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Biomedical subjects

C Henriksson

Publications and source records attributed to C Henriksson.

53 records · Page 3Linked to original sources
PubMed1983

Autologous renal transplantation with direct pyelocystostomy in the treatment of recurrent renal calculi.

Six male patients with severe recurrent urinary calculus disease underwent renal autotransplantation with direct pyelocystostomy to allow spontaneous passage of stones. The only serious complication was an early renal vascular thrombosis with graft loss in one patient who had been operated on three times before with ipsilateral partial resections for nephrolithiasis. The other five patients did well (observation time 4-34 months). Their renal function has remained unchanged. Autotransplantation with direct pyelocystostomy should be considered in patients with multiple recurrent stones of the upper urinary tract, especially when some degree of obstruction has developed or when other predisposing anomalies prevail.

Adult↗
PubMed1982

Urethrovaginal and vesicovaginal fistula. A review of 29 patients.

During an 11-year period 29 women were treated for 6 urethrovaginal and 24 vesicovaginal fistulae. In all patients the urethrovaginal fistula was preceded by an operation for a benign lesion. Of the 24 patients with vesicovaginal fistulae 11 had a benign and 13 a malignant primary disease. Endoscopy, vaginal examination and IVP provided in most cases sufficient information with which to establish a diagnosis. The urethrovaginal fistulae were operated on either by a vaginal approach (3 patients); two recurrences occurred but healed after reoperation. Of the 24 patients with vesicovaginal fistulae, 14 underwent a combined operation usually including omentum interposition, while 10 underwent primary diversion. Primary cure ensued after 9 of 14 combined operations; recurrences were operated on by a combined approach in 2 patients, vaginal in one and with fibrin occlusion in one. Eight of the 10 patients who underwent urinary diversion had a malignant disease. A vaginal approach in recommended at the primary reconstruction of urethrovaginal fistulae, whereas a combined suprapubic and vaginal approach is recommended in vesicovaginal fistulae as well as in recurrent urethrovaginal fistulae.

Adult↗
PubMed1981

Basal cell carcinoma in children. Case report.

Clinical and pathoanatomic features of two children with basal cell carcinoma, an extremely uncommon disease in childhood, are reported. Clinically these lesions had a benign appearance, similar to a foreign body granuloma and an intradermal naevus, respectively, but histological examination showed a picture typical of basal cell carcinoma. The tumours were radically treated and no recurrence occurred during an observation time of 12 and 42 months, respectively.

Adolescent↗
PubMed1979

Successful kidney transplantation in a man with Dacron "trouser" prosthesis.

The case history of a male patient, 62 years old, in preterminal uremia at transplantation with a cadaveric kidney is described. Twelve years before the transplantation he was operated on because of an aortic aneurysm where the abdominal aorta and both iliac arteries were substituted with a Dacron prosthesis. The kidney was anastomosed to this vessel substitute and functioned excellently for more than five years and the patient was completely rehabilitated.

Aorta, Abdominal↗
PubMed1978

Collagenase isolation and 45Ca efflux studies of human islets of Langerhans.

22 human pancreases were removed soon after circulatory arrest from donors aged 15--63 years. Part of the pancreas was used for isolation of islets by the collagenase technique. The mean yield +/- SEM, expressed as the number of islets isolated from 4 g pancreas was 79 +/- 15. The yield varied considerably even when the pancreas was removed immediately after circulatory arrest and the histology was normal, and there was no correlation with the age of the donors. The islet content of insulin (ng/microgram dry islet) was 8.5 +/- 1.2 (mean +/- SEM). Isolated islets were loaded with 45Ca in the presence of 20 mM glucose and placed in a perfusion apparatus for further studies of the 45Ca washout. The decrease of washout of radioactivity in Ca2+-deficient medium offers support for the existence of a Ca2+-Ca2+ exchange process. When added in a concentration of 20 mM, glucose tended to stimulate 45Ca efflux in perfusion medium of ordinary ionic composition but inhibited this process when the medium was deficient in Ca2+. Exposure to the calcium ionophore X-537A resulted in immediate stimulation of of 45Ca efflux from human islets as previously observed for islets from rats and mice. This suggests that Ca2+ has a direct regulatory role for insulin release also in humans.

Adolescent↗
PubMed1978

Repeated isologous transplantation of islets of Langerhans in the diabetic rat.

The metabolic response to repeated isologous transplantation of isolated pancreatic islets was studied in 11 streptozotocin-diabetic AGUS rats. The islets were isolated with collagenase and transplanted intra-portally in batches previously found to be quantitatively insufficient for reversal of the diabetic state. Primary transplantation caused a slight improvement whereas retransplantation with the same number of islets three weeks later was followed by normalization of blood glucose, plasma insulin, urine volume and urine glucose per 24 hours during a three-month observation period. Repeated isologous transplantation of isolated pancreatic islets has an additive effect on the metabolism in that two insufficient tissue doses correct streptozotocin induced diabetes in the rats.

Animals↗
PubMed1977

Metabolic response to isologous transplantation of small numbers of isolated islets of Langerhans in the rat.

Pancreatic islets from adult donors were transplanted intraportally into 32 inbred, adult AGUS rats with streptozotocin diabetes. The islets were isolated with collagenase and counted individually. A relationship between the number of islets transplanted and the metabolic response could be demonstrated. Transplantation of less than 200 islets did not change the diabetic state. Rats receiving 200-220 improved, while recipients of 240-800 islets all exhibited normal values of blood glucose, plasma insulin, urine volume and urine glucose. The glucose tolerance, however, remained abnormal in all animals.

Animals↗
PubMed1977

Use of trypsin for isolation of islets of Langerhans in the rat.

A new technique for pancreatic islet isolation, based on trypsin administered into the pancreatic duct system and a reduced amount of collagenase for digestion of the removed and chopped pancreatic tissue, yielded viable islets as judged by the metabolic response of 27 inbred, streptozotocin-diabetic rats after intraportal transplantation of the islets: all recipients of greater than 240 islets normalized their blood glucose, plasma insulin, urine volume and urinary glucose. The number of islets isolated was the same as with the conventional collagenase technique.

Animals↗
PubMed1977

Viability of the islets of Langerhans after warm ischemia as judged by isologous transplantation.

The influence of warm ischemia on pancreatic islet viability was studied by means of 63 isologous transplantations in adult AGUS rats. The pancreases were harvested 0, 20 and 40 min after circulatory arrest. The islets were isolated with collagenase and transplanted intra-portally in known numbers into streptozotocin-diabetic recipients. The islet-dose-metabolic-response relationships in three groups of recipients were compared. No significant difference was found in the quantitative yield. The smallest number of islets which reversed diabetes increased by 25% after a period of warm ischemia regardless of its duration.

Animals↗
PubMed1975

Renal transplantation in children.

From July 1967 to September 1974, 26 kidney transplantations were carried out in 16 children aged 6 to 17 years, in Gotherburg. The average age at the primary transplantation was 12 years and average body weight 29.7 kg. Five patients had familial juvenile nephronophthisis, 5 chronic glomerulonephritis, 5 chronic pyelonephritis, and one bilateral Wilms's tumour. Four patients were predialytic. Fourteen grafts came from living related donors. The surgical technique was standard as was the immunosuppression with azathioprine and cortisone; exceptionally antilymphocyte globulin was used. Thirteen patients were alive in September 1974, observed 2-65 months, 8 with a normal serum creatinine, 3 with moderately elevated serum creatinine, and 2 on hemodialysis. The 6- and 12-month survivals of patients are 100% and 93% respectively. Normal growth and full rehabilitation in recipients of functioning grafts make renal transplantation justified as a therapeutic procedure in terminally uremic children.

Adolescent↗
PubMedDate not supplied

Computed tomography after percutaneous renal stone extraction.

Eighty patients were examined with computed tomography (CT) of the kidney and the retroperitoneal space after percutaneous stone extraction. Most examinations were done within a week after the operation. The morphologic changes were usually small or none. In 7 patients minor renal or perirenal fluid collections were found. Their operations had been complicated by bleeding or leakage. In 66 patients CT was compared with conventional radiographs. Residual stones were more often detected by CT. They were usually small. Percutaneous renal stone extraction is considered a safe and efficient method.

Adolescent↗
PubMedDate not supplied

Artery steonsis in renal transplantation.

Twenty-two stenoses were discovered at a re-examination of 958 routine angiographies of 367 transplanted kidneys. Two separate types of stenosis could be distinguished- a short one localized to the anastomosis appearing immediately after the transplantation, and a long one distal to the anastomosis appearing three weeks or more after the operation. Hypertension did not appear until the stenosis had reduced the vascular diameter more than 60%. Severe hypertension requiring reconstructive surgery was caused by the long type of stenosis more often than by the short one.

Humans↗