Biomedical subjects
Publications and source records attributed to C G Espínola.
A model polyether-based ion channel-like compound was rationally designed and synthesized. Macromolecules 1c-f were incorporated into phospholipid vesicles and shown to facilitate the transmembrane sodium transport.
[reaction: see text] A convergent design for the preparation of a polyoxyethylene-based channel molecule is presented, and the synthesis of the key unit 2 required for the projected construction is described. The essential elements of the design included face to face oriented macrorings spaced by rigid trans-fused oxanes. The strategy combines conformational predictability of C-linked oxanyl systems and ring-closing metathesis for the synthesis of crown ethers with engineerable ion-binding abilities.