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Biomedical subjects

C Fox

Publications and source records attributed to C Fox.

At least 127 records · Page 7Linked to original sources
PubMed1978

Pupillary signs in diabetic autonomic neuropathy.

Pupillary function was investigated in 36 insulin-dependent diabetics and 36 controls matched for age and sex. About half of the diabetics had evidence of peripheral somatic or autonomic neuropathy, or both. The diabetic patients had abnormally small pupil diameters in the dark and less fluctuation in pupil size (hippus) during continuous illumination than the controls. They also had reduced reflex responses to light flashes of an intensity adjusted for individual retinal sensitivities. The pupillary findings were compared with results of five tests of cardiovascular function and five tests of peripheral sensory and motor nerve function. Almost all the patients with autonomic neuropathy had pupillary signs, which we therefore conclude are a common manifestation of diabetic autonomic neuropathy.

Adolescent↗
PubMed1978

Lecithin--cholesterol acyltransferase and the lipoprotein abnormalities of obstructive jaundice.

1. We have studied the plasma lipoprotein abnormalities in obstructive jaundice to test the hypothesis that the abnormalities would correlate with plasma lecithin--cholesterol acyltransferase activity. 2. Very-low-density lipoproteins (VLDL) were normal in composition and had a normal pre-beta electrophoretic mobility when lecithin--cholesterol acyltransferase activity was high. When it was low VLDL had abnormal composition and ran in the beta position. 3. With high lecithin--cholesterol acyltransferase activity, low-density lipoprotein (LDL) was normal and cholestatic LDL (LP-X) was not found. With low lecithin--cholesterol acyltransferase activity up to three LDL fractions were found: (i) large triglyceride-rich particles, (ii) LP-X and (iii) a triglyceride-rich cholesteryl ester-poor particle of normal dimensions. 4. High-density lipoprotein (HDL) concentrations correlated with lecithin--cholesterol acyltransferase activity and HDL were normal in composition and electron-microscopic appearance when the activity was high. When lecithin--cholesterol acyltransferase activity was low HDL was abnormal in composition and 'stacked discs' were seen on electron microscopy as well as normal spherical particles. 5. These results suggest that low lecithin-cholesterol acyltransferase activity may cause at least some of the lipoprotein changes of obstructive jaundice.

Adult↗
PubMed1977

Streptozotocin-induced renal tumours in rats.

Forty-six separate renal tumours developed in 36/80 Wistar male rats given a single i.v. dose of streptozotocin (25 mg/kg body wt) to induce diabetes mellitus. Fourteen of the tumours were epithelial in type, 8 were wholly mesenchymal and 24 were largely mesenchymal but also contained epithelial elements. The purely epithelial tumours correspond to the renal adenomas and adenocarcinomas seen in man. The mesenchymal tumours were composed either of undifferentiated spindle cells or of a mixutre of poorly differentiated mesenchyme and epithelial glands. Microscopically, the mixed tumours resembled the nephroblastomas seen in man; both elements appeared to be malignant, but in the absence of metastases this remains unproven. The management of the diabetic state did not influence the incidence of tumours, but insulin appeared to enhance tumour growth.

Animals↗
PubMed1976

Towards a family approach in a psychiatric day hospital.

In a day hosptial all staff members must be able to make rapid decisions, even when they cannot refer to their seniors. It is difficult to develop this capability in a teaching day hospital where the staff and student groups are constantly changing. It has, however, been facilitated by regular staff discussions with a visiting psychotherapist. In these staff groups, the study of role attributions and dynamics characteristic of families has diminished the interference caused by 'family' type dynamics in daily professional interaction. The paper describes the effect of such discussion in stimulating the adoption of a treatment approach which takes the family situation into account. This family approach is distinguished from family therapy, and its advantages are discussed.

Attitude of Health Personnel↗
PubMed1976

Late results of valvoplasty for mitral regurgitation due to rupture of chordae of the posterior (mural) cusp.

Nine patients with rupture of chordae tendinea of the posterior cusp of the mitral valve are presented. All have been treated by plication of the posterior cusp and atrial wall. The presenting postoperative features have been described: 89 per cent are markedly improved; two patients have normal heart sounds with no murmurs; 6 patients have only a Grade 1 pansystolic apical murmur. The advantages of this procedure compared with mitral valve replacement for the same condition have been presented.

Aged↗
PubMedDate not supplied

Rural physicians, rural networks, and free market health care in the 1990s.

The changes brought about by managed care in America's urban communities will have profound effects on rural physicians and hospitals. The rural health care market characterized by small, independent group practices working with community hospitals is being offered affiliations with large, often urban-based health care organizations. Health care is evolving into a free market system characterized by large networks of organizations capable of serving whole regions. Rural provider-initiated networks can assure local representation when participating in the new market and improve the rural health infrastructure. Although an extensive review of the literature from 1970 to 1996 reveals little definitive research about networks, many rural hospitals have embraced networking as one strategy to unify health care systems with minimal capitalization. These networks, now licensed in Minnesota and New York, offer rural physicians the opportunity to team up with their community hospital and enhance local health care accessibility.

Capitation Fee↗
PubMedDate not supplied

The Pegasus Overture alternating-pressure mattress overlay.

Pressure sores affect approximately 10% of the adult population and occur in various hospitals and community settings (Department of Health, 1992). It is therefore essential to adopt a logical approach when selecting the optimum piece of equipment for patients at risk of pressure sore development. Alternating-pressure mattresses have been used for many years in both hospitals and community environments to prevent and treat pressure sores. In September 1995, Pegasus Airwave Limited launched a new alternating-pressure mattress overlay, the Overture. It is designed for use with patients who have mobility problems and are at low to medium risk of developing pressure sores or have superficial tissue damage. This article describes the features of the Overture and its suitability for use in different care settings.

Adult↗
PubMedDate not supplied

The Softform pressure-reducing mattress for high-risk patients.

This article highlights the fundamental difference between pressure-relief and pressure-reduction. The limitations of the conventional hospital mattress will be discussed in terms of lack of support properties and life expectancy. The need for a coordinated mattress replacement programme will be outlined and the advantages of the Softform pressure-reducing mattress will be described in detail.

Beds↗
PubMedDate not supplied

The Pentaflex pressure-reducing mattress replacement.

Support surfaces play a crucial role in pressure sore prevention. This article outlines the use of polyurethane foam as a versatile and effective support surface. It briefly describes a number of tests which are used to determine foam quality and summarizes the characteristics and clinical evidence supporting the use of the Pentaflex pressure-reducing foam mattress.

Beds↗