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Biomedical subjects

C L MALHOTRA

Publications and source records attributed to C L MALHOTRA.

At least 19 recordsLinked to original sources
PubMed1963

THE EFFECT OF INTRA(CEREBRO)VENTRICULAR RESERPINE ON THE ACETYLCHOLINE CONTENT OF THE HEART, ILEUM AND HYPOTHALAMUS OF THE DOG.

The effect of injection of reserpine into the cerebral ventricles on the acetylcholine contents of the sino-atrial node, ileum and hypothalamus of the dog was studied in ten dogs. Another group of five dogs served as a control. The effect of intravenous administration of reserpine, in the same dose as given intracerebroventricularly, was also studied on the acetylcholine content of these tissues in five dogs. General sedation, bradycardia, miosis, salivation, emesis and purgation were looked for. Tissues were removed 1 hr after administration of reserpine for estimation of acetylcholine content, which was increased in all the tissues studied. The increase in the peripheral tissues was greater than in the hypothalamus. The increase in the acetylcholine content was not quantitatively related to the other effects of reserpine. The increase in the acetylcholine content of the sino-atrial node and the ileum and also the peripheral effects observed on intracerebroventricular administration of reserpine can be attributed to its central action. With the same dose of reserpine given intravenously the acetylcholine content of the sino-atrial node was significantly increased, while that of the hypothalamus and ileum was not.

Acetylcholine↗
PubMed1962

Effect of reserpine on the acetylcholine content of the heart, the ileum and the hypothalamus of the dog.

The effect of intravenous administration of reserpine in 10 dogs was studied on the acetylcholine content of the sino-atrial node, the right auricle and the right ventricle of the heart, the ileum and the hypothalamus of dog. The general sedation, the bradycardia, and the purgative effects of reserpine were also noted. Tissues were removed for estimation of acetylcholine when bradycardia was maximal. Reserpine increased the acetylcholine content of all the tissues studied. The increase in the peripheral tissues was greater than in the hypothalamus. The bradycardia and the purgative effects of reserpine may be related to the increase of the acetylcholine content of the sino-atrial node and the ileum.

Acetylcholine↗
PubMed1962

Effect of chlorpromazine and reserpine on the catechol amine content of different areas of the central nervous system of the dog.

The effects of chlorpromazine and reserpine on the noradrenaline and adrenaline contents of the frontal cortex, the hypothalamus, the hippocampus and the midbrain were studied in the dog. In control dogs, the catechol amine concentrations were highest in the hypothalamus and lowest in the frontal cortex and the hippocampus. Noradrenaline contents were about seven to nine times as high as those of adrenaline in all the areas. Small doses of chlorpromazine raised the catechol amines in all the areas, the rise being maximum with 5 mg/kg. With increase in the dose of chlorpromazine there was a gradual reversal of the effect and, with 25 mg/kg, there was diminution of noradrenaline content in all the areas except in the hypothalamus. In general, chlorpromazine produced a greater rise in adrenaline than it did of noradrenaline content, and the increase of both amines was very high in the midbrain and the hippocampus compared with the other areas. Reserpine, however, depleted the catechol amine contents of all areas. The depletion was greatest for noradrenaline, an effect quite marked in the midbrain and the frontal cortex. It was concluded that the actions of these two tranquillizers on the catechol amines of dog brain differed both as to site and mechanism.

Animals↗