PubMed Health⌕ Search

Biomedical subjects

C G Kardinal

Publications and source records attributed to C G Kardinal.

At least 91 records · Page 5Linked to original sources
PubMed1976

Chronic granulocytic leukemia. Review of 536 cases.

The Western Cancer Study Group (WCSG) retrospectively reviewed chronic granulocytic leukemia (CGL) diagnosed during 1960 to 1974 from 22 institutions. In 100 cases, patients had positive findings for the Philadelphia chromosome (Ph'+). In 426 cases karyotyping was not done (Ph'?). Ten patients had no Ph' chromosome (Ph'-). The ten Ph'- patients ranged in age from 8 to 85 years and in survival from 1 to more than 125 months. Their small number and heterogeneity precluded statistical analysis, but this notable heterogeneity of the Ph'- group may well be typical. Busulfan prolonged survival in the Ph'+ and Ph'? patients. Females and younger patients tolerated their disease better than males and older patients. Survival studies without reference to the Ph' status, treatment, age at diagnosis, and sex are probably not valid.

Adolescent↗
PubMed1976

Light chain disease: report of an atypical case.

A 50-year-old black man had the signs and symptoms of severe anemia. His bone marrow contained sheets of primitive cells that could only be conclusively identified as being of plasmacytic origin by electron microscopy. These cells produced only a small quantity of kappa light chain but did fluoresce when stained with immunofluorescent antikappa stain. His initial response to chemotherapy was dramatic, but after eight months his condition was refractory to all further attempts at treatment. This case supports the observation of Hobbs that patients with Bence-Jones myeloma may have a poorer prognosis than those with otherwise typical IgG or IgA myeloma.

Autopsy↗
PubMed1975

Reversible interstitial pneumonitis associated with low dose bleomycin.

A patient with nodular histiocytic lymphoma was treated with bleomycin; she later developed interstitial pneumonitis documented by lung biopsy. The dose of bleomycin producing this complication was lower than previously reported, and the pulmonary toxicity was apparently completely reversible.

Abdominal Neoplasms↗
PubMed1975

Procoagulant activity of platelets.

A simplified, semiautomated, quantitative method to evaluate platelet procoagulant activity was evaluated on plasma that contained widely divergent concentrations of platelets. When fewer than 100,000 platelets/cu mm were present, excellent correlation between platelet concentration and clotting time was noted, with correlation best in the range 30,000 to 100,000 platelets/cu mm. When platelets were present in concentrations greater than 100,000/cu mm, no alteration in clotting time as a function of platelet count was noted. These observations were consistent with clinical observations that patients with greater than 100,000 platelets rarely bleed and that those with fewer than 30,000 platelets bleed in an unpredictable fashion. The procedure appears to be of potential value in evaluation of patients for defects in platelet factor 3 release.

Blood Cell Count↗