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C L MALHOTRA

Publications and source records attributed to C L MALHOTRA.

25 records · Page 2Linked to original sources
PubMed1959

The effect of reserpine on the acetylcholine content of different areas of the central nervous system of the dog.

The acetylcholine content of the frontal and temporal lobes, hippocampus, hypothalamus, cerebellum and spinal cord was estimated in 18 dogs 3 hr. after the intravenous administration of reserpine. Another group of 7 dogs served as control. After reserpine (0.5 mg./kg. body weight) there was an increase of acetylcholine in all the areas under study except in the hippocampus. The increase was specially marked in the hypothalamus. In the hippocampus, however, reserpine caused a significant decrease of acetylcholine.

Acetylcholine↗
PubMed1957

Effects of reserpine on blood-pressure responses evoked from the hypothalamus.

Different areas of the hypothalamus were stimulated by a stereotaxic technique before and after reserpine in unanaesthetized cats. Reserpine in a dose of 1 mg./kg. body weight increased the threshold of stimulation of hypothalamic areas in cats giving an initial pressor response. It decreased the threshold of stimulation of areas of the hypothalamus in animals giving an initial depressor response. Reserpine thus appeared to affect the hypothalamus directly in two ways. It depressed the sympathetic centres in the diencephalon and facilitated the parasympathetic ones.

Animals↗