cocaine use may have precipitated thyroid toxicity.
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Lithium is effective in the treatment of bipolar disorder. Management of patients receiving prophylactic lithium therapy requires alertness to the development of neurologic, endocrine, cardiac and renal toxicity, as well as to dermatologic and gastrointestinal side effects. Lithium is involved in many drug interactions. Careful laboratory monitoring is essential, and treatment must be individualized.
Interactions between drugs can result in unintended changes in desired pharmacologic effects. Because psychotherapeutic drugs represent the most widely used class of pharmacologic agents, physicians must anticipate possible consequences of their interactions. An overview of drug interaction reports reveals that they can be usefully divided into those with either a pharmacokinetic or pharmacodynamic mechanism. We review the most important of these interactions and present methods to avoid or minimize their untoward effects.
A chronic schizophrenic patient with a neuroleptic-induced dystonic reaction and akathisia, both of which were unresponsive to benztropine and diphenhydramine, derived rapid therapeutic benefit from diazepam. This case report indicates that low-dose diazepam may be an extrapyramidal symptoms in some patients.
A method of dosing lithium based on a 24-hour serum lithium level obtained after a single 600-mg oral dose of lithium carbonate has been reported to provide a steady-state lithium concentration of 0.6--1.2 mEq/liter. Since this regimen is widely used in clinical practice, the authors designed a study to determine the practicality of the dosing guide. Of 13 patients who followed this dosing protocol, 4 (30.7%) failed to achieve the defined steady-state range. The authors discuss factors that may affect the reliability of the dosing guide.
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The successful use of thioridazine in the treatment of a propoxyphene dependent patient is presented. The drug controlled the craving and anxiety associated with the stepwise reduction of the propoxyphene.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.