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C M Fenoglio

Publications and source records attributed to C M Fenoglio.

At least 73 records · Page 4Linked to original sources
PubMed1977

Clear cell carcinoma of cervix and vagina in progeny of women who received diethylstilbestrol: three cases with scanning and transmission electron microscopy.

Three cases of clear cell carcinoma of the cervix and vagina in progeny of women administered diethylstilbestrol (DES) were studied ultrastructurally. The patients were young and had a positive history of maternal ingestion of DES during pregnancy. Similar ultrastructural features were observed in all cases. The neoplastic cells were arranged in solid nests or glands. Ultrastructural findings in these cases were similar to those of previously reported clear cell carcinomas of the ovary and endometrium, which seems to indicate a common Müllerian origin11, 16 as opposed to a mesonephric origin. 10 A transition between vaginal adenosis and the neoplasm was not observed.

Adenocarcinoma↗
PubMed1977

Immunoperoxidase: a sensitive immunohistochemical technique as a "special stain" in the diagnostic pathology laboratory.

The present communication is a brief review of the origins, theory, and applications of a relatively new immunohistochemical technique that can be performed on routinely fixed, paraffin embedded tissues in which visualization by bright field light microscopy is feasible and which thus can be readily adapted to routine diagnostic work. The chief concern of this presentation is the practical diagnostic application of the immunoperoxidase technique, a method whose reputation as a sensitive investigative tool is well established.

Carcinoembryonic Antigen↗
PubMed1977

Carcinoembryonic antigen: immunohistologic identification in invasive and intraepithelial carcinomas of the lung.

A total of 58 pulmonary lesions from 48 patients were examined for carcinoembryonic antigen (CEA). The three-layer immunoperoxidase procedure for antigen detection was used with a monospecific anti-CEA antiserum. The control serum was the same antiserum with its specificity removed by affinity chromatography. Normal goat serum was also used as a control. Carcinoembryonic antigen was present in the majority of pulmonary adenocarcinomas and generally absent in the squamous cancers. The major exception was in the well-differentiated squamous lesions where CEA was occasionally found in the keratinizing areas. Of special interest was the finding of CEA in all areas of intraepithelial squamous neoplasia studied.

Adenocarcinoma↗
PubMed1977

The lack of specificity of the sheep erythrocyte-T lymphocyte rosetting phenomenon.

One subpopulation of lymphocytes, thymus-derived (T) cells, is identified by its characteristic ability to form spontaneous rosettes with sheep erythrocytes (SRBC). However, the mechanism by which the rosettes form remains unknown. To gain more insight into the specificity of this phenomenon, the ability of SRBC to rosette with cells other thah lymphocytes was studied. All of the cell types utilized in this study (L cells, monkey liver cells, HeLa cells, and human liver, bladder, lung, parathyroid, and dermal fibroblasts), except neoplastic B lymphocytes, rosetted with SRBC. Viability was not a factor in the rosette formation. These findings suggest that the process of T lymphocyte-SRBC rosette formation is not due to a T cell-specific membrane receptor or antigen but may be due to a widely distributed basic substructure of the cell membrane.

Animals↗
PubMed1976

Scanning and transmission electron microscopic studies of vaginal adenosis and the cervical transformation zone in progeny exposed in utero to diethylstilbestrol.

Much attention has recently been focused on vaginal adenosis and other cervical and vaginal alterations occurring in female offspring exposed to diethylstilbestrol (DES) in utero. These alterations consist of heterotopic glandular epithelium in the vagina, a characteristic cervical transformation zone, and the frequent presence of a cervical collar, or hood. It is believed that these changes occur during embryonic differentiation of the lower genital tract following failure of squamous epithelium to migrate in a cephalad direction to replace columnar epithelium which normally lines the vagina and ectocervix. A number of cases clear-cell carcinoma have occurred in DES-exposed girls who also had adenosis. In an attempt to characterize the cellular populations of these areas of adenosis, we have made an ultrastructural study which is herein reported.

Cervix Uteri↗
PubMed1976

Mucinous tumors of the ovary. II. Ultrastructural features of mucinous cystadenocarcinomas.

On the basis of light microscopic and scanning and transmission ultrastructural observations, ovarian mucinous tumors of borderline malignancy contain two types of mucinous epithelium--an endocervical type and an intestinal type. The fully malignant tumors were composed solely of intestinal-type epithelium. These findings may have prognostic and therapeutic significance.

Cystadenoma↗
PubMed1976

I. Observations on the adenoma as precursor to ordinary large bowel carcinoma.

The very common hyperplastic polyp is not a neoplasm and is unrelated to either adenoma or carcinoma. Adenomas, which are only one-tenth as common, are true neoplasms. Depending on size, and probably related to a sessile mode of growth, in adenomas one may readily observe intramucosal carcinoma and/or early invasive cancer. Although microscopic examination has been performed on many thousands of minute mucosal lesions (e.g., 5 mm or less), "early" cancer, defined cancer, defined as intramucosal carcinoma with or without microinvasion, does not seem to occur unassociated with adenoma. The apparent nonexistence of small foci of intramucosal carcinoma, with or without microinvasion, in normal mucosa, and their frequency in adenomas, are two fundamental pathologic facts. They seem to disprove the proposition that cancer calls ordinarily arise de novo from the normal cells of the crypt of Lieberkühn without the interposition of a stage in the neoplastic process that we recognize as adenoma.

Adenoma↗
PubMed1976

Scanning electron microscopy of surface features of hamster embryo cells transformed in vitro by X-irradiation.

Scanning electron microscope studies were carried out on Syrian hamster embryo cells transformed in vitro by X-irradiation (300 rads) (X-ray transformed) and on normal nonirradiated and irradiated nontransformed controls. Transformed cells appeared in scanning electron microscopy as pleomorphic, thick cells piling up over each other and exhibiting extensive surface features consisting of microvilli, blebs, and ruffles. These surface structures were seen on single as well as on densely cultured transformed cells during both interphase and mitosis. The complex surface was observed shortly after transformation (on cells of a 20-day-old clone) and seems a permanent feature of the X-ray-transformed cells (present after 8 years in culture). All controls appeared by scanning electron microscopy as regular, flat, and smooth cells which grew in high-density cultures to seemingly contact-inhibited monolayers. During mitosis the normal cells (control, nontransformed) displayed surface excrescences similar to those of the transformed cells making the mitotic normal cells indistinguishable from transformed cells. The complex surface features in the normal cells were temporary and reversed back to characteristic smoothness upon reentrance into interphase.

Agglutination↗
PubMed1975

Mucinous tumors of the ovary. Ultrastructural studies of mucinous cystadenomas with histogenetic considerations.

On the basis of light microscopic and scanning and transmission ultrastructural observations, we have classified benign mucinous ovarian neoplasms into two types: a pure endocervical type and a mixed intestinal endocervical type. We have also reviewed the literature pertinent to the histogenetic origin of the ovarian mucinous cystoma and found convincing support for a mesodermal, coelomic epithelial, rather than a teratomatous, derivation.

Adult↗