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Practicality of a lithium dosing guide.

I F Naiman·C E Muniz·R B Stewart·R L Yost
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Abstract

A method of dosing lithium based on a 24-hour serum lithium level obtained after a single 600-mg oral dose of lithium carbonate has been reported to provide a steady-state lithium concentration of 0.6--1.2 mEq/liter. Since this regimen is widely used in clinical practice, the authors designed a study to determine the practicality of the dosing guide. Of 13 patients who followed this dosing protocol, 4 (30.7%) failed to achieve the defined steady-state range. The authors discuss factors that may affect the reliability of the dosing guide.

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Administration, OralAdultFemaleHumansLithiumMaleMiddle AgedJournal Article

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I F Naiman, C E Muniz, R B Stewart, R L Yost. 1981. Practicality of a lithium dosing guide.. https://doi.org/10.1176/ajp.138.10.1369

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