Biomedical subjects

C Henriksson

Publications and source records attributed to C Henriksson.

At least 37 records · Page 2Linked to original sources

PubMed1988

Pulmonary embolism in renal cell carcinoma with vena cava extension.

Of 18 patients with renal cell carcinoma extending into the inferior caval vein, 11 underwent nephrectomy and cavathrombectomy and were examined by pulmonary scintigraphy pre- and postoperatively. In 7 patients, who underwent non-radical surgery or no surgery at all and had died of generalized tumour, the postmortem examination reports were scrutinised. On pulmonary scintigraphy, altogether 6 patients (55%) were free from perfusion defects preoperatively. Between the pre- and postoperative examination, perfusion defects appeared, disappeared, varied in size or were unchanged. Only 4 patients (36%) had acquired new defects. The total number of defects preoperatively was 14 and postoperatively 12. Most defects engaged less than a pulmonary segment and only 2 a whole segment. None gave clinical symptoms. No macroscopic pulmonary emboli were found in any patient at the postmortem examination.

Carcinoma, Renal Cell↗

PubMed1988

Percutaneous surgery for stones in pyelocaliceal diverticula.

The technique used for percutaneous extraction of stones in pyelocaliceal diverticula and the results of the procedure in 13 patients are presented. Nine patients have been free of their pre-operative symptoms, pain and/or bacteriuria, since removal of the stones.

Adult↗

PubMed1987

Partial protection against hyperbaric oxygen induced convulsions by dopaminergic agents in mice: possible involvement of autoreceptors?

In the present report we have investigated the effects of apomorphine, (-)3-PPP, L-DOPA and haloperidol on the elicitation of convulsions induced in mice by exposure to oxygen at high pressure (HBO) (5 ata O2). It was found that the administration of apomorphine (0.025-0.1 mg X kg-1 s.c.), (-)3-PPP (4 mg X kg-1 i.p.) L-DOPA (200-400 mg X kg-1 i.p.) as well as haloperidol (0.25-2.0 mg X kg-1 i.p.) produced a significant protection against HBO-induced convulsions. Haloperidol was the only drug to produce a dose-dependent decrease in respiration, and this effect does probably explain the anticonvulsant effects observed. The low doses at which apomorphine was effective, and the effects produced by (-)3-PPP, indicate an effect mediated via DA autoreceptors. Alternatively, and more likely taking the effects of L-DOPA into account, the DA receptors involved are sensitive enough to disclose postsynaptic agonist properties of apomorphine and (-)3-PPP at the doses employed.

Animals↗

PubMed1987

Renal cell carcinoma with vena cava extension: diagnostic and surgical features of 41 cases.

Vena cava extension of renal cell carcinoma was diagnosed in 33 men and 8 women, 29 of whom had right-sided and 12 left-sided tumours. Angiography was performed in all and cavography in most patients. Computed tomography was available in 16 cases. The tumour thrombus did not reach the diaphragm in 32 patients, and extended above it in 9 cases. Macroscopically, complete cavathrombectomy was performed in 33 patients. All tumours except one were of high grade type (grades III and IV). Serum creatinine and liver enzymes were normal at the first postoperative check-up. The 5-year-survival rate in patients subjected to complete cavathrombectomy was 24%. The 5-year-survival was 33% in patients whose tumours extended to below the diaphragm, 0% in patients whose tumours extended above the diaphragm (NS), 33% in grade III tumours and 0% in grade IV tumours (NS), 33% in patients without evidence of metastases and 0% in patients with preoperative metastases (NS).

Adult↗

PubMed1986

Amphetamine as a protective agent against oxygen-induced convulsions in mice.

Male mice exposed to hyperbaric oxygen (HBO) at 4.5 ATA O2 exhibit a number of toxic symptoms including convulsions, diminished respiration and an acoustic reaction controlled by the central nervous system. To study whether stimulation of the nervous system could offer protection against the convulsions, mice were injected i.p. with various doses of d-amphetamine before HBO. At a dose of 1.0 mg X kg-1 of d-amphetamine the mice could stay at 5 ATA O2 without convulsions about three times as long as those injected with saline only. At high doses, 4 and 8 mg X kg-1, there was a weak protective effect or the time to convulsions was shortened. Amphetamine increases the release of dopamine in the brain and it is possible that the mechanisms of protection against HBO induced convulsions are involved in that process. The degree of protection, however, depends on the dose; therefore, it also is supposed that amphetamine in low doses acts on the autoreceptors with a presynaptic effect, which in this case is protective against the convulsions without affecting the respiration.

Animals↗

PubMed1985

Central 5-HT and the respiratory response to acoustic stimulation in awake rats: effects of PCPA, 5-HTP and 8-OH-DPAT.

It was found that PCPA (4 X 50-100 mg/kg) decreased the respiratory response to tone pulses (acoustic reaction), and this effect was antagonized by the administration of 5-HTP (25 mg/kg), after inhibition of extracerebral aromatic amino acid decarboxylase by means of benserazide (25 mg/kg). A further increase in the dose of 5-HTP, 50-100 mg/kg, in animals not treated with PCPA did not significantly affect the acoustic reaction. The putative 5-HT agonist 8-OH-DPAT produced a decrease in the acoustic reaction (but also at higher doses some desynchronization of respiration with tone). The administration of d-amphetamine, 0.5-2.0 mg/kg, resulted in an increase in the acoustic reaction. Thus, in the present experiment, using a simple sensory-motor response, 8-OH-DPAT behaves as a 5-HT antagonist and the results provide further support for mixed 5-HT receptor agonist/antagonist properties of this compound.

5-Hydroxytryptophan↗

PubMed1985

Streptozotocin diabetes in juvenile pigs. Evaluation of an experimental model.

Spontaneous diabetes in the domestic pig, an animal suitable for metabolic and endocrine studies and for experimental surgery, is extremely rare. In this study we have compared the diabetogenic response of various doses of streptozotocin in comparison to surgically induced diabetes. Streptozotocin in a low dose, 35 mg/kg body weight did not influence glucose metabolism while an intermediate dose, 85 mg/kg, resulted in a transient diabetic reaction. Streptozotocin, 100-150 mg/kg body weight, caused a complete and permanent diabetes. Animals made diabetic by means of pancreatectomy did not survive more than 10 days due to their poor general condition and diabetes. Streptozotocin induced diabetic animals survived with insulin treatment up to seven months. The results show that juvenile pigs made diabetic with 100-150 mg/kg body weight of streptozotocin may be useful in experimental work on glucose-, insulin- and C-peptide-metabolism in a large animal. Therefore it is potentially useful in pancreatic transplantation research.

Animals↗

PubMed1985

Function of human autologous kidney grafts after extracorporeal preservation with Sacks' II solution.

The function of 18 human kidney grafts was studied before and 3 months after autotransplantation without prior bench surgery on the parenchyma or the vessels. Kidney protection was accomplished by pre-treating the patient with mannitol and low molecular weight dextran solution and flushing the kidney with a Xylocaine-heparin mixture and cold Sacks' II solution. The mean cold ischaemia time was 239 min (range 140-345 min). The glomerular filtration rate (GFR) remained unchanged post-operatively in terms of both total and split kidney GFR. Proximal and distal tubular integrity, as studied by determination of beta2-microglobulin excretion and concentration ability respectively, was also preserved.

Adult↗

PubMed1985

Urodynamic consequences of a direct pyelocystostomy at autotransplantation of the kidney.

The urodynamic consequences of renal autotransplantation and pyelocystostomy were studied in 17 male and 3 female patients. The indications of the procedure were urothelial tumor of the upper urinary tract, remaining outflow obstruction after conventional pyeloplasty and recurrent stones. The mean observation time was 31 months (range 3-50 months). The micturition flow rate was unchanged. There was an insignificant increase in residual urine. No evidence of any clinically significant disturbance of the sensory or motor bladder innervation or reduction of the functional bladder capacity was found. Urethrocystography showed transient dilatation of calyces at micturition. Urinary tract infections, when present, had the same pattern as preoperatively. Thus, autotransplantation of the kidney with a wide, direct pyelocystostomy is consistent with essentially normal urodynamics of the transplanted renal pelvis and the bladder.

Adult↗

PubMed1985

Natural history of renal artery aneurysm elucidated by repeated angiography and pathoanatomical studies.

The findings from repeated angiographies in 16 female and 5 male patients with altogether 34 renal artery aneurysms were studied. The mean interval between the first and last angiography was 35 months. Seven patients had multiple aneurysms. Two to four angiographies were performed in each patient. They showed no change in 28 aneurysms and slight or minimal enlargement, thrombosis or calcification in the other 6. The clinical course was uneventful except for severe hypertension in 3 patients. No rupture occurred. Eight patients, of whom 5 had solitary, saccular aneurysms, were operated upon. Pathoanatomically, fibromuscular dysplasia or secondarily changed fibromuscular dysplasia was found in 7 of them. Four died of unrelated disease having been followed up for 55-204 months (mean 102 months). Nine were alive and symptomless at the end of follow-up 11-195 months (mean 97 months) after the first angiography. The study supports the view that the risk of rupture of a renal artery aneurysm is very small, and indicates that fibromuscular dysplasia is common even when the angiography shows solitary, saccular aneurysm only.

Adult↗

PubMed1985

Large rhabdomyosarcoma of the urinary bladder in an adult. Case report.

A 56-year-old woman presented with frequency of micturition, haematuria and cardiac decompensation. Intravenous urography showed a large bladder tumour and an expansive lesion in the left kidney. The bladder tumour, removed by TUR, was found to be a rhabdomyosarcoma, and the resected tissue weighed about 310 g. Bilateral, selective renal angiography revealed a large arteriovenous aneurysm in the right kidney and a solid malignant tumour in the left. The aneurysmal vessels were ligated and cystourethrectomy and left nephrectomy were performed 2, 3 and 10 months, respectively, after the TUR. The excised urinary bladder contained no resicual tumour. A renal cell carcinoma was found in the excised left kidney. The patient recovered well, and three and a half years after TUR of the rhabdomyosarcoma she is fully active, with normal renal function and no evidence of disease.

Female↗

PubMed1984

Treatment of urothelial tumors of the upper urinary tract by nephroureterectomy, renal autotransplantation, and pyelocystostomy.

Nephroureterectomy, renal autotransplantation, and pyelocystostomy have been performed in eight patients with urothelial tumors of the upper urinary tract. One patient had tumors in a solitary kidney, two patients had bilateral tumors, and five patients had unilateral tumors. Three patients have had recurrent calyceal tumors which were successively managed by the transurethral route. In one patient the kidney had to be removed after 4.5 years because of infiltrating tumor recurrence. Two patients died; the renal pelvis of the graft was tumor free at autopsy in both cases. The other five patients are alive and free from tumor recurrence. The procedure implies increased radicality compared with conventional conservative treatment and simplified follow-up. It may be considered in patients with bilateral tumors or tumors of a solitary kidney, and in selected patients with unilateral low-grade, low-stage tumors.

Aged↗

PubMed1984

Widespread urothelial tumor treated with bilateral nephroureterectomy, cystectomy, autotransplantation of one kidney and pelvioileocutaneostomy.

We report on a man who had recurrent low grade noninvasive bladder tumors for 8 years and an increasing number of such tumors in both renal pelves and ureters for 3 years. Because of steady tumor progression, including obstruction of urine outflow from the right kidney, the tumors and as much urothelium as possible were removed. Right nephroureterectomy was performed initially. A month later left nephroureterectomy, cystectomy, extracorporeal pelvic resection and autotransplantation of the kidney to the pelvic cavity with urinary diversion to the skin using an isolated ileal loop were done. Convalescence was uneventful. Endoscopic examination 4 months postoperatively via the ileal conduit revealed no recurrences. The general condition of the patient after 6 months was excellent.

Aged↗

PubMed1984

Angiographically discovered, non-operated renal artery aneurysms.

Angiographies (a total of approximately 9 500) and patient records revealed 56 patients with renal artery aneurysm during the period 1960 to 1974. Fifteen patients were operated upon electively and 3 were lost for follow-up. Rupture occurred in four leading to acute nephrectomy. Thus, 34 patients were left for studies on the natural course. They were 29-82 years old (mean 58 years) at diagnosis and were followed for at least 90 months. Twelve were males and 22 females. The aneurysms had a diameter of 3-25 mm (mean 12 mm), were fusiform in 7 and saccular in 27 cases; 9 were calcified. Repeated angiographies were carried out in 7 patients at intervals of up to 73 months showing slight enlargement of one aneurysm, disappearance of another and no change in 5. Sixteen patients were alive at the end of the follow-up period 90-220 months (mean 157 months) after the first or only angiography. Eighteen patients died after 2-204 months (mean 84 months), 14 of cardiovascular disease unrelated to the renal arteries, 3 of malignant tumour and one of pancreatitis. Autopsy in 12 patients did not show rupture of any renal artery aneurysm. Thus, in a considerable number of patients the disorder was uncomplicated and compatible with a long life.

Adult↗

PubMed1984

Surgical removal of bone and muscle metastases of renal cancer.

Fifteen men and six women with renal cancer underwent surgical removal of metastatic lesions in bone (19 patients) or muscle (two patients). The operation was carried out 2 years before nephrectomy/renal resection in two patients, on the same occasion in four, and 1-196 months after in 15. Surgical interventions of various kinds were undertaken, resulting in the loss of a lower limb in seven patients and an upper limb in one. The observed 5-year survival was 4 out of 10. Six patients were alive at follow-up, five of them without evidence of disease. Eight of the remaining 15 patients died of an unrelated disease (five without evidence of tumor); the other seven patients died of metastatic tumor disease. Local recurrence was diagnosed, and removed, in two patients. The results compare favourably with reports on surgically removed pulmonary metastases of renal cancer and seem to justify an aggressive attitude towards solitary bone and muscle metastases of renal cancer.

Aged↗

PubMed1983

Autologous renal transplantation and pyelocystostomy after unsuccessful pyeloplasty.

A total of 4 patients with persistent outflow obstruction after pyeloplasty for hydronephrosis was reoperated with renal autotransplantation and pyelocystostomy. All 4 patients had undergone an unsuccessful Anderson-Hynes pyeloplasty and 2 also had had a second operation. All patients had relief of pain, normalization of urine outflow and improved renal function during an observation of 27 to 37 months. Occasional asymptomatic bacteriuria occurred in 2 patients. Thus, renal autotransplantation and pyelocystostomy may be considered a useful and safe method to eliminate persistent outflow obstruction after unsuccessful pyeloplasty.

Adult↗

PubMed1983

Cholesteatoma of the renal pelvis treated by extracorporeal surgery and autotransplantation with pyelocystostomy.

We report on a patient who had had recurrent renal stones on the right side for 37 years. At the sixth lithotomy the diagnosis of cholesteatoma of the renal pelvis was discussed. After another recurrence of stones and a pelvic lesion nephrectomy was considered. However, the kidney still had 60 per cent of total renal function and the other kidney also harbored stones. Therefore, extracorporeal exploration was performed. The stones and keratin masses were removed from the pelvis and frozen section showed no malignant changes. The kidney was reimplanted in the ipsilateral iliac fossa with end-to-side anastomosis to the external iliac vessels and a wide direct anastomosis between the pelvis and the bladder. At followup 2 months postoperatively the patient was well. Autotransplantation with pyelocystostomy facilitates free passage of recurrent stones and keratin fragments, and allows for future transurethral control of the renal pelvis. Thus, the procedure is well suited for the treatment of cholesteatoma of the renal pelvis.

Cholesteatoma↗

PubMed1983

Transplantation of isolated pancreatic islets: current status and prospects.

Complete and permanent reversal of diabetes by transplantation of isolated pancreatic islets has been repeatedly demonstrated experimentally, whereas islet isolation and transplantation in man are associated with largely unsolved problems: the standard isolation procedure including disruption of acini and collagenase digestion is ineffective. Improvement of the islet yield is currently obtained in animal and human trials by using substances selectively acting on exocrine tissue and others protecting the islets at the isolation as well as in tissue culture media. Islet tissue banks and repeated transplantations seem to be realistic also in man. Islets are advantageously implanted intraportally in the liver. They are rejected soon without protection or efficient immunosuppression. Intense research concerns islet-containing diffusion chambers, macrophage suppression, new immunosuppressive agents and induction of immunological tolerance. A successful solution of the technical and immunological problems will aggravate a shortage of donor tissue, already noticeable in the experimental work: this will make the recipient selection crucial.

Animals↗