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Biomedical subjects

C M Fenoglio

Publications and source records attributed to C M Fenoglio.

At least 55 records · Page 3Linked to original sources
PubMed1981

The simultaneous expression of human chorionic gonadotropin and carcinoembryonic antigen in the female genital tract. Localization by immunocytochemistry.

Tissue from 180 gynecologic disorders were studied for the simultaneous expression of HCG and CEA, utilizing the immunoperoxidase technique. Of the total population, 0.5% expressed both antigens, 8.8% expressed only hCG, and 5.5% expressed only CEA; 85% expressed neither. The greatest variability of marker expression was among the ovarian and endometrial neoplasms.

Adenocarcinoma↗
PubMed1981

Adenoacanthosis of endometrium: a clinicopathologic study in premenopausal women.

Adenoacanthosis of the endometrium is a disorder characterized by glandular hyperplasia with squamous metaplasia. A clinicopathologic study was done of 10 cases, the majority of which were referred for consultation as atypical hyperplasia of adenoacanthoma. All of the patients were premenopausal and ranged in age from 19 to 45 years: they presented with abnormal bleeding or infertility. In four cases the adjacent endometrium was normal cycling endometrium; two were associated with chronic endometritis, and two were present within endometrial polyps. Three patients responded conservative therapy; in two others, hysterectomy disclosed no residual lesion. Although adenoacanthosis has certain morphologic features mimicking adenoacanthoma, it can be distinguished from this lesion by its growth pattern and cytologic features. Whether adenoacanthosis is a cancer precursor is unknown, but the potential reversibility of the lesion warrants conservative therapy, particularly in women of childbearing age.

Adenocarcinoma↗
PubMed1981

Risks of cervical intraepithelial neoplasia among DES-exposed women.

The increased occurrence of cervical intraepithelial neoplasia (CIN) in women with in utero exposure to diethylstilbestrol (DES) is described. Among 335 self-referred women exposed to DES, 14.9% (50) had a least 1 cytologic smear interpreted as CIN, and 16.2% (54) had at least 1 biopsy interpreted as CIN. Excluding those with grade 1 CIN, 8.7% (29) had at least grade 2 CIN on biopsy and 4.2% (14) had biopsies interpreted as grade 3 CIN. No invasive lesions were detected. Because the problem of differentiating true intraepithelial neoplasia from morphologically indistinguishable but benign lesions in DES-exposed women remains unresolved, the authors believe a conservative approach to treatment is still indicated. This study supports the recommendation that DES-exposed women merit continued thorough gynecologic evaluation, including regular cytologic evaluation and colposcopy, with biopsies as indicated.

Adult↗
PubMed1981

Carcinoembryonic antigen in gynecologic patients. II. Immunohistological expression.

Certain tumors of the female genital tract have a very probability of expressing CEA activity. These include endocervical carcinomas and ovarian Brenner tumors. This information may be helpful in allowing one to distinguish among several diagnostic possibilities on a given biopsy. CEA detection apparently fails to distinguish between endometrial hyperplasias versus endometrial carcinomas. Gonadal stromal tumors of the ovary are generally negative, whereas the common epithelial tumors (depending on the histological type) have a reasonable probability of having detectable antigen. Since plasma CEA levels have had a demonstrated usefulness in following patients who were known to have elevated CEA levels prior to the removal of their primary tumor in the endometrium, ovary, and cervix, it is valuable to have an estimate of probability that a tumor will express CEA in evaluating the results of plasma radioimmunoassays for this antigen.

Adenocarcinoma↗
PubMed1980

Histogenesis of Brenner tumors, I: histology and ultrastructure.

The histology of 36 benign and four proliferative Brenner tumors is reviewed, and the ultrastructural features of benign Brenner tumors are described. Evidence is presented for the origin of these tumors from celomic inclusion cysts through transitional metaplasia of the cyst lining and progressive growth of branching cords of transitional epithelium. Ovarian lesions associated with the Brenner tumor are described, particularly those containing mucinous epithelia, and their significance is discussed.

Adult↗
PubMed1980

Histogenesis of Brenner tumors, II: histochemistry and CEA.

The histochemical characteristics of 21 benign Brenner tumors were studied. The mucins associated with these tumors are of transitional cell origin and do not represent a secondary metaplasia of transitional to intestinal-type epithelium. The goblet and ciliated columnar cells associated with the proliferative Brenner tumor are thought to represent a parallel mucinous metaplasia from celomic epithelium. Thirteen of the 16 benign Brenner tumors and the one proliferative Brenner tumor were found to contain carcinoembyronic antigen (CEA), indicating an additional antigenic similarity to transitional epithelium.

Antigens, Neoplasm↗
PubMed1980

The immunoperoxidase technique a review of its application to diseases of the female genital tract.

Immunoperoxidase techniques (IMPO) have gained widespread acceptance by virtue of their potential use in the fields of pathologic diagnosis and research. The increasing availability of specific antisera have enabled investigators to localize a variety of hormones, enzymes, oncofetal antigens, viral antigens, micro-organisms, and other biologic markers. IMPO techniques have been employed extensively in the investigation of gynecologic diseases and have been useful, not only as special stains identifying specific neoplasms, but also for providing addtional insight into the biologic behavior of gynecologic neoplasms, and the functional and pathogaenetic nature of germ cell tumors, gonadal stromal neoplasms, and peptide hormone-producing neoplasms. Recent studies using IMPO to localize hormone receptors and viral antigens promise the continued use of this technique as a research tool to complement the more complex methods currently in use.

Antigens, Neoplasm↗
PubMed1980

Antigens, enzymes and hormones. Their roles as tumor markers in gynecologic neoplasia.

The membranes of neoplastic cells contain a variety of glycoproteins which may function as antigens, hormones, or as key enzymes in the modification of the cell surface. The structure of the normal cell membrane, and the glycoproteins which may present within it, are briefly surveyed. Specific emphasis is placed on antigenic changes related to tumors found within the female genital tract. In addition, enzyme changes and mechanisms for the release of these proteins from the cell surfaces are discussed. Methods for detecting glycoprotein (antigenic) changes are briefly surveyed.

Antigens, Neoplasm↗
PubMed1978

Malignant mixed tumor of the vagina probably arising in mesonephric rests.

An exceedingly rare tumor arising in the upper lateral vagina is described histologically, histochemically, and ultrastructurally. It is compared to the lesion reported by Okagaki et al. which is considered to represent the same type of tumor. Comparison with synovial sarcomas indicates that the lesion is similar, but the reasons why it should not be so classified are discussed. Evidence is presented for the origin of these tumors in mesonephric rests (Gartner's duct).

Adult↗
PubMed1978

Evaluation of polymer flock and metal alloy intra-tubal device in pigtail monkeys.

Two intratubal devices, one covered with a flock made from ethylene vinyl acetate and the other constructed of titanium-aluminum-vanadium alloy with an etched surface were evaluated after being placed in the Fallopian tubes of pigtail monkeys. In some instances, the devices were medicated with 10% silver nitrate or 50% quinacrine hydrochloride. The microflock device anchored in the tube mechanically, but there is no evidence that either the polymeric or metal alloy device formed an actual attachment with Fallopian tube epithelium. It is suggested that a mechanical design approach to ITDs might be more productive than one which assumes a tissue-device bond.

Alloys↗