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Biomedical subjects

C L Parsons

Publications and source records attributed to C L Parsons.

119 records · Page 7Linked to original sources
PubMed1977

Role of surface mucin in primary antibacterial defense of bladder.

Histochemical staining of bladder tissue has demonstrated a discrete layer of mucopolysaccharide (mucin) at the surface of rabbit and human bladders. This mucin is disrupted by acid treatment and is probably resynthesized by the transitional cells in less than twenty-four hours and replaced by forty-eight hours. Physiologic data indicate that bladder mucose can resist bacterial attachment, a function that is also disrupted by acid and recovers in less than twenty-four hours. These findings suggest that the surface mucopolysaccharide inhibits bacterial binding and may be the primary antibacterial defense of the urinary tract.

Adsorption↗
PubMed1976

Bladder defense mechanism.

In order for micro-organisms to infect the urinary tract they must adhere to the vesical mucosa so that they remain after voiding. Experiments in our laboratory demonstrated that the bladder has a self-protective mechanism capable of preventing bacterial adherence to the surface. Histochemical staining demonstrated that this substance is a mucopolysaccharide. Treatment of the mucosa with acid disrupted the protective layer and resulted in a 20 to 100-fold increase in bacterial adherence. Within 24 hours this layer reappeared and binding was again reduced to normal. This phenomenon was not related to microbial species or metabolic activity.

Adhesiveness↗
PubMed1975

The primary antibacterial defense mechanism of the bladder.

We have developed a model in rabbits for quantitatively determining the attachment of microbial organisms to the vesical mucosa. Our data suggest that the bladder has a primary antibacterial defense mechanism that serves to interrupt microbial attachment. This mechanism seems to be secretory, since after destruction with acid, the resistance to microbial binding returns in less than 24 hr.

Animals↗
PubMedDate not supplied

Noninvasive positive-pressure ventilation: averting intubation of the heart failure patient.

Mechanically ventilating patients with heart failure who have respiratory distress can increase hospital costs, complications, and mortality. A few studies have evaluated the use of noninvasive positive-pressure ventilation (NPPV) as an alternative treatment for these patients. This article describes NPPV and reviews its use in managing an acute exacerbation of heart failure.

Critical Illness↗