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Biomedical subjects

C K Low

Publications and source records attributed to C K Low.

52 records · Page 3Linked to original sources
PubMed1995

Long-term results of free vascularized fibular graft. A clinical and radiographic evaluation.

Seven patients who had free vascularized fibular grafts for bone defects > 6 cm (mean, 16.6 cm) were studied retrospectively. There were 5 cases of tumor, 1 pseudoarthrosis, and 1 chronic osteomyelitis. The average followup period was 9.2 years (range, 5.2-11.3 years). Of the 5 patients with grafts to the lower limb, 1 showed a 30% reduction in bone width as seen on anteroposterior radiographs, whereas 4 patients had increases ranging from 44% to 100% (average, 66%). There were 4 graft stress fractures, of which 1 developed eventual shortening of 2.5 cm. One graft had pseudoarthrosis involving the proximal graft-host junction that required secondary procedures with autogenous cancellous bone grafting, with eventual limb-length shortening of 5 cm. All other graft-recipient junctions healed primarily. The Functional Evaluation Score ranged from 60% to 100% of normal function (mean, 85%). Three patients were able to return to sports participation. Mild weakness of the extensor hallucis longus in the donor limb was observed in 5 patients. Two patients had mild loss of plantar flexion, and 4 had limitation of dorsiflexion affecting the ankle of the donor limb.

Adolescent↗
PubMed1995

Results of closed intra-articular calcaneal fractures treated with early mobilisation and without reduction.

Between January 1987 and December 1989, a retrospective study was done of 42 patients with 56 closed intra-articular calcaneal fractures treated with no reduction and early mobilisation at the Department of Orthopaedic Surgery, Toa Payoh Hospital. There were 12 left, 16 right and 14 bilateral fractures. Using the Creighton-Nebraska Health Assessment for calcaneal fractures, 38 (67.9%) fractures were rated as excellent and good and the average follow-up period was 3.2 years. Thirty-five (83.3%) of the patients were able to work after an average interval of 4.5 months. The complications included residual pain in 34 (60.1%) fractures, heel deformity in 40 (71.4%), foot swelling in 31 (55.4%) and limitation of subtalar movement in 35 (62.5%). Early osteoarthritis of the subtalar joint was noted in 5 (8.9%) comminuted fractures and was associated with poor results.

Activities of Daily Living↗
PubMed1994

Social aspects in patients following proximal femoral fractures.

Between January 1989 and December 1990, a study was conducted on the social aspects of 123 patients admitted to the Singapore General Hospital, Department of Orthopaedic O, with proximal femoral fractures. Twenty-three patients passed away, leaving 100 patients for review at 2 years post-fracture. Of the 20 social functions evaluated, less than 60% improvement was observed in 6 lower limb dependent activities. Before fracture, 82 patients were independent and 83 were ambulating without aids. After fracture, improvement occurred progressively and reached a plateau at 1 year with 62 (75.6%) patients independent and 41 (49.4%) patients ambulating normally. All the patients stayed in their own home before fracture and 90 (90%) patients returned to their home after their discharge. Of the 59 patients who were unable to ambulate without aids, 21 had visual problems, 9 had cerebrovascular accident and 8 had both problems.

Accidental Falls↗
PubMed1994

De Quervain's tenosynovitis and ganglion over first dorsal extensor retinacular compartment.

Between 1988 to 1991, 80 cases of de Quervain's disease were managed at the Department of Orthopaedic Surgery, Singapore General Hospital. Six of them had an associated ganglion over the first dorsal retinacular compartment. Five out of 6 cases had intracompartment injections of hydrocortisone and lignocaine but the treatment was not effective in relieving the pain of de Quervain's tenosynovitis. All 6 cases had excision of the ganglion and decompression of the first extensor compartment. All the lumps were found arising from the dorsal aspect of the retinaculum and no intracompartment extension of the ganglion was found.

Female↗
PubMed1994

Reactivation of rheumatoid arthritis in knees following total knee replacement.

Between May 1985 and December 1990, 20 patients with rheumatoid arthritis had 34 total knee replacements performed. The mean follow-up period was 4.1 years and the range was 2.3 to 7.8 years. Five knees with total knee replacements (74.7%) in 4 patients were affected by activation of the rheumatoid process at an average postoperative interval of 28.6 months while the other 29 knees with total knee replacements (85.3%) remained in remission. Factors that appeared to have an influence on post total knee replacement rheumatoid activation included the activity of the disease preoperatively, and whether synovectomy was undertaken at surgery. Whether patella replacement was undertaken appeared not to have influenced postoperative reactivation of the disease. Using the Hospital for Special Surgery Knee score, total knee replacement in our cases gave excellent results. The complications included one knee with dislocation of the patella and another with infection.

Aged↗
PubMed1994

A surgical approach to the posterior interosseous branch of the radial nerve through the brachioradialis--a cadaveric study.

Twelve cadaveric upper limbs were selected to evaluate the surgical approach to the posterior interosseous nerve through the midline of brachioradialis. There were 6 right and 6 left upper limbs. The limbs were placed with forearm in mid-prone position and elbow at 90 degrees of flexion. The incisions were made 2 cm distal to the lateral condyle and along the midline of the brachioradialis towards the radial styloid process for an average of 4.7 cm. The lateral cutaneous nerve of forearm was found lying on the anterior third of the brachioradialis. The brachioradialis was split along the midline. The following structures were identified. The radial nerve branched into superficial radial nerve and posterior interosseous nerve at an average of 1.8 cm below the lateral condyle. The superficial branch descended along the anterior third of the brachioradialis. The posterior interosseous nerve passed beneath the arcade of Frohse at an average of 3.8 cm below the lateral condyle. The radial recurrent artery was found crossing the posterior interosseous nerve at an average of 2.7 cm below the lateral condyle. The nerve to the extensor carpi radialis brevis originated from the radial nerve bifurcation or its branches at an average of 2.3 cm below the lateral condyle and entered the muscle at an average of 3.9 cm below the lateral condyle. The arcade of Frohse and the superficial head of supinator were divided to expose the entire posterior interosseous nerve.(ABSTRACT TRUNCATED AT 250 WORDS)

Cadaver↗
PubMed1994

Early results of total condylar knee arthroplasty.

A total of 109 consecutive total condylar knee replacements in 73 patients were assessed at one to eight years postoperatively. The average age at surgery was 66.9 years and the range was from 52 to 84 years. The primary disease was rheumatoid arthritis in 12 and degenerative osteoarthritis in 97 knees. Out of the 109 prostheses; 101 were Miller-Galante kinematic condylar type I or II prostheses, seven were Insall-Burstern type I or II and one was a Whiteside prosthesis. The fixation technique was hybrid (only the tibial prosthesis cemented) in 63, both components uncemented in two and both components cemented in 44 knees. One hundred and five (96.3%) knees showed significant improvement in the Hospital for Special Surgery score postoperatively. The average preoperative score was 48.1 and the postoperative score was 85.4. Sixty-four patients (100 knees) were satisfied or very satisfied with the result of surgery. One hundred and four (95.4%) knees had achieved either an improvement in the range of motion and/or deformity. Complications included loosening in four (3.7%) knees, infection in three (2.8%), dislocation of the patella in four (3.7%), periprosthetic fracture in one (0.9%) and severe lateral collateral ligamentous laxity in one (0.9%).

Activities of Daily Living↗
PubMed1993

The ratios of area of foot print to area of foot outline and diabetic sole ulcer formation.

The ratio of area of foot print to area of foot outline for each foot was studied in 50 normal and 70 diabetic subjects. The diabetic group was divided into 2 groups: 44 patients without and 26 patients with sole ulcers. The chief aim was to find a ratio that could predict ulcer formation. One hundred feet in the normal subjects had a mean ratio of 0.621 with a range of 0.51-0.72. The 88 non-ulcerated feet in the diabetic patients had a mean ratio of 0.611 with a range of 0.49-0.70. The difference was statistically not significant (p > 0.05). Thirty-two ulcerated feet in the 26 diabetic patients had a mean ratio of 0.580 with a range of 0.47-0.68. The difference between the ulcer and the non-ulcer group was statistically significant (p < 0.01). Twenty non-ulcerated feet in 20 diabetic patients with unilateral involvement had a mean ratio of 0.60 with a range of 0.50-0.69. The difference between the ulcerated and non ulcerated feet in these 20 unilateral involved patients was also statistically significant (p < 0.01). The sole ulcers in our study were distributed mainly beneath the metatarsal heads and calcaneum. Analysis of the foot prints revealed multiple dark print areas. They were at the locations corresponding to the above bony prominences. As these bony prominences were high pressure points, the dark print areas could serve as crude indicators of excessive pressure. The diabetic ulcer group had smaller mean ratio and the reduction of the contact area could contribute to the formation of sole ulcers.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1991

Results of total hip replacement in systemic lupus erythematosus.

Ten total hip replacements were performed between 1 June 1984 and 31 May 1989 in 6 patients who had systemic lupus erythematosus. All had avascular necrosis of the femoral head. The mean age at operation was 31.2 years with a range of 21 - 41 years. The mean follow-up period was 3.9 years with a range of 1.75 to 6.25 years. Mayo clinical hip ratings were excellent for all but one hip. Complications included transient sciatic nerve palsy in one hip and aseptic loosening of the femoral component in another.

Adult↗
PubMed1987

Comparison of several in vivo digestibility procedures to determine lysine digestibility in poultry diets containing heat treated meat and bone meals.

1. Three subsamples of a batch of meat and bone meal (MBM0) were heated at 150 degrees C for 1.5 h (MBM1.5), 3 h (MBM3) or 5 h (MBM5). 2. The MBM's were included in 4 wheat-gluten based diets, each limiting in lysine. 3. The lysine digestibility for each of the diets was determined using precision-fed intact adult cockerels and caecectomised adult cockerels, ileal cannulated adult cockerels, the ileal digesta and excreta of young growing chickens. 4. The results of the digestibility assays were compared with the relative amount of lysine available as determined by growth assay. 5. Comparison of the regression lines of digestible lysine (determined with the digestibility assays) on available lysine (determined by growth assay) indicated that while the magnitude of the digestibility values varied significantly (P less than 0.05) depending on the type of assay used, the differences in lysine digestibility as a result of heat treatment across the 4 diets was the same when comparing assays (the regression lines were parallel). 6. The results of each digestibility assay also correlated with relative digestibility values determined by growth.

Animal Feed↗
PubMed1986

Determination of amino acid digestibility using caecectomised and intact adult cockerels.

Four subsamples of meat and bone meal (MBM) were heated (150 degrees C) for 0, 1.5, 3 and 5 h and then incorporated into four individual diets (100 g MBM/kg diet). The diets were precision-fed to 10 caecectomised and 10 intact adult cockerels. The apparent amino acid digestibility (ApAAD) and true amino acid digestibility (TAAD) of the diets were determined by analysis of the excreta. The digestibility coefficients measured using caecectomised birds were lower than those determined with intact birds. Coefficients of digestibility were statistically examined by analysis of variance for the effects of bird type (caecectomised or intact), type of calculation (apparent or true) and diet (heat-treatment) with and without accommodation for individual bird variability. If individual bird variability was not considered in the analysis the bird type X diet interactions (P less than 0.01) included glutamic acid, tyrosine and serine. When individual bird variability was included in the analysis, significant (P less than 0.01) bird type X diet interactions occurred for aspartic acid, serine, glutamic acid, leucine, tyrosine and lysine and the precision of the data was markedly improved. Amino acid digestibility using the precision-feeding procedure is affected by the selection of either intact or caecectomised birds.

Amino Acids↗
PubMed1986

Comparison of amino acid digestibility using the ileal digesta from growing chickens and cannulated adult cockerels.

Meat-and-bone meal (MBM), which had been heated (150 degrees C) for 0, 1.5, 3 or 5 h, was used along with an indigestible marker in four diets which were fed to young growing chickens and adult cockerels fitted with ileal cannulae. The ileal digesta from each group of birds were sampled and the apparent amino acid digestibilities of the four diets containing MBM were determined. The apparent digestibility values from growing chickens were higher (P less than 0.05) than those from cannulated cockerels. Differences in apparent digestibility of amino acids between diets as a result of heat treatment were consistent for all amino acids when comparing both techniques, with the exception of glutamic acid and arginine.

Aging↗
PubMed1980

The pharmacokinetics of methimazole after oral administration of carbimazole and methimazole, in hyperthyroid patients.

1 Methimazole plasma concentrations were measured in two groups of hyperthyroid subjects after the oral administration of either carbimazole or methimazole. 2 With the HPLC method it was also possible to measure the concentration of a methimazole metabolite, 3-methyl-2-thiohydantoin in one patient. 3 Large interindividual differences were observed, especially within the carbimazole group. 4 Incomplete absorption of carbimazole could explain particular high apparent volumes of distribution and apparent clearances.

Administration, Oral↗
PubMed1980

The pharmacokinetics of methimazole in pregnant patients after oral administration of carbimazole.

1 A high performance liquid chromatographic (HPLC) method was used to study the pharmacokinetics of methimazole after oral administration of carbimazole to women in various stages of pregnancy. 2 In one patient it was possible to conduct the study in the first and third timesters: there was an appreciable increase in the apparent clearance of methimazole. 3 Based on the assumption of complete absorption and hydrolysis of carbimazole to methimazole the mean apparent clearance was found to be significantly higher in pregnant patients receiving 10 mg carbimazole than in non-pregnant patients receiving the same dose.

Administration, Oral↗