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Biomedical subjects

C Frey

Publications and source records attributed to C Frey.

At least 73 records · Page 4Linked to original sources
PubMed1987

[Long-term development of children with cerebral palsy. Follow-up at age 15].

In a retrospective longitudinal study we report on 60 children with cerebral palsy whose physiotherapy (after Bobath) lasted up to the age of three. Delayed psychomotor and speech development, numerous behaviour disorders and learning disabilities and a high rate of consulting the child psychiatrist, school psychologist or speech therapist prove that they are really children at risk. The children often cannot cope with the demands of normal school and attend special classes. Severity of CP becomes less, social class more important during the course of development. Three developmental types with different frequencies are described, followed by practical suggestions.

Adolescent↗
PubMed1987

Knee dysfunction secondary to dislocation of the fabella.

The fabella, a sesamoid bone in the lateral head of the gastrocnemius muscle occurring in 10% to 30% of individuals, is rarely considered a possible cause of knee dysfunction. When noted, the fabella is occasionally mistaken radiographically for an intraarticular ossified fragment; however, symptomatic conditions of the fabella have been well documented in the literature. This is a report of symptomatic dislocation of an enlarged fabella in a 37-year-old man. In a review of the literature of various lesions of the fabella, disability related to dislocation seems not to have been previously reported.

Adult↗
PubMed1986

Treatment of recurrent urinary tract infections: efficacy of an orally administered biological response modifier.

64 out-patients suffering from recurrent UTI were treated under double-blind conditions with one capsule daily of either the biological response modifier OM-8930 or the placebo for 3 months, followed by a 3-month observation period. Dysuria, bacteriuria, leucocyturia and antibiotic or chemotherapeutic consumption showed a significant reduction under OM-8930 in comparison with the placebo. As to the tolerance, a single case of allergic exanthema on the neck was observed in the OM-8930 group. Both the curative efficacy in the acute crisis and the consolidative efficacy in preventing further recurrences showed a highly significant superior effect of OM-8930 with respect to the placebo.

Adjuvants, Immunologic↗
PubMed1986

[Klinefelter syndrome: is early diagnosis by screening study necessary?].

Diagnostic procedures and care for patients diagnosed as Klinefelter's syndrome, as well as the patients' coping with this situation, are examined on the basis of two case reports. Specifically, the screening for X-chromatin positive males (buccal smear) is considered. Besides necessary diagnostic procedures as careful somatopsychological examination remains of utmost importance. In cases with etiologically unclear and genetically not explainable learning disabilities, especially with reduced capacity for verbalization, the sex-chromatin examination is indicated. Because of its possible effect as a "self-fulfilling prophecy", a newborn screening is not recommended. Treatment and care should take into account all aspects of somatic and psychic datas. Educational and supportive psychotherapy and pharmacotherapy (Testosteron) should be combined. Co-operation should be interdisciplinary.

Adolescent↗
PubMed1986

Sensitivity to non-acetylated salicylates in a patient with asthma, nasal polyps, and rheumatoid arthritis.

A woman experienced exacerbations of bronchial asthma after taking aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) for rheumatoid arthritis. On oral challenges, she developed an urticarial reaction after tartrazine; urticarial and bronchospastic reactions after salicylsalicylic acid; and urticarial and bronchospastic reactions after choline magnesium trisalicylate. Non-acetylated salicylates have been recommended for use in aspirin- and/or tartrazine-sensitive patients. The results of sensitivity studies of our patient indicates that such patients may also be sensitive to non-acetylated salicylates.

Albuterol↗
PubMed1985

[Glaucoma, ocular hypertension and diabetic retinopathy].

71 out of 4803 diabetics attending the special outpatient clinic for diabetic eye complications at the 1st Eye Department of the University of Vienna were found to be suffering from glaucoma. Ocular hypertension was observed in 717 cases. Neither the course of diabetic retinopathy nor the correlation between duration of diabetes mellitus and the manifestation of retinal changes differed from the findings in diabetics with normal ocular pressure. The hypothesis that increased ocular pressure in response to the topical application of steroids might be of beneficial influence on the course of diabetic retinopathy was not confirmed by these observations.

Diabetes Mellitus, Type 1↗
PubMed1985

[Recurrence of vasoproliferative activity after photocoagulation. A fluorescence-angiographic study].

Although photocoagulation is no cure for diabetic retinopathy, it slows down or, in favourable cases, prevents further progression. In order to achieve the desired therapeutic effect, photocoagulation has to include the ischaemic mid-periphery of the retina. Following a latency period of varying duration during which no further progression is evident either on ophthalmoscopic examination or fluorescein angiography, recurrence of neovascularization is observed in some cases. The therapeutic management entails additional panretinal photocoagulation, in particular at the periphery. The authors report on 75 patients who, following panretinal photocoagulation, were treated by additional argon-laser coagulation.

Diabetic Retinopathy↗
PubMed1985

Pancreatic pleuropericardial effusions. Fistulous tracts demonstrated by computed tomography.

Demonstration of the fistulous tract linking pancreatic pseudocysts to the mediastinum and pleural cavity has diagnostic and therapeutic implications. In four cases, pseudocyst drainage through the esophageal and aortic diaphragmatic crus into the mediastinum and pleural cavity was delineated by computed tomography. In two cases, significant pericardial effusions were demonstrated. Computed tomography offers an effective diagnostic method when treatment is dependent on anatomic localization of the disrupted pseudocyst and its intrathoracic drainage tract.

Adult↗
PubMed1985

[Extracapsular cataract operation with implantation of posterior chamber lenses following fistulating glaucoma operations].

In 78 eyes treated by different fistulizing procedures (57 by goniotrepanation or trabeculectomy, 13 by Elliot trepanation and 8 by iridencleisis) extracapsular cataract extraction with implantation of posterior chamber lenses was performed. A sector iridectomy had to be performed in about 40% of the eyes because of difficulties in dilatation of the pupils and posterior synechiae. Postoperatively the IOP was regulated in 83% of all eyes without additional topical medication; a second fistulizing procedure was only necessary in one eye. Complications such as keratopathies, posterior capsule fibrosis, and dislocations of the posterior chamber lenses were not found to be more frequent compared with nonglaucomatous eyes treated by extracapsular cataract extraction with implantation of posterior chamber lenses.

Aged↗
PubMed1985

[Initial clinical results on the problem of implantation of intraocular lenses in diabetes mellitus].

About 2% of the Austrian population suffer from diabetes mellitus, the incidence being higher in the 5th and 6th decades of life. As a consequence the number of diabetics requiring cataract surgery is relatively large. In recent years extracapsular cataract extraction with implantation of a posterior chamber lens has become the method of choice. The question under what circumstances implantation is indicated in diabetics and in which cases it is contraindicated is still under discussion. During the past 2 years extracapsular cataract surgery with implantation of a posterior chamber lens has been performed on 36 patients (42 eyes). The average period of observation ws 8.5 months. The patient material was analyzed in a retrospective study and the results of surgery are reported in this paper.

Aged↗
PubMed1985

Value of hyaluronic acid in the prevention of contracture formation.

Joint stiffness secondary to immobilization was inhibited by intra-articular hyaluronic acid injection in an experimental joint contracture in rabbits. Biochemical and biomechanical parameters were used to evaluate the joint stiffness after nine weeks of immobilization. In all treatments, hyaluronic acid reduced the measured stiffness in the contracture by approximately 50% as compared to the contractures of the untreated rabbits. In addition, hyaluronic acid prevented the loss of glycosaminoglycans (GAGs) (as measured by hexosamine), which normally occurs in untreated contractures. The results are related to a working hypothesis that intra-articular injections of drugs such as hyaluronic acid (Healon-R) will stimulate hyaluronic acid synthesis within the matrices of periarticular connective tissue (PCT). If the spacing and lubricating properties of the glycosaminoglycans could be maintained in the stress-deprived state, the "centripetal collapse" of the fibrillar matrix could be avoided, anomalous cross-links could be minimized, and more normal joint mechanics could be retained.

Animals↗
PubMed1984

Megacolon and neurofibromatosis: a neuronal intestinal dysplasia. Case report and review of the literature.

This study presents the case of a patient with neurofibromatosis and megacolon. A diffuse, but patchy abnormality of neural tissue was present throughout the colon, especially in the myenteric plexus, but also in the submucosal plexus, smooth muscles, and lamina propria. This consisted of (a) a marked decrease in the number of argyrophilic neurons within the myenteric plexus, enlargement and deformity of those neurons present, and a marked increase of nerve fibers and nerve tract size in the myenteric plexus; (b) a proliferation of neurons and nerve fibers within the smooth muscle and submucosa; and (c) a proliferation of nerve fibers within focal areas of the lamina propria. The relationship of this case to previously reported cases of neuronal intestinal dysplasia and plexiform neurofibromatosis is discussed. Surgical treatment may be necessary and the surgical options are reviewed.

Colonic Neoplasms↗
PubMed1982

Clinical problems in radiotherapy of carcinoma of the pancreas.

Since 1975, 94 patients with localized unresectable carcinoma of the pancreas have been irradiated using helium and heavier particles at the University of California Lawrence Berkeley Laboratory. Despite surgical exploration and an extensive diagnostic workup including radiological, nuclear medicine, and computer-assisted tomographic studies, many patients proved to have occult liver metastases manifested within 9 months post treatment. In addition, local and regional control of the primary neoplasm (approximately 20%) has been difficult to obtain even with doses of 6000 equivalent rad in 7 1/2 weeks. Gastric and biliary obstruction have required surgical bypass procedures since irradiation has not been successful in relieving obstructive symptoms. Evidence of gastrointestinal injury has been present in postradiation therapy in approximately 10% of patients, a figure which might be higher if more patients had a longer survival (average 10 months). Some patients require pancreatic enzyme supplementation because of pancreatic deficiency either secondary to tumor or treatment. Further improvement in local control and survival requires better diagnostic methods for evaluation of local and metastatic spread, improved therapy for local and regional disease, as well as therapy directed at occult liver metastases that are frequently present.

Adenocarcinoma↗
PubMed1981

Randomized study of 5-FU and CCNU in pancreatic cancer: report of the Veterans Administration Surgical Adjuvant Cancer Chemotherapy Study Group.

Between the years 1973-1977, 152 male patients from 28 participating Veterans Hospitals with histologically proven nonresectable cancer of the pancreas were randomized in a two-arm study. The treated group was to receive combination chemotherapy with 5-FU and CCNU, and the controls were to receive no chemotherapy. Both groups were comparable with respect to age, amount of weight loss, extent of histologically proved metastases, and operation performed. In the treatment group, drug therapy was begun between 10 and 60 days postoperatively. Intravenous 5-FU, 9 mg/kg, was administered on five consecutive days, and CCNU, 70 mg/m2, was given orally on the first day of each course. In the absence of toxicity, the course was repeated every six weeks for life; 146 drug courses were given. The incidence of toxicity was not great. One or more toxic reactions were reported for one-third of the drug courses administered, but for the most part, these were mild. The most frequent toxic reaction was vomiting in 17% of the courses, and hematologic toxicity-primarily leukopenia-in 15% of the drug courses. There was no evidence of a beneficial effect on survival from drug treatment in the group as a whole or in any subgroup analyzed. The median survival of the control group was 3.9 months, and of the drug-treated group, 3.0 months.

Adenocarcinoma↗