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Biomedical subjects

C Frey

Publications and source records attributed to C Frey.

At least 55 records · Page 3Linked to original sources
PubMed1993

Multicenter evaluation of a broth macrodilution antifungal susceptibility test for yeasts.

Thirteen laboratories collaborated to optimize interlaboratory agreement of results of a broth macrodilution procedure for testing three classes of antifungal drugs against pathogenic yeasts. The activities of amphotericin B, flucytosine, and ketoconazole were tested against 100 coded isolates of Candida albicans, Candida tropicalis, Candida parapsilosis, Candida lusitaniae, Torulopsis (Candida) glabrata, and Cryptococcus neoformans. Two starting yeast inoculum sizes (5 x 10(4) and 2.5 x 10(3) cells per ml) were compared, and readings were taken after 24 and 48 h of incubation. All other test conditions were standardized. The resultant turbidities in all tubes were estimated visually on a scale from 0 to 4+ turbidity, and MIC-0, MIC-1, and MIC-2 were defined as the lowest drug concentrations that reduced growth to 0, 1+, or 2+ turbidity, respectively. For flucytosine, agreement among laboratories varied between 57 and 87% for different inocula, times of incubation, and end point criteria. Agreement was maximized (85%) when the lower inoculum was incubated for 2 days and the MICs were defined as 1+ turbidity or less. For amphotericin B, variations in test conditions produced much smaller differences in interlaboratory agreement. For ketoconazole, interlaboratory agreement was poorer by all end point criteria. However, MIC-2 endpoints distinguished T. glabrata as resistant compared with the other species. Overall, the studies indicated that readings from the lower inoculum obtained on the second day of reading result in the greatest interlaboratory agreement. In combination with data from previous multicenter studies (National Committee for Clinical Laboratory Standards, Antifungal Susceptibility Testing: Committee Report, Vol. 5, No. 17, 1988; M. A. Pfaller, L. Burmeister, M. S. Bartlett, and M. G. Rinaldi, J. Clin. Microbiol. 26:1437-1441, 1988; M. A. Pfaller, M. G. Rinaldi, J. N. Galgiani, M. S. Bartlett, B.A. Body, A. Espinel-Ingroff, R.A. Fromtling, G.S. Hall, C.E. Hughes, F. C. Odds, and A. M. SUgar, J. Clin. Microbiol. 34:1648-1654, 1990), these findings will be used by the National Committee for Clinical Laboratory Standards to develop a standardized method for in vitro antifungal susceptibility testing for yeasts.

Antifungal Agents↗
PubMed1993

American Orthopaedic Foot and Ankle Society women's shoe survey.

Shoes have been implicated as being responsible for the majority of foot deformities and problems that physicians encounter in women. A total of 356 women were studied in this investigation to evaluate trends in women's shoe wear and their effect on the development of foot deformities and pain. The majority of women in this study wore shoes that were too small for their feet, had foot pain and deformity, and had increased shoe size since the age of 20. Few women had their feet measured in over 5 years. The women without foot pain or deformities also wore shoes that were smaller than their feet but to a lesser degree.

Adult↗
PubMed1993

Tarsal tunnel syndrome secondary to cosmetic silicone injections.

Silicone has been implicated as a cause of inflammatory disorders in the body including synovitis and lymphangitis. Silicone particulate matter has been shown to cause a fairly severe chronic foreign body reaction with the use of silicone prosthesis in the foot. This reaction was often overlooked for years because of the limited number of subjective complaints. There are case reports of granulomatous inguinal lymphadenopathy following first metatarsophalangeal joint silicone arthroplasty. Similar findings have been noted in the axilla with hand implants and breast implants. Of greater significance are two reports of malignant lymphoma found with silicate lymphadenopathy.

Adult↗
PubMed1992

[Intellectual and neurological development of 9-15-year-olds who were born as at-risk neonates].

This retrospective study deals with 296 children born between 1, Jan. 1974 and 31, Dec. 1980, who had been hospitalized as newborns at the Department of Pediatrics of the University of Berne and who had been considered at risk for abnormal psychomotor development because of well defined perinatal risk factors. Their psychomotor development had first been evaluated in the first months and years of life at the Cerebral Palsy Centre at Berne. In 1989, when the children were 9-15 years old, their neuro-intellectual development was investigated through a questionnaire sent to the families dealing with the subsequent psychosocial and scholastic course. In the CP-Centre, at a median age of 10 and mean age of 26.4 months, 247 (83.5%) of the children had been discharged with the finding of normal psychomotor development, 25 (8.4%) had been considered to show questionable findings and 24 (8.1%) to show obvious abnormal psychomotor development. On the basis of the answers to the questionnaire (median age 11 8/12, mean age 11 10/12 years; 62% return rate), 39.3% of the children had had no further problem, and 57.4% had used special support such as speech therapy or educational consulting and/or had had school problems. 3.3% showed distinct learning disabilities. More than 90% were attending a normal public school. This corresponds to the attendance in the general population. However, fewer children were in higher schools. To investigate whether the judgement in the first months and years (CP-Centre) of life corresponded to the further development (questionnaire), a subpopulation was specially evaluated in addition.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1992

[Psychosocial development in cystic fibrosis].

This brief review outlines of the current research on psychosocial stress and coping of children and adolescents with cystic fibrosis (CF) and of their families. Next to medical facts aspects of normal development as well as specific problems in individual periods of life are presented proceeding from an individual to a familial view. Requirements for a comprehensive bio-psychosocial care are raised. Flexible models of care have to take into account the circular process of individual and familial coping with chronic disease. Helpful support of CF-Patients and their families requires interdisciplinary cooperation in the CF-team.

Adaptation, Psychological↗
PubMed1992

[Psychosocial aspects of cystic fibrosis].

Psychosocial stress and coping in families with cystic fibrosis (CF) are described. The illness does not lead to specific psychopathological disturbances, but with additional intra- or extra-familial stress, patients and family members are more vulnerable to psychoreactive disorders. Interdisciplinary and family oriented bio-psycho-social care is required. The role of the child psychiatrist is discussed.

Adaptation, Psychological↗
PubMed1992

The retrocalcaneal bursa: anatomy and bursography.

The retrocalcaneal bursae, located between the posterior angle of the os calcis and the Achilles tendon, may become inflamed and hypertrophied. There are few objective tests available for the diagnosis of pain syndromes involving the hindfoot and it is often difficult to differentiate Achilles tendinitis and retrocalcaneal bursitis. Retrocalcaneal bursograms can provide further insight into chronic changes in the bursae associated with traumatic and inflammatory conditions. This report describes the anatomy of the retrocalcaneal bursa, the technique of its opacification, and the application of this technique to the diagnosis and treatment of painful hindfoot syndromes. In addition, the anatomy of the retrocalcaneal bursa was investigated further using latex casting techniques. Twelve cadaver limbs were injected with radiopaque latex casting material or renografin into the retrocalcaneal bursae. AP, lateral, and oblique radiographs were then obtained on the specimens. The size, capacity, and configuration of the postmortem bursae were measured and recorded. Subsequently, the cadaver limbs injected with the latex material were cooled and dissection was made of the retrocalcaneal bursae. The latex bursal molds were measured, graphically recorded, and photographed. Fifteen patients with signs and symptoms of retrocalcaneal bursitis and eight asymptomatic patients were selected for this study and injected with radiopaque material into the bursae. Anteroposterior, lateral, and oblique radiographs were then obtained. The size, capacity, and configuration of the retrocalcaneal bursae were measured and recorded. The anatomic characteristics noted from the latex bursal molds correlated well with the findings on bursography. Bursographic findings in patients with retrocalcaneal bursitis can provide insight into the diagnosis and clinical management of this disorder.

Achilles Tendon↗
PubMed1991

Plasma growth hormone (GH)-releasing hormone levels in patients with lung carcinoma.

OBJECTIVE: The aim was to investigate the serum levels of growth hormone releasing hormone and GH in patients with lung carcinoma. DESIGN After an overnight fast a plasma sample was collected for determination of growth hormone releasing hormone and GH. PATIENTS: The investigation was performed in 28 patients with non small cell lung carcinoma, in 44 patients with small cell lung carcinoma, and 10 patients with non malignant lung disease. A group of 37 normal subjects served as control. MEASUREMENTS: Growth hormone releasing hormone and GH were determined by radioimmunoassay. RESULTS: Patients with small cell lung carcinoma showed higher plasma growth hormone releasing hormone levels (49 +/- 9.4 ng/l) than control subjects (16.3 +/- 2.1 ng/l; P less than 0.05), patients with non small cell lung carcinoma (23.9 +/- 8.8 ng/l; P less than 0.05), and patients with non malignant lung disease (12.7 +/- 5.5; P less than 0.05). Basal GH level was lower than 5 micrograms/l in all patients except five patients with small cell lung carcinoma and one patient with non small cell lung carcinoma. CONCLUSIONS: The higher plasma growth hormone releasing hormone levels in patients with small cell lung carcinoma compared to normal controls and patients with non small cell lung carcinoma and patients with non malignant lung disease, confirm the frequent neuroendocrine activity of this particular tumour.

Adult↗
PubMed1991

The Akin procedure: an analysis of results.

This paper reports the initial and long-term results of 45 Akin procedures done at the Hospital for Joint Diseases/Orthopaedic Institute from 1966 to 1985. Indications for 36 of the 45 operated feet were for an essentially asymptomatic great toe valgus deformity which caused symptoms to develop in the second toe and in 9 of 45 feet for residual hallux valgus after previous hallux valgus surgery. Excellent and good results were reported in 89% of the patients. The most common technical problem reported in 22% of the patients was plantar angulation at the osteotomy site. The only technical problem that was associated with long-term complications was bone apposition of less than 50% which may have lead to a nonunion in one case and recurrence of deformity in another. Shortening of the hallux was observed in all cases secondary to the closing wedge osteotomy. Shortening can be limited if a minimum of bone is removed from the proximal phalanx. A mathematical analysis is presented in this paper which can be used to provide guidelines to osteotomy size so that a minimum of bone necessary for correction can be removed. The Akin procedure should be performed within certain guidelines. Rarely is an Akin procedure alone indicated for the correction of a hallux valgus deformity. In most patients the proximal phalangeal osteotomy needs to be performed in combination with some other procedure to correct all components of the hallux valgus deformity. Furthermore the procedure can be used with success in those patients who present with an essentially asymptomatic great toe valgus deformity at the metatarsophalangeal joint or the interphalangeal joint which causes symptoms and/or deformity to develop in the second toe.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1990

Recollecting events associated with victimization.

Subjects first completed social desirability and anxiety personality scales and then read a story about a woman meeting her brother for lunch. Some subjects were then told that the story involved sexual abuse. A week later all subjects took a multiple-choice memory test over the story. The results indicated that subjects categorized as repressors based on the personality scales had a lower proportion of negative than positive errors than did the nonrepressors, but only when they believed the story was about sexual abuse. However, repressors answered correctly as many items as did nonrepressors. The results were consistent with the idea that repressors remember as much about victimization experiences as do nonrepressors but are more likely to fill in the missing details of victimization experiences with positive reconstructions designed to reduce the over-all negative quality associated with victimization.

Adult↗
PubMed1990

Vascularity of the posterior tibial tendon.

Operative exploration of ruptures of the posterior tibial tendon has revealed a relatively constant site of damage just posterior and distal to the medial malleolus. It has been hypothesized that the stress that is applied to the tendon as it passes under the medial malleolus may compromise the vascularity of the tendon in this area, a process that is similar to that described for the supraspinatus tendon. In order to evaluate this possibility, we studied the vascularity of the posterior tibial tendon. We injected twenty-eight cadaveric limbs with an India ink-gelatin mixture and cleared them using a modified Spalteholz technique. The gross external and internal vascularity were drawn, and the specimens were photographed. The vascularity of the tendons was noted to be abundant at the osseous insertion and the musculotendinous function of the tendon. There was a zone of hypovascularity posterior and distal to the medial malleolus in all specimens. The results of this study suggest that relative avascularity and resulting degenerative changes may be predisposing factors in rupture of the posterior tibial tendon, and that they have important implications in terms of the operative management of the rupture.

Adult↗
PubMed1989

[Late results of sub-capital humerus fracture in children].

From 1980 until 1984 56 children with a subcapital humeral fracture were treated at the Department of Paediatric Surgery in Zürich. 42 of them could be followed-up 5 years after the accident, all showed a good result. In 21 children a simple immobilisation was successful. 8 cases needed a reposition of the fracture in anaesthesia and immobilisation. 11 cases needed further procedures, in 7 of them an osteosynthesis was done, in 4 cases an extension was necessary to hold the fracture position. One patient was treated primarily by open reduction and pinning of the fracture, another one by an extension. Both patients had polytrauma. The paper presents our long-term results and the different modalities of treatment are discussed in the light of our own results.

Adolescent↗
PubMed1988

Correlation between breast parenchymal patterns and mammographers' certainty of diagnosis.

The density of breast tissue on a mammogram may affect radiologists' diagnostic decisions. To evaluate possible correlations among breast parenchymal pattern and diagnostic confidence, six radiologists classified 655 mammograms as N1, P1, P2, and DY, according to Wolfe's criteria. Evaluation of radiologists' confidence interpreting the mammograms (1 = absolutely certain, 2 = fairly certain, 3 = uncertain), shows a significant correlation between decreasing diagnostic certainty and increasing complexity of the mammographic breast parenchymal pattern. That readers are less confident in their interpretation of P2 and DY breast parenchymal patterns has implications for the operation of breast cancer screening programs.

Breast↗