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Biomedical subjects

C Edling

Publications and source records attributed to C Edling.

At least 73 records · Page 4Linked to original sources
PubMed1989

An epidemiologic study of the relation between symptoms of fatigue, dental amalgam and other factors.

Fatigue has been described as a symptom of mercury toxicity. The aim of this pilot study was to investigate whether fatigue is related to the number of tooth surfaces of amalgam or to other factors. The study population was a group of 108 hospital workers who completed a self administered questionnaire including questions about fatigue in a study (1983) to determine the effects of exposure to glutaraldehyde. The 39 women who gave positive answers to one or two of the questions about fatigue were assigned cases. The referents were chosen with regard to sex, age and smoking habits among those who gave negative answers to both questions. Information about the number of surfaces of amalgam was received from dentists. Analysis showed that the cases and referents were not significantly different in terms of the mean number of surfaces of amalgam. There was a significant positive relation between the number of surfaces of amalgam and age as well as smoking habits. A significant positive relation was also found between symptoms of fatigue and psychosocial factors and the frequency of sick-leave in respiratory diseases. In conclusion other factors rather than the release of mercury from dental amalgam could explain the symptoms of fatigue.

Adult↗
PubMed1988

Occupational exposure to formaldehyde and histopathological changes in the nasal mucosa.

To study the cytotoxic effect of formaldehyde on the human nasal mucosa 75 men with occupational exposure to formaldehyde or to formaldehyde and wood dust, were examined, looking particularly at early signs of irritative effects and histopathological changes in the nasal mucosa. All men underwent a medical examination and a nasal biopsy specimen was examined by a pathologist and graded from 0-8 according to the morphological changes. A high frequency of nasal symptoms, mostly a running nose and crusting, was related to exposure to formaldehyde. Only three men had a normal mucosa; the remainder had loss of cilia and goblet cell hyperplasia (11%) and squamous metaplasia (78%); in six cases (8%) there was a mild dysplasia. The histological grading showed a significantly higher score when compared with unexposed contents (2.9 v 1.8). There was no dose response relation, no malignancies, and no difference in the histological score between those exposed to formaldehyde or to formaldehyde and wood dust.

Environmental Exposure↗
PubMed1987

Mortality among personnel exposed to diesel exhaust.

Some epidemiological studies have suggested a carcinogenic effect from diesel exhausts and also an increased risk of cardiovascular disease. This cohort study of bus garage employees was undertaken to elucidate further the health effects of diesel exhaust exposure with regard to mortality from cancer and cardiovascular disease. The cohort encompassed 694 men and was followed from 1951 through December 1983. The results showed no significant differences between observed and expected number of deaths in cancer or cardiovascular disease in total or with regard to different degrees of exposure or various requirements of exposure and induction-latency time. The so-called healthy worker effect was relatively weak for cardiovascular disease, but this phenomenon showed no pattern in relation to exposures. The relatively small size of the cohort does not allow for the exclusion of a slightly increased incidence of cancer of certain sites, however.

Cardiovascular Diseases↗
PubMed1987

Mortality and cancer incidence among workers in an abrasive manufacturing industry.

Earlier epidemiological studies have shown that exposure to aluminium oxide and silicon carbide might carry with it an increased risk of lymphomas, stomach cancer, and non-malignant respiratory disease. To elucidate further this possible hazard, the cancer morbidity and the total mortality pattern was studied among 521 men manufacturing abrasive materials who had been exposed to aluminium oxide, silicon carbide, and formaldehyde. Total dust levels were in the range of 0.1-1.0 mg/m3. The cohort was followed up from 1958 until December 1983. No significant increase was found in total mortality, cancer mortality, or incidence of non-malignant respiratory diseases.

Aluminum Oxide↗
PubMed1987

Audiological and vestibulo-oculomotor findings in workers exposed to solvents and jet fuel.

Three groups of subjects with long-term (5-41 years) occupational exposure to industrial solvents have been evaluated with extensive audiological and vestibular test batteries. Group A comprised 16 subjects with a confirmed diagnosis of psycho-organic syndrome (POS), while group B consisted of 7 subjects with suspected POS. Both groups had been exposed to mixtures of aliphatic and aromatic solvents. Eight subjects with long-term exposure to jet fuel constituted group C. In the audiological test battery, discrimination of interrupted speech and evoked cortical potentials in response to frequency glides were the tests that yielded significantly abnormal results. In the vestibular test battery, considerable pathology was seen in electronystagmography, and in addition, visual suppression test and saccade test indicated CNS disturbance. In general, when a test yielded pathological results, the incidence of pathology was highest in group A and lowest in group C.

Adult↗
PubMed1987

Occupational formaldehyde exposure and the nasal mucosa.

This study was undertaken to evaluate the possible cytotoxic effect of formaldehyde on the nasal mucosa in man. 38 men with an average age of 38 years and average exposure time of 10.5 years were studied. They were exposed to formaldehyde when processing laminae. All men passed a medical examination and a nasal biopsy. The histological findings were scored, 0-8, according to a system proposed by Torjussen. The findings were compared with a non-exposed reference group of 25 men (mean age 35 years). 35% of the exposed were smokers compared to 48% of the nonexposed. The average histological score was 2.8 for the exposed versus 1.8 for the non-exposed (p less than 0.05, Wilcoxon). The more common findings in the exposed were loss of cilia, goblet cell hyperplasia and squamous metaplasia. In four cases (11%) there was a mild dysplasia. Smoking had a slight modifying effect on the histological picture. The results indicate that the suspected precancerous findings in animal studies after exposure to formaldehyde might be present in workers exposed to formaldehyde at relatively low levels.

Adult↗
PubMed1986

Lung function in workers using cadmium containing solders.

The lung function of 57 male workers previously exposed to cadmium in connection with the use of cadmium containing solders was examined by spirometry (FVC, FEV1, FEV%, and MMF) and single breath nitrogen washout (CV, CV%, and phase III). A reference group (n = 31) from a nearby industry was examined at the same time. Despite the fact that the exposure in previous years had been relatively high, in the order of 0.05-0.5 mg Cd/m3, and that 24 (42%) of the workers had cadmium induced renal damage in the form of beta 2-microglobulinuria there was no evidence of pulmonary damage. There were no significant differences in lung function data from the exposed and reference group and there was no dose-response relation within the exposed group. It thus appears that signs of kidney toxicity in the form of low molecular weight proteinuria precede those that may be identified in the lung with commonly used lung function tests.

Cadmium↗
PubMed1986

Cancer mortality among leather tanners.

Workers were studied at a tannery that operated from 1873 to 1960, once one of the biggest in Scandinavia. The results show a slight numerical increase of deaths from cancer of the stomach and a significant, threefold excess mortality from cancer of the pancreas. Even in view of critical questions about validity it seems likely that this excess might be related to exposure to chemicals in tannery work.

Aged↗
PubMed1985

beta 2-Microglobulinuria among workers previously exposed to cadmium: follow-up and dose-response analyses.

Sixty workers (58 males, 2 females) who had previously been exposed to cadmium in connection with the use of cadmium-containing solders were examined. Exposure times ranged from 4 to 24 years. For each worker a cumulative cadmium dose estimate was calculated. This ranged from 0.35 to 9.9 mg/m3 X year. The prevalence of slight (U-beta 2 greater than 0.034 mg/mmole creatinine) and more pronounced (U-beta 2 greater than 0.1 mg/mmole creatinine) beta 2-microglobulinuria in the whole group was 40% and 23%, respectively. The prevalence of beta 2-microglobulinuria was strongly related to the cumulative dose estimate and to urinary cadmium level. Among workers with a cumulative dose estimate below 1 mg/m3 X yr there were only a few cases with slight tubular proteinuria, whereas for workers who had a cumulative dose estimate exceeding 3 mg/m3 X yr the prevalence of slight and pronounced beta 2-microglobulinuria was 77% and 54%, respectively. There was no significant relationship between the concentration of beta 2-microglobulin in serum and urine. This indicates that the beta 2-microglobulinuria is due to tubular damage and is not secondary to an increased endogenous production. Repeated examinations of 19 workers between 1976 and 1983 revealed that in almost all cases the beta 2-microglobulinuria was irreversible.

Adult↗
PubMed1985

Assessment of renal function in workers previously exposed to cadmium.

Cadmium induced renal effects were examined in 60 workers (58 men, 2 women) previously exposed to cadmium. Tubular damage in the form of beta 2-microglobulinuria was found in 40%, and urinary albumin and orosomucoid increased significantly with increasing urinary cadmium and increasing relative clearance of beta 2-microglobulin. It is suggested that increased albumin excretion is secondary to the tubular damage. In no case was typical glomerular proteinuria found that could be related to cadmium. Histories of renal stones were more common among the workers with high urinary cadmium concentrations. The glomerular filtration rate was measured in 17 of the workers who had pronounced tubular dysfunction. The average glomerular filtration rate for these men was less than the age adjusted predicted value (mean = 84%). Furthermore, there was a significant (p less than 0.05) correlation (r = -0.47) between tubular reabsorption loss and a decreased glomerular filtration rate.

Adult↗
PubMed1985

No acute behavioural effects of exposure to styrene: a safe level of exposure?

To determine whether exposure to low levels of styrene (below 110 mg/m3) causes acute behavioural effects and symptoms that may be related to concentrations of styrene in air or urinary mandelic acid or both, 12 men occupationally exposed to styrene were studied and compared with a reference group of 10 unexposed men. Simple reaction time was measured before and after work and information about symptoms was obtained by questionnaire. Active and passive sampling of airborne styrene was carried out and urinary mandelic acid concentrations were measured. Although the size of the study groups is small, the results indicate that exposure to styrene below 110 mg/m3 does not cause any acute adverse effects on the central nervous system.

Adult↗
PubMed1984

Clinical studies of psychoorganic syndromes among workers with exposure to solvents.

Exposure to organic solvents is common in industry. In Sweden, patients being evaluated for suspected solvent-related diseases now constitute the largest group of patients seen at many clinics of occupational medicine, largely replacing classical occupational disorders. The findings in 128 consecutive patients with solvent exposure have been reviewed for the period 1978-1981. The duration of exposure was 9 years or more for those with a diagnosis of psychoorganic syndrome (POS). "Incipient" POS was seen after a minimum exposure of 3 years duration. Patients with POS also had an increased frequency of polyneuropathy in comparison to those without any signs of POS. It was not possible to link these abnormalities with particular solvent exposure. Clinical chemistry tests were normal except for liver function tests in a few patients.

Adult↗
PubMed1984

Risk factors of coronary heart disease among personnel in a bus company.

A cohort of all the men employed in a bus company was undertaken to elucidate possible adverse health effects of diesel exhaust exposure. The results showed that the most heavily exposed group (bus garage workers) had a fourfold increase in risk of dying from cardiovascular disease, even after correction for smoking, and allowing for at least 10 years of exposure and 15 years or more of induction-latency time. The findings are in accordance with the hypothesis of a possible connection between exposure to carbon monoxide and cardiovascular disease.

Carbon Monoxide Poisoning↗