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Biomedical subjects

C F Beckmann

Publications and source records attributed to C F Beckmann.

At least 37 records · Page 2Linked to original sources

Segmental pancreatic autotransplantation for chronic pancreatitis.

Three patients who underwent 95 percent removal of the pancreas for chronic pancreatitis with autotransplantation of the body and tail of the gland to the femoral area are described. The follow-up periods are 18, 6, and 2 months. Pain lessened in all patients and none required exogenous insulin. Patency of the graft was documented in all patients by angiography, technetium scan, and Doppler studies. Percutaneous selective venous assays of both external iliac veins showed a high insulin concentration in the transplanted side, both early and late in the postoperative period. In one patient the operative insulin levels obtained at the completion of autotransplantation proved to be highest in the external iliac vein on the transplanted side, lowest in the iliac vein on the nontransplanted side, and intermediate in the portal vein. Subsequent biopsies of the autografts showed fibrosis of the gland and atrophy of the acinar tissue with preservation of islet tissue. This technique appears to offer a means of preserving endocrine function in selected patients who require extensive resection for chronic pancreatitis.

Adult↗

Transcatheter embolization of the liver for control of massive hemobilia in a patient with adenocarcinoma of the gallbladder invading the intrahepatic biliary system.

Successful control of massive hemobilia by combined peripheral and proximal transcatheter embolization of the liver is described. Our patient had adenocarcinoma of the gallbladder with extension to the liver and invasion of intrahepatic and extrahepatic bile ducts. This caused hemobilia which became uncontrollable after percutaneous exchange of biliary drainage catheter that had been placed previously for relief of obstructive jaundice.

Adenocarcinoma↗

Incomplete myocardial reperfusion despite a patent coronary bypass: a generally unrecognized shortcoming of the surgical approach to coronary artery disease.

When assessing a coronary artery bypass graft, the patency rate is virtually the sole criterion of success. However, this fails to identify grafts which are patent by incompletely reperfuse the diseased vessel. Angiograms of 82 patients with 172 bypassed coronary arteries confirmed patency in 126 (73%); however, in 30 reperfusion was incomplete though the graft was patent, making the rate of complete reperfusion only 56% (96/172). Causes included localized narrowings in the region of the anastomosis [9], significant narrowing along the graft [6], pre-existing additional stenoses in the native vessel, remote from the anastomosis and the lesion [7], stenoses not present preoperatively but seen postoperatively in the native vessel, remote from the anastomosis and original lesion [6], and separate obstructions of unbypassed branches [2]. While incomplete reperfusion is often unavoidable and is certainly preferable to total occlusion, evaluation based purely on patency rates is misleading, since it overlooks the fact that a significant proportion of patent grafts will not totally reperfuse the diseased vessel.

Adult↗

Comparison and significance of bypass patency rates in noncritical versus critical coronary obstruction.

Preoperative and postoperative angiograms were compared in 81 patients who had undergone coronary artery bypass surgery. In these patients, 135 bypassed vessels had had critical stenoses or total occlusion; 99 of these bypasses (73.3%) were patent. Of 36 bypassed vessels that had had noncritical stenoses, 26 (72.2%) were patent. This difference was not significant. Thus, competitive inflow does not lead to excessive graft failure in noncritically diseased vessels, and they can be bypassed with the same expectation of success as critically obstructed vessels. The risk and the advantages of bypassing mild lesions at the same time that severe obstructions are surgically treated are discussed.

Adult↗

Idiopathic renal vein varices: incidence and significance.

To determine the incidence of renal vein varices, an analysis of 132 consecutive renal venograms was performed. Varices were found in 8 patients (6%), always on the left side. Four were solitary, and four represented a dilated venous network adjacent to the renal pelvis and upper ureter. Only a single patient had hematuria attributed to renal vein varices. It is concluded that varices in association with hematuria cannot be assumed to be causative; they may equally well be incidental findings.

Adolescent↗

Balloon occlusion superior mesenteric arteriography for improved venous opacification: a clinical trial.

Balloon occlusion superior mesenteric arteriography and nonocclusion superior mesenteric arteriography were compared prospectively and retrospectively for adequacy of mesenteric and portal venous visualization. Prospective, occlusion studies in 20 patients were uniformly judged of excellent visual quality, while retrospectively, only 30% of nonocclusion studies from 20 other patients were considered optimal. In 10 of the patients who had balloon occlusion superior mesenteric arteriography, the procedure was preceded by a control nonocclusion superior mesenteric arteriography study. In only two (20%) patients was the nonocclusion study rated of excellent visual quality. Each study was assessed a rating of 0-3, according to how well the mesenteric and portal venous system visualized. Prospectively, all 20 balloon occlusion superior mesenteric arteriography studies were given the highest obtainable rating (3). Retrospectively, only six (30%) 20 nonocclusion superior mesenteric arteriography studies received a rating of 3; hence, 14 (70%) of the nonocclusion studies were rated less than excellent in visual quality when looked at retrospectively. No complications occurred with balloon occlusion superior mesenteric arteriography, and the occlusion procedure consistently gave excellent visualization of the mesenteric and portal venous anatomy.

Angiography↗

The effect of sequential arterial stenoses on flow and pressure.

The additive effect of two sequential stenoses on arterial flow and pressure was studied in five dogs, using an extracorporeal aorto-femoral shunt. It was determined that the concept of flow being governed by the more severe stenosis is imprecise. This is true only of one critical and one subcritical lesion: two critical stenoses have an additive effect. Otherwise subcritical stenoses can become critical in the presence of hyperemia. When evaluating patients with vascular insufficiency due to arterial narrowing, all stenoses should be carefully assessed and attention directed to their cumulative effect.

Animals↗

The effect of coronary artery bypass on collateral circulation.

The effect of coronary bypass upon collateral circulation (CC) was studied in 69 bypassed coronary arteries in which CC was seen on either the preoperative or postoperative angiogram or both. CC proved to be a highly reliable indicator of bypass effectiveness. Persistence or new development of CC on postoperative angiograms invariably indicated complete bypass obstruction or inadequate revascularization. Disappearance of preexisting CC on postoperative angiograms almost always indicated bypass patency. Occlusion of a bypass does not appear to jeopardize preexisting CC or prevent new CC from developing in most cases.

Adult↗

Frequency and clinical significance of failure to visualize the conus artery during coronary arteriography.

In patients with occlusion of the left anterior descending coronary artery (LAD) or right coronary artery (RCA), the conus artery, which arises at or near the origin of the RCA, often serves as a principal source of collateral circulation. Coronary arteriograms in 508 adult patients revealed that in 80.5% the conus artery was well visualized on the RCA angiogram, but that in 19.5% it was not adequately visualized due to injection of contrast distal to its origin. In the latter patients, the presence of conus-LAD or conus-RCA collaterals might therefore go undetected. Because the degree of distal filling via collateral circulation affects medical and surgical decisions, it is important to attempt to visualize the conus artery adequately whenever the LAD or RCA is obstructed.

Angiography↗

Renal venography: anatomy, technique, applications, analysis of 132 venograms, and a review of the literature.

Selective renal venography is a simple but important diagnostic procedure which has few complications. A thorough knowledge of renal venous anatomy is essential for its proper performance and clinical application. This is particularly true because renal venous variations are frequent and may interfere with the successful appraoch to retroperitoneal surgery. The method is widely accepted for the evaluation of the renal venous bed in patients with suspected renal vein thrombosis or hematuria of unknown etiology. It depicts the extent of renal venous involvement in renal carcinoma and clarifies the diagnosis in some patients with avascular tumors, renal pelvic carcinoma, and retroperitoneal tumors. It may also be useful in defining the morphologic abnormality when the kidney fails to visualize on urography, in delineating the extent and nature of renal parenchymal disease, and in enhancing the precision of renal vein renin collection.

Adolescent↗

Experimental determination of flow patterns of gelfoam emboli: safety implications.

A major potential hazard of therapeutic occlusion of arteries by selectively injected Gelfoam pledgets is inadvertent reflux of nonopaque emboli into the aorta with resultant occlusion of other vessels. A simple method of injecting Gelfoam emboli through the standard nonoccluding arterial catheters customarily used for diagnostic arteriography was experimentally tested. The method incorporated certain safety features such as introduction of one embolus at a time using tuberculin syringes, low pressure injection technique, and frequent test injections of contrast to ascertain vessel patency. The results indicate that Gelfoam emboli can be safely and reliably employed using this technique, provided the catheter tip is properly positioned and emboli are only introduced as long as contrast test injections demonstrate rapid antegrade flow and continued patency of the artery. Once stasis or occlusion of most major branches are detected, blood flow in the catheterized artery has effectively ceased and further embolization is risky.

Animals↗

Cinefluoroscopy in evaluating left ventricular contractility and aneurysms.

Cardiac cinefluoroscopy was performed immediately prior to biplane left ventriculography in 113 patients and the findings of two independent observers compared to the angiographically documented state of the left ventricle. The observers' interpretations were correct in 44% and 46% of studies, respectively; there were 41% and 24% false negatives and 24% and 29% false positives. The observers agreed in only 59% of cases. The results show that cinefluoroscopy for evaluation of left ventricular contractility is grossly inaccurate and should not be performed.

Cineradiography↗

Circumaortic venous ring: incidence and significance.

A left circumaortic renal vein was found in 11% of 74 left renal venograms, an incidence similar to that at autopsy. Cavography proved to be an unsatisfactory method of demonstrating the renal veins. Prior knowledge of a venous ring is important when blood samples from the adrenal or renal veins are to be collected. When caval interruption is planned, a circumaortic venous ring may provide a fully developed collateral pathway immediately after surgery if the procedure is planned without awareness of its presence.

Abnormalities, Multiple↗

Suprarenal aortic occlusion.

Proximal propagation of an occlusive distal aortic thrombus to the suprarenal level is rare, probably resulting from diminished renal blood flow, and is invariably accompanied by renal failure. Three similar cases of total suprarenal aortic occlusion with renal failure are presented. In each, one kidney was significantly smaller than the other, probably caused by long-standing disease. The combination of bilaterally absent or markedly decreased femoral pulses with diminished renal function or a unilateral small kidney should therefore be considered dangerous. To prevent proximal propagation of thrombosis and death from renal failure, such patients should undergo arteriography and surgical repair promptly even though their clinical symptoms might be relatively mild and stable.

Acute Kidney Injury↗

Renal vein valves: incidence and significance.

Although autopsy studies have demonstrated valves in 28-70% of right and 4-36% of left renal veins, they have rarely been detected or described during life. In an analysis of 98 renal venograms, valves were found in 16% of patients on the right side and in 15% on the left, without predilection for any particular location. Angiographically, they appeared as thin, web-like structures which may block passage of the catheter or of contrast material, and hence cause poor venographic filling. Rarely, valves produce total obstruction to the retrograde flow of contrast material.

Epinephrine↗

Angiography of nonfunctioning pheochromocytomas of the adrenal gland.

Two patients with clinically nonfunctioning pheochromocytomas of the adrenal gland were studied angiographically. The radiological characteristics were indistinguishable from those of functioning pheochromocytomas. In patients with hypervascular adrenal masses, the diagnosis of pheochromocytoma should be considered even in the absence of customary signs and symptoms.

Adrenal Gland Neoplasms↗

Cardiomegaly as a cause of nonuniform pulmonary artery perfusion.

In patients with cardiomegaly, a common cause of nonuniform pulmonary artery perfusion on pulmonary arteriograms is compression of the left lower lobe arteries by the enlarged heart, an effect which is accentuated by gravity in the supine position. This may impede flow in such a manner as to erroneously suggest the presence of pulmonary emboli. Subselective left lower lobe arteriography with the patient in the right posterior oblique position will allow better anatomic definition of the vessels in this region and result in fewer equivocal or false positive studies.

Adult↗