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Biomedical subjects

C J Fox

Publications and source records attributed to C J Fox.

6 recordsLinked to original sources
PubMed1994

Fluorescence-based signal amplification technology.

The ELF alkaline phosphate substrate can be used to fluorescently label a wide variety of biological targets. This substrate yields a bright, photostable yellow-green fluorescent precipitate at the site of enzymatic activity. ELF labeling can be as much as 40 times as bright and hundreds of times as photostable as labeling with conventional fluorophores and yields signals capable of very fine submicroscopic resolution. Signal development is also extremely rapid, making the signal amplification technology well suited for applications such as RNA in situ hybridization.

Alkaline Phosphatase↗
PubMed1991

Treatment of systemic vasculitis with pooled intravenous immunoglobulin.

The therapeutic effect of a course of high-dose, pooled, intravenous immunoglobulin (IVIg) on disease activity and circulating antineutrophil cytoplasm antibodies (ANCA) was investigated in 7 patients with systemic vasculitis. 5 had active disease despite conventional immunosuppression, and 2 had not received any treatment. All 7 had clinical improvement, which was sustained in 6 and transient in 1. The fall in ANCA concentrations to a mean of 51% of the pre-treatment values was maintained during follow-up. C-reactive protein concentration also dropped considerably. IVIg seemed to confer a useful therapeutic effect without adverse reaction.

Adult↗
PubMed1984

Teaching developmentally disabled persons how to react to fires.

Four elements of fire reaction are delineated: investigating, reporting, suppressing, and evacuating areas in which fires are present. Important issues in the acquisition, maintenance, and generalization of fire reaction skills for developmentally disabled persons are identified and reviewed. Learning-based treatment strategies and fire safety literature relevant to the authors' concerns are reviewed. The authors suggest that behavioral research on training should be congruent with fire safety experts' recommendations on fire reaction skills.

Accident Prevention↗
PubMed1977

Blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes.

Glomerular capillary basement membrane thickness (BMT) was measured in 23 rats which had had streptozocin-induced diabetes for 14 months and in 12 age-matched controls. Diabetic rats were randomly allocated to different groups, either receiving no treatment or treated with a low carbohydrate diet or insulin, or both. Control rats were randomly allocated to a normal or low carbohydrate diet. Among the diabetic rats mean plasma glucose concentrations for the groups ranged from 27-4 mmol/l (494 mg/100 ml) in the untreated rats to 9-8 mmol/l (177 mg/100 ml) in those receiving both a low carbohydrate diet and insulin. A highly significant positive relation was found between BMT and plasma glucose concentration for individual rats. When BMT was corrected for body weight a similar relation was observed.

Animals↗