Biomedical subjects
Publications and source records attributed to C Goujon.
The authors present eight cases of hepatitis probably due to amodiaquine taken at a prophylactic dose. Seven cases were minor forms with vomiting, nausea and 3 to 8 fold rise in transaminases. One case had jaundice. The symptoms regressed when amodiaquine was replaced by chloroquine. An in vitro test done once was positive.
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Three cases of skin reactions that occurred in patients under oral administration of Piroxicam are reported here: one erythema-multiforme-like reaction and two cases of acute, pruriginous erythemato-papulous dermatitis, one of which with intraepidermal blister formation. No past history of skin disease could be formed; lesions spontaneously improved when the drug was stopped. Only in one patient, receiving Piroxicam and Fenoprofene, an acute nephritis was observed. The role of Piroxicam, a new non-steroid antiinflammatory agent in the pathogenesis of the skin reactions observed is discussed. However, the renal involvement formed in one case is likely due to Fenoprofene, as in previously reported cases.
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A child had both a congenital nevus unius lateris and a linear psoriasis of recent onset which first appeared localized to the nevus, and later became generalized. Histology of the psoriatic lesion overlying the nevus revealed the typical features of psoriasis and epidermolytic hyperkeratosis. Psoriasis and nevus have both disappeared with Ro 10.9359 therapy. Five similar cases of psoriasis overlying an epidermal nevus have been found in the literature. The epidermal nevus is a fertile site for the development of psoriatic lesions in a predisposed person. It is an example of the Köbner phenomenon. A wider definition of this phenomenon is suggested. The features of linear psoriasis are studied and we now believe that true linear psoriasis is not a distinct clinical entity and that previously reported cases correspond in fact to an inflammatory linear verrucous epidermal nevus (ILVEN).
Anti-keratin polypeptide sera (K.P.S) were obtained by immunizing guinea pigs with fibrous proteins from stratum corneum, which were acquired from normal human epidermis by m eans of S.D.S. polyacrylamide gel electrophoresis. After absorption with red blood cells and liver powder the sera were tested by indirect immunofluorescence technique on different substrates. Antibodies against polypeptides P1 and P2 of M.W. 67,000 and 62,000 dalton, respectively, were directed toward cytoplasmic Ag of keratinocytes of spinous and graunular layer of normal human and rabbit epidermis. No labeling could be detected in the basal cell layer. This finding is in favor of various differentiation stages of the keratinizing cells. P3 of M.W. 53,000 dalton induced low titre anibodies which labelled the whole epidermis, including the basal cell layer. The fourth polypeptide of M.W. 49,000 dalton seemed not to be immunogenic in such experiences. In tumors, such as basal cell carcinom,a squamous cell carcinoma, and warts, the expression of keratin antigens is markedly diminished. No analogy could be drawn between experimental keratin polypeptide antibodies and the human epidermal cytoplasmic antibodies which were detected in some patient sera.
We describe two patients with unusual neuro-ophthalmologic complications during long-term therapy with lithium carbonate given for bipolar affective disorder, "benign" intracranial hypertension in one, and downbeat nystagmus, with oscillopsia in the other. A review of the literature is proposed. Though rare, such neuro-ophthalmologic manifestations are worth being recognised since they usually disappear with cessation--when possible--of lithium therapy.