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C L Benhamou

Publications and source records attributed to C L Benhamou.

At least 73 records · Page 4Linked to original sources
PubMed1986

[Osteoarticular pathology, hypercalcemia and adrenal insufficiency. Analysis of 113 cases of adrenal insufficiency].

Rheumatologic manifestations, ectopic calcification and hypercalcemia of adrenal insufficiency (IS) were evaluated by a prospective study (S1) of 20 patients with IS and a retrospective analysis of 93 cases of IS (S2). When routine investigations were conducted they revealed very frequent osteoarticular lesions (19 of 20 cases, S1). Painful manifestations (arthralgia, myalgia), variable with fluctuations in the IS affection were observed in both groups (S1, S2). Analysis of group S1 showed a high number of periarthritic attacks (9 of 20 cases), and a significantly higher incidence of tendinous calcifications (p less than 0.03) and of multiple tendinous calcification disease (MCTM) (p less than 0.05) in relation to 20 matched controls. This combined affection MCTM-IS has not been reported previously. Calcification could be due to glucocorticoid deficiency, the only common factor for all cases, and the frequent calcification of ear pinna (greater than 30% of cases in the 2 groups) could be related to the same deficiency. Finally, reported in the 81 case-reports were 18 episodes of hypercalcemia, emphasizing the unrecognized frequency of this disturbance whose determining role is unclear.

Adrenal Insufficiency↗
PubMed1985

[Calcium oxalate microcrystalline arthropathy in primary oxalosis].

This paper dealt with the case of a 53 years old man, affected by a chronic renal failure as the initial symptom of a primary oxalosis and treated by hemodialysis three years ago. Two years after the onset of renal failure, the left knee was painful and swollen but no cartilage or bone joint lesion was observed. Presence of intra synovial calcium oxalate crystals suggests that this arthropathy may be related to the primary oxalosis. However the role of other calcium salts under identification evidenced by synovial electron microscopy (apatite ? pyrophosphate ?) is discussed.

Calcium Oxalate↗
PubMed1985

[Value of the measurement of intra-articular lactates. Contribution to the diagnosis of septic arthritis. Interpretation of 370 evaluations].

This retrospective study interprets the results of 370 evaluations of the lactate level of joint fluid. 5 groups were established: joint fluid from cases of mechanical (114) and microcrystalline (67) joint diseases, from inflammatory arthritis (149) and from septic arthritis (40). There was a significant difference between the lactate level in fluid from septic joints and that in the other groups. However, there was no significant difference between the rheumatoid joint fluid and the septic joint fluid. The increased level of intra-articular lactate can therefore be considered to be an argument in favour of the diagnosis of septic arthritis, but there is a certain rate of false positives (particularly in the case of rheumatoid arthritis) and false negatives, which require a very careful interpretation of the test. In cases of inflammatory arthritis with a cell count of more than 10,000 per mm3, there is a correlation between the white cell count and the lactate level. This relation is not observed in the case of septic arthritis. The authors did not detect any difference in the levels of intra-articular lactate according to the nature of the infecting organism. They studied 4 specimens of joint fluid from gonococcal arthritis and the levels of lactate were similar to those of other types of septic arthritis.

Arthritis↗
PubMed1984

[Monoarthritis symptomatic of adjacent bone tumors. Study of 5 cases].

The authors present 5 cases of monoarthritis which revealed adjacent bone tumours: a bony metastasis, a fibrosarcoma and three bone lymphomas. In three cases, the synovial histology showed lesions of non-specific synovitis without neoplastic invasion. A review of the literature demonstrates the rarity of these mono- or oligo- arthrites adjacent to bone tumours and two types can be distinguished: neoplastic invasion of the synovium or reactive non-specific synovitis without invasion.

Adenocarcinoma↗
PubMed1984

[Osteoarticular manifestations in adrenal insufficiency].

We conducted a prospective study of the rheumatological manifestations in 20 patients with adrenal failure: 15 women and 5 men with a mean age of 56. Osteo-articular pathology was observed in 19 of the 20 cases (95%). The painful manifestations presented as arthralgia, myalgia or episodes of peri-arthritis; they were associated with active phases of the endocrine disease in 9 cases (45%). The radiological features of these patients were compared with those of age and sex matched controls who were hospitalized for other rheumatological conditions. 11 patients had radiologically visible tendinous calcifications (TC); 6 patients had 3 or more TC. The 20 patients had a total of 31 TC, which was significantly different from the controls. A related finding was calcification of the cartilages of the ears in 4 out of 10 patients (40%). Hypercalcaemia was detected in 5 cases (25%), accompanying episodes of decompensation of the adrenal failure. The pathogenesis of the tendinous calcifications is not clear. Mineralocorticoid treatment can not be considered to be a major aetiological factor for CT, calcification of the ears nor the pain, as its use was very constant. Thus, tendinous calcifications, which have rarely been reported to date, could explain a large part of the painful manifestations of adrenal failure.

Adrenal Insufficiency↗
PubMed1983

[Eosinophilic arthritis and general review of the significance of articular eosinophilia].

The authors report two cases of eosinophilic arthritis in allergic patients, which constitute the 9th and 10th reported cases. This condition consists of episodes of mildly painful, mildly incapacitating monoarthritis, essentially involving the knee, which last 2 to 15 days. These monoarthritis occur in young allergic patients; there are no allergic manifestations during the episode of arthritis and there is apparently no provoking allergen, but examination reveals intense dermographism. Apart from the presence of eosinophil polymorphonuclear cells in the synovial fluid, one can also find Charcot-Leyden crystals (one of the two cases in this study). The histological examination of the synovial membrane in one of these patients revealed an infiltration of eosinophil polymorphs. A raised serum IgE is always found. Including these two cases, the authors have found 11 out of 4277 specimens of joint fluid which show articular eosinophilia. The nine other cases consisted of one haemarthrosis, two post-arthrographic effusions, one filarial arthritis, one psoriatic rheumatism, one Gougerot-Sjögren syndrome and three cases of unclassifiable arthritis. Data from the literature show that articular eosinophilia is a rare phenomenon, that it does not constitute a simple local reflection of a blood hypereosinophilia and that it can consist of the cases found in this study.

Adolescent↗
PubMed1982

[Diphosphonates].

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Diphosphonates↗
PubMed1982

[Lethal forms of connective tissue disease with antiribonucleoprotein antibodies (author's transl)].

Following Sharp's initial findings, the presence of antiribonucleoprotein antibodies in patients with connective tissue disease has long been considered as a sign of favourable prognosis. However, the long-term follow-up of such patients has revealed an increase in the number of severe or lethal cases. The authors report one lethal case and review 22 other published cases. Attention is drawn to the frequency of forms with onset in childhood and of scleroderma-like forms. Most deaths are due to pulmonary lesions, but the heart and kidneys may also be involved. Histological lesions of visceral vasculitis are extremely common.

Adolescent↗
PubMed1982

[Evolution of connective tissue diseases with anti-ribonucleoprotein antibodies (in 28 patients) (author's transl)].

Follow-up of 28 patients with connective tissue diseases with anti-RNP antibodies revealed that the disease had followed a benign course in 19 cases and a more severe course (including one fatal outcome) in 9 cases. Severe symptoms were mainly renal, neurological, psychic, and articular in nature. The association of anti-DNA antibodies and or low blood complement levels was confirmed as being of poor prognostic significance. Correlating the clinical picture with the severity of the cases demonstrated one case of the severe form in 8 minor connective tissue diseases (arthralgia, Raynaud's syndrome, swollen fingers), three severe forms (including one death) in 9 cases of mixed diseases, and 5 severe forms in the 11 patients with isolated connective tissue disease. Minor connective tissue syndromes retain an overall favourable prognosis, but they may become severe. The poor prognosis of the juvenile forms and those related to scleroderma also has to be emphasised.

Adolescent↗