Biomedical subjects
Publications and source records attributed to C Lindström.
A patient who for five years had obstinate unilateral facial pain, difficult to interpret, was found to have an expanding process in the left retromaxillary space. Histological examination of a biopsy specimen revealed chondromyxoid fibroma. This tumour is rarely seen in the bones of the face and has never before been described in this area. The clinical and histological findings are described and discussed.
Colon and small-bowel tumors were induced in WF rats by treatment with one of three chemical carcinogens. Tumor occurrence and growth were monitored by multiple double-contrast examinations. Roentgenologic diagnoses and histologic examination of tumors were verified at tumor resection or autopsy. Serial serum samples from each of 11 rats were tested in microcytotoxicity assays for their ability to block the cytotoxicity of lymph node cells from rats with isografts of colon carcinoma NG-W1 against NG-W1 target cells. Sera from all tumor-bearing rats demonstrated specific blocking activity. With two exceptions, serum blocking activity preceded roentgenologic evidence of tumor. Sera of the 2 exceptional rats lacked blocking 2 and 8 weeks before tumor detection, respectively. The sera of only one animal specifically inhibited lymphocyte cytotoxicity despite consistently negative double-contrast examinations. At autopsy this rat was found to have an adenocarcinoma of the distal rectum, impossible to visualize by the roentgenologic technique used. In serum samples obtained from animals after successful tumor excision and with no radiologic evidence of recurrence, blocking activity could no longer be demonstrated. Rats that had received carcinogen but developed no tumor and had no abnormalities on double-contrast examination demonstrated no serum blocking activity.
A prospective epidemiological study of Crohn's disease in Malmö, Sweden, was carried out during the years 1958 to 1973. The mean annual incidence rate for the disease was 4.8 per 10(5) inhabitants at risk. The recorded incidence increased from 3.5 per 10(5) inhabitants during the initial 8-year period, to 6.0 per 10(5) inhabitants during the last 8 years of the study. The maximum annual incidence rate, 8.3 per 10(5) inhabitants in 1971, is the highest hitherto on record. A prevalence rate of 75.2 per 10(5) inhabitants on December 31, 1973 was recorded. The death rate was low: 0.15 per 10(5) inhabitants per year. The alidity of the observed high incidence rates and the rising secular trends are discussed.
All benign polyps in a 10-year series of 960 patients with colorectal carcinoma from a defined population were analysed. All cases where histological specimens of the polyps were available were reclassified according to morphological type and grade of differentiation. The findings lend support to the assumption of a relationship between benign epithelial neoplasms and adenocarcinoma of the colon and rectum.
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A case is described of non-necrotizing, epithelioid cell granulomatous synovitis of the ankle of a 22-year-old man with Crohn's disease. It appears to be the first published example of granulomatous arthritis in association with Crohn's disease.
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Vascular changes were seen in specimens with lesions of Crohn's disease as well as in ulcerative colitis. In Crohn's disease, the vasculature in the bowel wall was rearranged secondary to thickening of the intestinal coats. An anatomical relationship was often found between the ulcers and the point where arteries break through the muscularis propria. The vasculature was markedly increased in areas with deep ulcers and transmural inflammation, but in areas with only small ulcers and mild inflammatory reaction vascular changes were barely discernible or absent. Occlusive vascular changes were uncommon and not visible in the radiographs. In active ulcerative colitis hypervascularity was more marked than in Crohn's disease, but was confined to the mucosa and adjacent parts of the submucosa. In ;burnt-out' atrophy vascularity was not increased and only minor changes in the submucosal arteries were observed. The observations did not suggest that the vascular alterations are of primary importance for the formation of lesions in either disease.
Crohn's disease confined to the appendix is a rare entity, less than 50 cases having been reported. The present study reports on another 12 cases representing 6 per cent of all 194 patients operated upon for Crohn's disease in a total, unselected series. The indications for surgery were appendicitis in eight patients, appendiceal abscess in two, suspected pyosalpinx in one, and an ovarian cyst in one. The appendices were in all cases strikingly enlarged. Giant-cell granulomas, without microabscesses were detected in all but one patient. Two patients had early septic postoperative complications. Fistulization from the cecum did not occur. The median observation time after operation was 13.8 years. Since none of the patients had further manifestations of the disease, it is concluded that patients with Crohn's disease confined to the appendix have a favorable prognosis.
beta-Microseminoprotein is a 10-kDa disulphide-rich protein with unknown function which is present in the mucus of the airways, gastrointestinal tract and urogenital tract. In this paper, an investigation of the distribution of beta-microseminoprotein in the human stomach is reported. Immunohistochemistry and in situ hybridization were used. beta-Microseminoprotein was found to be localized mainly in the antrum part of the stomach and in two types of cells. Cells of the most abundant type (designated M-cells) were the neutral mucin-containing cells in the bottom part of the gastric glands and the surface epithelium. Virtually all these cells contained both beta-microseminoprotein mRNA and protein product. Cells of the second type (designated E-cells) were found in a zone one-third up from the bottom of the gastric glands, where gastric endocrine cells are located. The E-cells were fewer than the M-cells and usually solitary. They seemed to have a high concentration of protein compared with their low mRNA level. The majority of the E-cells contained chromogranin A and gastrin. The observations made have implications for the understanding of the differentiation of the mucosal cells in the antrum of the stomach and form a basis for future studies of beta-microseminoprotein in gastric disease.
The radioprotective effect of vasopressin-induced intestinal ischemia was investigated in pigs. A bolus injection in the cranial mesenteric artery, of a vasopressin solution, 0.05 IU/kg body weight, was followed by irradiation of the small intestine with 6 MV roentgen rays. Three different fraction schedules were used. Weight changes in the animals and the histologic appearance of their intestines were recorded two weeks after irradiation and compared with the findings in untreated animals. Intra-arterial vasopressin was very effective in protecting the intestine. Vasopressin treatment given before 2 fractions with relatively high radiation doses in a 6-fraction regimen was so effective that it may form the basis of a treatment model applicable in man.
A case of extramammary, perianal Paget's disease with underlying rectal carcinoma is presented. The importance of awareness of the condition is stressed and the diagnosis and treatment are commented upon.
The localization of the upper esophageal sphincter is partly controversial. The aim of the present study was to elucidate whether or not the sphincter area could be allocated within an area inferior to and separate from the cricopharyngeal muscle. Cineradiography of the pharyngo-esophageal segment in 252 dysphagial patients disclosed a posterior impression in 55 (22%). There were no signs of a circular impression or other indications of a sphincter localized inferior to the circopharyngeus as revealed on these cinefilms. Macro- and microscopic examination of 16 autopsy specimens revealed the level of the upper esophageal sphincter to be localized within the cricopharyngeal muscle. There was no indication of any sphincter inferior to the cricopharyngeus in the cervical esophagus.