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Biomedical subjects

C Jansen

Publications and source records attributed to C Jansen.

At least 73 records · Page 4Linked to original sources
PubMed1991

Urinary tract injuries in multiply-injured patients: a rational guideline for the initial assessment.

In a retrospective study involving 866 multiply-injured patients we demonstrated urinary tract injuries in 72 patients (8.3 per cent), 17 (2 per cent) of which were serious. Haematuria was a frequent finding in multiply-injured patients. In patients with serious lesions of the urinary tract, more than 35 RBCs/HPF in the sediment or macroscopic haematuria were found. All major injuries were demonstrated by the emergency intravenous urogram. Ultrasonography demonstrated contusions of the kidney or bladder and ruptures of the kidneys, but was not reliable in diagnosing ruptures of the bladder. Of 155 patients with a pelvic fracture 13 (8 per cent) had lower urinary tract injuries. In all these patients the fracture was located in the pubic arch. If a retrograde urethrogram was performed in these patients all urethral lesions were detected. We propose a rational guideline, which guarantees diagnostic accuracy of serious injuries of the urinary tract after blunt trauma, while interfering as little as possible with the resuscitative and diagnostic procedures in severely injured patients.

Hematuria↗
PubMed1991

Lip-length and snout indices in Bell's palsy. A comparison with the House grading system.

The lip-length (LL) and snout (S) indices provide information on peri-oral muscular function. They were determined in 18 patients suffering from Bell's palsy and compared with the results obtained by scoring according to the House grading system. A high correlation was found. LL and S indices are continuous variables, which facilitates their statistical evaluation. Results of the House scoring system are given in an ordinal scale and reflect overall facial muscular function. It is concluded that the indices and the House scoring system produce a different kind of information, but they are complementary to each other in the assessment of facial muscular function.

Facial Muscles↗
PubMed1991

[Increasing compartment pressure in tibial intramedullary nailing. A phenomenon inherent in the therapy?].

At the Department of Surgery of the Bergmannsheil Hospital, a total of 58 patients treated with intramedullary nailing were reviewed with reference to the condition of the soft tissue. During intra- and postoperative treatment a bilateral fasciotomy was required in 8 patients. The subfascial pressure in the deep flexor compartment measured in 11 patients during secondary closed placement of intramedullary nails showed a slight increase of pressure in the deep flexor compartment from 8 mmHg to 40 mmHg after extension of the leg positioned on the operating table. After reduction the pressure increased significantly, from 50 mmHg to 80 mmHg. The postoperative pressure measured after 20 min was less than 50 mmHg in 9 patients. In 2 patients with manifest compartment syndrome (compartment pressure greater than 50 mmHg) immediate fasciotomy was required. Besides commonly known traumatic effects, parameters inherent in the therapy caused an increase in compartment pressure were critically reviewed with reference to their clinical relevance. The reasons for an increase in compartment pressure during closed placement of intramedullary nails in the lower leg are high position of the leg (hydrostatic effect), stretching of the soft tissue by reduction (decrease of volume), and possibly hematoma with outflow into the deep flexor compartment (increase of content).

Adolescent↗
PubMed1991

The reconstruction of the sound conductive mechanism: a new concept.

Heterologous tympanoplasty using the collagen-serosa that is prepared in a special way has been performed for over 20 years with good success. The membrane is well tolerated as a platform for the overgrowing lining and a drum head of three layers is formed. The newly devised tympanic prosthesis seems to be very useful so far. Experiences and results will be discussed in future.

Animals↗
PubMed1990

Lip-length and snout indices: methods for quantitative assessment of peri-oral facial muscle strength.

Two simple bedside methods for the assessment of perioral muscle function are described. Using a marking gauge, the width of the mouth can be measured easily and accurately. Lip-length (LL) and snout (S) indices are expressions of the degree to which the width of the mouth can be lengthened or shortened. Facial muscle weakness as present in patients with various neuromuscular diseases results in low values for both indices. LL- and S-indices are measured by 3 observers in 19 healthy volunteers. Interobserver variation is negligible for the LL-index and large for the S-index. Intraobserver variation is moderate for both indices but slightly smaller for the LL- than for the S-index. The LL-index is suited for the assessment of changes in peri-oral musculature in longitudinal investigations.

Adult↗
PubMed1990

[An x-ray computed tomography study with radiographic splints in implant evaluation].

CT-Scan provide a powerful diagnostic tool in the presurgical evaluation for endosseous implants. This article overviews a computer assisted system combined with a "marked radiographic stent" and a "surgical stent". The technique evaluates the ideal number, location and direction of the implants for a successful treatment.

Dental Implantation, Endosseous↗
PubMed1989

An animal model of hearing loss from alpha-difluoromethylornithine.

alpha-Difluoromethylornithine is a new antineoplastic and antiparasitic drug that inhibits the synthesis of polyamines. It causes a sensorineural hearing loss in humans. We have established an animal model for alpha-difluoromethylornithine-induced hearing loss. The time course for onset and recovery of the hearing loss in animals was similar to that seen in humans. Electrophysiologic and histologic data suggest that the anatomic site of alpha-difluoromethylornithine-induced hearing loss is the organ of Corti. Unlike other drugs with ototoxic effects, the specific enzymatic site of action of alpha-difluoromethylornithine is known, making it a potentially important tool in auditory research.

Animals↗
PubMed1987

The binding of the cyclic AMP receptor protein to synthetic DNA sites containing permutations in the consensus sequence TGTGA.

The binding of the cyclic AMP receptor protein (CRP) to symmetrical synthetic DNA-binding sites was investigated with a gel-retardation assay. A set of ten different sequences was employed, comprising all base permutations at positions 2, 4, and 5 of the consensus sequence 5'(TGTGA)3'. We show that: (i) CRP has a higher affinity for the completely symmetrical site than towards the lac wild-type site; (ii) base substitutions at position 2 lead to either a complete loss of specific CRP binding (G----C), a reduction in specific CRP binding (G----A) or only marginal effects on specific CRP binding (G----T); (iii) changes at position 4 abolish (G----C; G----A) or reduce (G----T) specific CRP binding; and (iv) base permutations at position 5 reduce specific CRP binding, but never completely abolish it. Thus position 4, and to a lesser extent position 2, in the DNA consensus sequence are the most crucial ones for specific binding by CRP.

Base Composition↗
PubMed1987

Decreased monocyte production of interleukin-1 and impaired lymphocyte proliferation in atopic dermatitis.

We studied lymphocyte proliferation and subsets in ten atopic dermatitis (AD) patients and ten healthy controls. In addition, monocyte production of interleukin 1 (IL-1) was investigated. Mean numbers of total T cells, T-cells subsets, and B cells did not significantly differ between AD patients and controls even though the patients had slightly decreased amounts of suppressor T lymphocytes. Proliferative responses of AD patients to purified protein derivative of tuberculin (PPD), concanavalin A (ConA), or allogeneic cells did not significantly differ from those of healthy controls at optimal stimulant concentrations. In contrast, at suboptimal concentrations, AD patients showed a diminished response to all of these stimulants. Monocytes from AD patients elaborated clearly less IL-1 than those from healthy controls.

Adult↗
PubMed1986

[Retraction pocket as a potential for cholesteatoma recurrence].

About 40% of all recurrent cholesteatomas are caused by retraction pockets in so called intact canal wall techniques. The author points out that in almost all of his publications the satisfactory closure of all defects of the posterior bony canal wall has been mentioned. Nevertheless it took about 15 years before cartilage reconstruction of all kinds of defects could be performed. Details of the technique are demonstrated by means of drawings. The practice of cartilage reconstruction as a routine procedure in cases with defects of the posterior bony wall will show that the rate of retraction pockets will go down in the very near future.

Cartilage↗