Effect of pyrethroids on [3H]kainic acid binding to mouse forebrain membranes.
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Animals↗
Biomedical subjects
C G Staatz
Publications and source records attributed to C G Staatz.
The use of lymphocyte phosphoglucomutase as a genetic marker in bone marrow transplant recipients.
Lymphocyte phosphoglucomutase can be used as a genetic marker to document successful engraftment in bone marrow transplant recipients. Two patients who underwent marrow transplantation as a treatment for acute leukemia showed a change into donor-type isozyme pattern.
Acute Disease↗
Demonstration of cell surface antigens and their antibodies by the peroxidase-antiperoxidase method.
The unlabeled antibody enzyme method, using the peroxidase-antiperoxidase immunocomplex for labeling, was applied to freshly prepared viable lymphocytes to detect antibodies in individuals preimmunized by pregnancies or blood transfusions. The "sandwich" incubations and washing steps were carried out with cells attached to poly(L-lysine) glass slides, in order to facilitate the handling of the samples and to save antisera and time. In comparison to the lymphocytotoxicity test, the described method is more sensitive and able to detect additional antibodies. Our findings indicate that further investigation of the use of this test for the demonstration of cell surface antigens and their antibodies appears to be worthwhile.
Antibodies↗
Pyrethroid effects on operant responding and feeding.
The effects of permethrin, its cis and trans isomers, and deltamethrin on operant behavior and food intake were examined. Male Sprague-Dawley rats were trained to respond on a VI20 second schedule of food reinforcement. Rats were injected intraperitoneally with pyrethroids or their Emulphor vehicle 20 minutes prior to testing. Technical grade permethrin (15-60 mg/kg) produced a dose-related decrease in operant response rate. The 60 mg/kg dose decreased rates by 60%. Lower doses of cis-permethrin (30 mg/kg) and deltamethrin (2 mg/kg) also produced significant decreases in response rate. A 30 mg/kg dose of trans-permethrin was without effect. Food intake was also measured for 1.5 and 24 hour periods after tech-permethrin treatment. Food intake was decreased over both intervals by the 60 mg/kg dose. The results of these studies indicate that subconvulsive doses of pyrethroid insecticides can have significant effects on learned behavior and food intake.
Animals↗