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Biomedical subjects

C Mocanu

Publications and source records attributed to C Mocanu.

At least 19 recordsLinked to original sources
PubMed2001

[Inflammatory ocular diseases associated with oro-dental pathology].

PAPER AIM: It is presented the correlation between the uveitis and the focal dental disease with infection, irritation or allergic pathogenicity. MATERIAL AND METHOD: This study was performed on a set of 54 patients with uveitis and dental diseases patients hospitalized in the Clinic of Ophthalmology of Craiova, during 1998-1999. This correlation was observed in 38-40% of uveitis. There were also mentioned some dental damages associated with uveitis: radicular focal infections, periodontitis under prosthetic works, fights cavities, inclusions dental chronic maxillary osteitis. RESULTS: The correlation uveitis-dental diseases was noticed in 1.2-1.8% of the hospitalized patients, comparing with 3-5% in literature (including the ocular adnexa diseases). CONCLUSIONS: This study shows the reality of the correlations between uveitis and dental diseases. It was relieved the importance of correlation ophthalmologist-stomatologist.

Adult↗
PubMed2001

[Evolution of ocular infection in diabetes mellitus patients].

PAPER AIM: The paper presents the infectious complications at patients with diabetes mellitus, and the evolution of these complications with the type of diabetes and the treatment with orale hypoglycemic agents or insulin. MATERIAL AND METHOD: The survey was fulfilled in the Clinic of Ophthalmology of Craiova and in the Metabolic Diseases clinic, during a period of 10 years. RESULTS: We surveyed 497 hospitalized patients, and we noticed different infectious complications: kerato-endothelitis in 9 cases, herpetic keratitis in 11 cases, anterior uveitis in 16 cases, corneal ulcus in 24 cases, total uveitis in 6 cases. In 17% of the cases, the patients were not previously aware about the diabetes affection. CONCLUSIONS: The very severe infectious complications of the eye in diabetes, determine the doubling of the ocular and general treatment, for normalisation of the blood glucose and a good evolution of the diabetes.

Diabetes Complications↗
PubMed2001

[Efficacy of ophthalmic suspension of Brinzolamide (Azopt) in the primary or combined therapy for patients with hypertensive glaucomas].

UNLABELLED: The primary objective of this prospective study was to evaluate the efficacy of lowering intraocular pressure, safety and tolerability of Brinzolamide 1% ophthalmic suspension as primary or adjunctive therapy in hypertensive glaucomas. MATERIAL AND METHOD: Brinzolamide 1% was administrated in monotherapy or in combination for 26 patients suffering from hypertensive glaucomas. The patients were divided in two groups: group I--included 10 patients (20 eyes) with primary open-angle glaucoma in which suspension Brinzolamide was administrated in monotherapy, and, group II--(16 patients with 30 eyes) with diverse forms of hypertensive glaucomas, that the Brinzolamide was administrated in adjunctive therapy, after the failure of another forms of medication, especially, beta-blockers. Intraocular pressure was assessed at 8, 10 AM, and 6 PM in first day, then daily at 8 AM, 7 days, and finally, weekly, at 8 AM all the period. Dilated fundoscopy, automated perimetry, visual acuity, were performed in addition to hematology, blood chemistry, urinalysis testing and ocular events. RESULTS: The intraocular pressure-lowering observed on treatment was as follows: 3.5 mmHg to 4.8 mmHg (13.5% to 18.2%) in patients which Brinzolamide 1% dosed two times a day, and, 4.2 to 5.2 mmHg (17.8 to 20.9%) after administration Brinzolamide three times a day. The association of Brinzolamide with another therapy induces in an additive ocular hypotensive effect, which was stable in the whole period of the study. The ocular and general tolerance was significantly improved for another hypotensive drugs and another carbonic anhydrase inhibitors topically active. This fact allows a long treatment period.

Adrenergic beta-Antagonists↗
PubMed2001

[Clinical and epidemiological aspects in ocular tuberculosis].

150 new cases of ocular tuberculosis, representing 1% of total tuberculose cases, was diagnosticated during the last 10 years, in both Ophthalmological and Pneumophtisiological Clinics of Craiova. Ocular tuberculosis is the local manifestation of a general latent tuberculosis; the uveal diseases represent 46% of cases of ocular tuberculosis. 51 of 150 cases of ocular tuberculosis was corioretinal forms, which evaluated uni or bilateral, with one and multiple focares; in only one case we constated a coroidian tuberculom form.

Adolescent↗
PubMed2001

[Color Doppler ultrasonography of the orbit in the treatment and evolution of the open angle glaucoma with normalized pressure].

UNLABELLED: The purpose of the paper consists to evaluate the vascular component that it takes part to ethiopatogenie of certain forms of primary open angle glaucomas, as well as to suggest a specific treatment. MATERIAL AND METHOD: 14 patients (28 eyes) with primary open angle glaucomas with average of 64 years were investigated by Color Doppler Imaging. All patients present deteriorations papilo-perimetric or/and visual acuity, in spite of normalized pressure by medical or surgical treatment. RESULTS: The calculus of the velocimetric indices allowed us to measure the vascular resistance index that is increased at 6 patients in ophthalmic circulation, 4 patients in central retinal artery and 2 patients in whole shaft carotid-ophthalmic. We are found a correlation between papilo-perimetric deteriorations and the value of the vascular resistance index, too. Giving vasodilatative drugs that grow the ocular blood flow by improving the microcirculation at the level of the optic nerve's head, such as calcium channel blockers, could benefit effects for this type of patients. CONCLUSIONS: Orbitar Color Doppler Imaging allows to evaluate the vascular lesions that have a negative influence in the evolution of primary open angle glaucomas, and, therefore, suggesting a specific treatment.

Aged↗
PubMed2000

[Chorioretinal lesions in deaf mutes].

The paper reports a study of 216 patients of special deaf-mute schools from Craiova. The exam of them showed us the presence of retinal degenerative lesions in 17 cases (7.8%). There was not a parallelism between deafness' degree and retinal lesions expanse. In point of clinical aspect, the retinal degenerative lesions were Sjögreen retinal lesions in 6 cases, colloidal Amalric-Bessou retinal lesions in 6 cases. In 2 cases lesions had a pseudoinflammatory aspect and another 2 cases were peripheral lesions like "salt and pepper's". Only one case had pigmentary osteoblastic mobilization. Deafness was associated with oligophrenia in 15 cases, with discreet manifestations of eredoataxia Friedreich in 5 cases, with epilepsy in 2 cases and with nanism in another 2 cases. It is necessary a complex oto-neuro-ophthalmological exploration of patients with deaf-muteness.

Adolescent↗
PubMed2000

[The incidence of ocular complications in 10,000 diabetes mellitus patients hospitalized at Dolj County Clinical Hospital].

The paper surveys the statistical results of retrospective analysis for observation sheets of patients having mellitus diabetes, type I and II, hospitalized during the last 10 years at the Ophthalmological Clinic in Craiova. The accent was made on the ocular complications related to the type of mellitus diabetes, the age of its debut, the evolution length, the treatment made, glycemia compensation, which make this affection to be the first cause of cecity at adult age.

Adolescent↗
PubMed1997

[Genetic predisposition in glaucoma].

The comparative study of the genetic factors implication in low-tension and high-tension glaucoma showed the presence of glaucoma familial cases in both form. In 3 cases of low-tension glaucoma the presence of other familial cases of high-tension glaucoma was revealed. The existence of hereditary cases of high-tension glaucoma in families with low-tension glaucoma suggests the existence of some common factors, responsible for producing both affections. On the other hand, the systematic research of the existent glaucomatous deficits at the patients with glaucoma familial cases deserves greater attention.

Disease Susceptibility↗
PubMedDate not supplied

[Periodontal regeneration with enamel derivate proteins (Emdogain)--clinical evaluation].

UNLABELLED: The study was undertaken in order to evaluate the effect of Emdogain as an adjuvant in periodontal surgery in promoting bone level gain, compared to bone levels after surgery. METHOD: The study was realised on 6 patients. who had pair test sites and control sites. Two interproximal sites were selected in each patient at a distance from each other, in the same maxilla, with infra-osseous defects with depth > or = 4 mm and width > or = 2 mm. The patients were followed on a long term period, initially and after 8 and 16 months. RESULTS: The average values of the clinical attachment level were evaluated both in the test sites and in the control group at 8 months and 16 months, The radiographic osseous level continued to recede at the group treated with Emdogain, and in the control group it remained at its initial level. The radiographic gain was ascertained after 16 months. CONCLUSION: This study proves that the topic use of Emdogain as an adjuvant, during periodontal defects surgery, on radicular surfaces, determines a gain in the clinical attachment and an osseous gain observed on X-rays.

Administration, Buccal↗
PubMedDate not supplied

[Comparison on the effects of metronidazole in subgingival application in the treatment of adult periodontitis].

UNLABELLED: Control of subgingival plaque is the key of the treatment of periodontal diseases. The use of subgingival sustained-release antibiotic therapy is advocated for the beneficial effect on anaerobic flora. A single-blind clinical trial was carried out in 13 patients with adult periodontitis to compare the effects of subgingival application of metronidazole dental gel with those of subgingival scaling. METHOD AND MATERIALS: A split mouth design was used so that each patient received all treatments simultaneously. Randomly selected quadrants were treated with applications of 25% metronidazole gel, subgingival scaling, or a combination of scaling and gel application. The remaining quadrant in each patient was left untreated as a control. RESULTS: All three treatments were effective in significantly reducing bleeding on probing over the 14 weeks observation period. No statistically significant differences were found between scaling alone and combined treatment. Scaling and combined treatment were better than metronidazole. Metronidazole produced transient effects, best noted during the first 4 weeks after treatment. No additive effect of metronidazole was noted in the combined treatment. At week 14, only combined treatment sites and scaled showed statistically greater probing depths reduction than control sites. CONCLUSION: For the treatment of mild to moderate adult periodontitis, subgingival scaling alone is as effective as the combination of scaling and antibiotic therapy.

Adult↗
PubMedDate not supplied

[The ocular manifestations in craniopharyngioma].

11-years-old patient, for which the cranial radiograph shows modifications specific to craniopharyngioma, presents diminution of visual acuity at both eyes, psychic retardation and signs of insipidus diabetes. It is emphasized the unusual association between craniopharyngioma and exophthalmos, discordantly appeared on a background of global glandular insufficiency.

Child↗
PubMedDate not supplied

[The lessening of papillary excavation after the hypotonic treatment of the glaucomatous eye].

The possibility of improving the aspect of the glaucomatous excavation under the influence of the postoperative ocular hypotonization is shown on 12 eyes (11 patients) observed during the past 13 years. All patients suffered from very advanced chronic simple glaucoma--8 had a C/D 0.9 (postoperatively 0.6 in 3 eyes, 0.4 in 4 eyes and 0.1 in 1 eye), 3 a C/D 0.8 (postoperatively 0.4 in 1 eye and 0.2 in 2 eyes) and 1 a C/D 0.7 (which diminished postoperatively to 0.4). Of the 12 eyes, only one showed an improvement of the visual field, 5 a lowering of the visual acuity (progression of the cataract) and 3 a decrease of the visual field after a new increase of the intraocular pressure.

Aged↗
PubMedDate not supplied

[Glaucomatous optic neuropathy].

The pathogenic mechanisms of the glaucomatous optical neuropathy in the open angle glaucoma are incompletely elucidated, being a subject of current research. The alteration of the optic nerve in glaucoma reveals either an ischaemic cause, either a mechanical compression; other theories imply the alteration of the axo-plasmic flow, or freeing of some X-hystothonical substances, or the initial alteration of the lamina criblata. Modern examination of the optical disk in glaucoma, using computer-aided planimetry methods and papillary circulation studying by Doppler laser velocimetry, fluorescein angiography a.s.o., is not part of the current practice of examination. Yet, it is extensively used in scientific research, for revealing of new physiopathological aspects.

Glaucoma, Open-Angle↗
PubMedDate not supplied

[Giant-cell retinal dysplasia in microphthalmos].

Six-year-old girl presents unilateral moderate microphthalmos. After enucleation ocular histopathological exam shows multiple ocular structures anomalies at both anterior and posterior poles; the most important anomalies were localised at the level of retina, vitreous, and iridocorneal angle, and they were represented by retinal dysplasia with giant cells, persistence of the primitive vitreous, congenital cataract, Rieger syndrome.

Abnormalities, Multiple↗