Pyrethroid effects on operant responding and feeding.

A S Bloom; C G Staatz; T Dieringer

PubMed · 6877472

Pyrethroid effects on operant responding and feeding.

Abstract

The effects of permethrin, its cis and trans isomers, and deltamethrin on operant behavior and food intake were examined. Male Sprague-Dawley rats were trained to respond on a VI20 second schedule of food reinforcement. Rats were injected intraperitoneally with pyrethroids or their Emulphor vehicle 20 minutes prior to testing. Technical grade permethrin (15-60 mg/kg) produced a dose-related decrease in operant response rate. The 60 mg/kg dose decreased rates by 60%. Lower doses of cis-permethrin (30 mg/kg) and deltamethrin (2 mg/kg) also produced significant decreases in response rate. A 30 mg/kg dose of trans-permethrin was without effect. Food intake was also measured for 1.5 and 24 hour periods after tech-permethrin treatment. Food intake was decreased over both intervals by the 60 mg/kg dose. The results of these studies indicate that subconvulsive doses of pyrethroid insecticides can have significant effects on learned behavior and food intake.

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Animals Conditioning, Operant Dose-Response Relationship, Drug Feeding Behavior Food Deprivation Insecticides Male Nitriles Permethrin Pyrethrins Rats Rats, Inbred Strains Journal Article Research Support, U.S. Gov't, P.H.S.

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A S Bloom, C G Staatz, T Dieringer. Pyrethroid effects on operant responding and feeding.. https://pubmed.ncbi.nlm.nih.gov/6877472/

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