Physicians with opioid dependence.
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Biomedical subjects
Publications and source records attributed to C F Ward.
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The coagulopathies associated with amyloidosis have not been widely appreciated. We encountered a patient with amyloidosis and mildly abnormal coagulation studies who presented for an emergency laparotomy for acute bowel obstruction. Upon gentle manipulation of the bowel, an unexpected bleeding diathesis was manifested by the formation of several large haematomas resulting in a large amount of blood loss (approximately 800 ml). Numerous defects of platelet function and coagulation have been associated with amyloidosis, including abnormal platelet aggregation, increased vascular fragility, factor IX and X deficiencies, decreased levels of alpha-2-plasmin inhibitor, and increased levels of plasminogen. Intraoperative therapy for our patient included the rapid administration of four units of fresh frozen plasma and ten units of platelet concentrate. A review of the pathology and therapeutic modalities for this potentially life-threatening complication is presented.
Rapid fluid infusion is generally augmented by compression devices (pumps) that take advantage of compressibility of modern plastic fluid containers. The most commonly used pumps are not the most effective pressure sources for driving pressure. This paper describes the experience at a Level I trauma hospital with a relatively new device that serves as a more efficient source of pressure for rapid fluid administration. This device, commercially manufactured but locally modified, increases capability with minimal expense and additional training.
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Monitoring in pediatric anesthesia practice encompasses essentially the same spectrum of techniques and measurements as monitoring of adult patients, except that techniques are modified positively by the generally better health of children and negatively by conflicting anecdotes concerning how rapidly negative effects can occur in anesthetized children. As a consequence, progress has followed two general tracks: (1) cautious expansion of invasive techniques, such as arterial and central venous blood pressure monitoring and (2) more vigorous expansion of noninvasive techniques. Progress in the use of invasive techniques is affected by technical difficulties and fear of causing patient harm, while advances in noninvasive monitoring have been fueled by recognition of the inherent value of reliable and constant measurement of essential variables, such as peripheral oxygenation and end-tidal carbon dioxide tension. This article reviews both tracks, updating knowledge of invasive techniques and providing a discussion of less glamorous but more broadly useful noninvasive methods, such as automated blood pressure monitoring and pulse oximetry.
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Patients who have received thorium dioxide (Thorotrast) are at risk for hepatic and other malignancies. Because of the need to identify and carefully follow up these patients, we have presented three cases with the characteristic radiologic findings on plain films so that physicians unfamiliar with this appearance will now be aware of it.
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