[Peridural anesthesia with opiates. Clinical and neuropharmacologic criteria for the choice of combination].
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Biomedical subjects
Publications and source records attributed to C Mazzi.
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The secretion values of the two seric gonadotropins and of plasmatic testosterone have been estimated in a casuistry of normal males subdivided in groups of 8 to 95 years of age, and of primitive and secondary testicular dyschrinia. In one part of this casuistry, normal and primitive hypogonadics, we have estimated the response to the intravenous administration of Gn-RH. Among the results which have been obtained, it appears that physiologic hypogonadism of the elderly is a primary phenomenum, not hypophyso-dependent. In the hypophysiary stimulus test, the response of gonadotropins in those old men moves away from the response of hypogonadics considered, by a behaviour much more similar to that of normal adults, even if delayed and prolonged. In all the cases, normal and pathologic, the response of testosterone is variable, perhaps owing to the relation with the various factor which have been noted.
The effect of i.v. trazpdone on PRL and GH was studied in normal subjects and in patients with hypophyseal adenoma coupled with amenorrhoea and galactorrhoea or acromegaly. PRL levels were reduced, whereas the behaviour of GH was paradoxical. These results suggest that the dopaminergic and serotoninergic systems take part in regulating the secretion of these two hormones. An interesting comparison was made with their behaviour following the administration of bromoergocryptine in the adenoma series.
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The occurrence of uterine bleeding following administration of Metyrapone in cases of secondary amenorrhoea and oligomenorrhoea led the authors to measure pituitary, gonadal and adrenal hormone levels, before and after the oral administration of this drug in sixteen patients, in an attempt to provide an interpretation of this phenomenon. There were expected changes in plasma ACTH and urinary 17-hydroxycorticosteroids, but no variations were noted in serum FSH and LH, plasma oestradiol and urinary oestrogens; the most important alterations occurred in plasma progesterone and urinary pregnanetriol levels. It is suggested that bleeding occurs because of the changes which are induced in plasma progesterone levels.
The secretion values of the two seric gonadotropins and of plasmatic Testosterone have been estimated in a casuistry of normal males, 114 subjects, subdivided in groups of 8 to 95 years of age. Our investigation allowed to compare hormonal levels in the different ages; in particular, the pattern in senescence appeared greatly interesting. In one part of this casuistry, we have estimated the response to the intravenous administration of Gn-RH. The test showed a positive gonadotropic response in all ages, with some differences between FSH and LH, and induced no significant change in testosterone secretion. Among the results which have been obtained, it appears that physiologic hypogonadism of the elderly is a primary phenomenon, not hypophysodependent.
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