PubMed Health⌕ Search

Biomedical subjects

C Lakshmanan

Publications and source records attributed to C Lakshmanan.

4 recordsLinked to original sources

Chronic muscle wasting in alcoholics--a histochemical and biochemical study.

A comparative histochemical and biochemical study of the anterior tibial muscle of 10 alcoholics suggests that neuropathy could be the cause of chronic muscle weakness and wasting. Myopathic changes did not predominate in the findings. It is concluded that the proximal muscle atrophy could also be attributed to neurogenic damage. Histochemical reactions in muscle specimens show a selective type 2 atrophy and a slight increase in the mean diameter of type 1 fibres. Biochemical investigations reveal that the activities of a number of enzymes representative of energy supplying pathways--the glycogenolysis and glycolysis--as well as acid phosphatase activity in the muscle is lowered. Oxidative enzymes are of similar activity in the alcoholics and the control group. The glycolytic enzyme activity is particularly important, being the most sensitive indicators of the onset, intensity, and course of neurogenic damage.

Adult↗

One stage surgical procedures for bilateral urinary tract lesions.

In a selected group of bilateral urinary tract lesions of varied benign etiologies, single stage corrective surgical procedures were performed in 24 patients. The operations included lithotomies, pyeloplasties, ureteric reimplantations, ureterolysis, nephrectomies, urethral valve fulgurations and repair of vescicovaginal fistulae in various combinations. This procedure has many obvious advantages. The patient will be hospitalized only once and operated upon on both sides in one sitting, thus avoiding multiple anesthesias with their attendant risks. Both kidneys are given equal opportunity to recover simultaneously in obstructive lesions. The overall cost of treatment can be reduced considerably. There were two postoperative deaths with no significant morbidity in the series.

Adolescent↗