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Biomedical subjects

C Mogensen

Publications and source records attributed to C Mogensen.

At least 19 recordsLinked to original sources
PubMed1991

Microheterogeneity and interspecific variability of the nuclear sperm proteins from Mytilus.

We have used acetic acid-urea-triton (AUT) gel electrophoresis and ionic exchange chromatography in order to analyze the interspecific variability and microheterogeneity pattern of the protamine-like (PL) proteins of the sperm of 4 different species of the bivalve mollusc, Mytilus. We have found that based upon these 2 criteria, it is possible to unambiguously distinguish each species from the rest. We have thus been able to corroborate the identity of M. trossulus. We have also analyzed the amino acid composition of some of the PL components for each different species. In the case of the PL-II* fraction, we have analyzed the composition of its major protein subcomponents.

Amino Acids↗
PubMed1985

A leiomyosarcoma of the hypopharynx.

A fourth case of leiomyosarcoma of the hypopharynx is reported. The histopathological diagnosis and treatment are discussed. Surgery is still the treatment of choice and, in combination with chemotherapy (especially Methotrexate) and radiotherapy, the recurrence rate can be reduced. However, randomized studies are required.

Combined Modality Therapy↗
PubMed1982

Spontaneous course and frequency of secretory otitis in 4-year-old children.

Five repetitive tympanometric screenings performed during one year in 288 randomized, otherwise healthy 4-year-old children showed that 50% of ears changed tympanogram type between each trial. The total frequency of secretory otitis was high; thus, 32% of all 576 ears had type B at least once and 73% had either type B or C2, indicating a middle ear pressure of -200 mm H2O or lower. At three trials during at least six months, 8% had type B and 24% either type B or C2. The spontaneous improvement of secretory otitis was high, and type B improved in 78% to 88% of ears, although in some ears the type again deteriorated. Severe changes of the tympanic membrane were found in 0.5% of ears, and it is therefore advised to postpone surgical treatment of secretory otitis for three to six months.

Acoustic Impedance Tests↗
PubMed1980

Quantitative histologic features of the normal frontal sinus.

The entire mucosa from 30 normal frontal sinuses was removed, stained by the whole mount method, and the density of goblet cells and mucous glands was determined. There was an average of 6,300 goblet cells per square millimeter without statistically significant differences between the various walls. The glands were small and seromucous. In 87% of the sinuses, the gland density was less than 0.2 glands per square millimeter, and the total gland count did not exceed 40. This represents a totally negligible mucus production, which must be derived predominantly from the goblet cells. The density proved significantly higher in the inferior parts of the sinuses. The findings are discussed in relation to other areas of the respiratory tract.

Cell Count↗
PubMed1979

Mucus production in the nasal sinuses.

The density of goblet cells and glands was determined in the maxillary, ethmoidal, frontal, and sphenoidal sinuses. Goblet cells showed the highest density in the maxillary sinuses. 9700 per mm2, while in the other sinuses their density was approximately the same, from 5 900 to 6 500 cell per mm2. The density of glands was highest in the ethmoids, 0.5 gland/mm2, then in the maxillary sinuses, viz. 0.2 gland/mm2, while in the frontal and sphenoidal sinuses it was very low, 0.08 and 0.06 gland/mm2 respectively.

Cell Count↗
PubMed1979

Experimental surgery of the nose, anteroposterior changes of the mucosa on altering the air-flow.

In 20 rabbits one nostril was surgically closed and the mucous membrane studied 4--90 days after the operation. The density of goblet cells was determined anteriorly and posteriorly on whole mounts, epithelial changes on serial sections from 4 different localities on the septum. Anteriorly on the open side damage to the cilia initiated epithelial processes of repair, viz. hyperplasia of basal cells, transformation of these cells into columnar cells, and differentiation into mucous and ciliated cells. On the 16th day the epithelium was again columnar and ciliated. As a consequence of continued trauma new cycles were initiated, but not even after 90 days was there any squamous epithelium. In the middle and posteriorly on the septum no changes were demonstrated, indicating a marked, but gradual decrease in the anteroposterior direction of the influence by the air-flow upon the mucosa. On the closed side there was increased secretory activity and normalization of the epithelium which was changed most anteriorly in normal rabbits.

Animals↗
PubMed1978

Changes of the nasal mucosa in altered airflow illustrated by blind quantitative histology.

In 20 rabbits one nostril was closed surgically for 4, 10, 16, 20, 60 and 90 days, and thereafter the mucous membranes from the open and closed sides of the nose were investigated. Anteriorly on the open side a process of repair started as early as the 4th day after ciliary damage. This process consisted in hyperplasia of basal cells, displacement and gradual desquamation of ciliated cells and goblet cells, differentiation of basal cells into ciliated and goblet cells. On the 16th day the epithelium was again ciliated. As a result of a continued abnormally increased airflow new damage to the cilia occurred and a new cycle was initiated, so that on the 30th and 90th days the epithelium was again ciliated. Even though the epithelium is 'squamous-like' in some phases, there is no question of a transformation into squamous epithelium. On the closed side anteriorly there is increased secretory activity in the epithelium. Posteriorly blind quantitative histology showed no differences between the open and the closed side, or between 'treated' and control material.

Animals↗
PubMed1978

Quantitative histology of the normal ethmoidal sinus.

In 16 patients the mucosa from 32 normal ethmoidal sinuses was removed post mortem and studied by whole-mount methods. In the anterior ethmoidal cells, there was a median density of 0.5 gland/mm2, in the posterior cells 0.13 gland/mm2. The distribution of the glands was irregular, with the highest density around the ostia. Individual variations of density were wide, ranging from 0.07 to 0.81 gland/mm2. The median density of goblet cells was the same in the anterior and posterior ethmoidal cells, about 6,900 cells/mm2. The greater part of the mucous secretion in the ethmoid is produced by the goblet cells.

Cell Count↗
PubMed1978

Quantitative histology of the normal sphenoidal sinus.

From 32 normal sphenoidal sinuses in 16 patients the mucosa was removal at autopsy, stained by the PAS-alcian blue whole mount method, and the density of goblet cells as well as of mucous glands was determined. The median density of goblet cells was 6200 cells per mm2, without statistically significant differences between the walls. The median density of glands was very low, 0.06 gland/mm2, highest in the anterior wall which has 0.1 gland/mm2 and lowest in the posterior wall which has 0.05 gland/mm2. The total gland count was less than 50 in 94% of the sinuses, 51--80 in 4%. The glands were small, tubulo-acinous. Hence, the production of mucus by the glands is entirely negligible in relation to that of the goblet cells.

Cell Count↗
PubMed1977

Mucous glands in nasal polyps.

A total of 102 nasal polyps from 52 patients were stained by the PAS-alcian blue whole-mount method, and mucous glands were studied quantitatively. Glands were found in all polyps but in many of them only a few. The density is very low, considerably lower than in the nasal mucosa. The glands are tubular, of different shape and size, but differ widely from those in the nose and are formed from the surface epithelium after the polyp has attained a certain size. They do not issue from the nasal mucosa. The glands degenerate and distend. Thus, cysts in the polyp are degenerated, mucus-filled glands.

Adolescent↗
PubMed1977

Nasal polyps in cystic fibrosis.

In II polyps from patients with cystic fibrosis of the pancreas, the density, shape, and architecture of mucous glands were studied by the whole-mount method and compared with 102 non-cystic-fibrosis polyps. There were no differences in density which was in most polyps less than 0.5 gland/mm.2. The shape and architecture as well as other histological appearances of the polyp were also alike in both groups of polyps which could not be distinguished. The pathogenesis of nasal polyps in cystic fibrosis is discussed. Apparently, it is the same as that of non-cystic-fibrosis polyps.

Child↗
PubMed1977

Density of goblet cells on normal adult nasal turbinates.

On the basis of 10 middle and 10 inferior turbinates from autopsies on normal adults, a quantitative study of the goblet cells was performed, using the whole-mount method. There was quite some increase in density into the posterior direction, with a generally higher density on the inferior than on the middle turbinate. The results are related to the current of air in the nose.

Age Factors↗
PubMed1977

Density of goblet cells in the normal adult human nasal septum.

On ten adult septal mucous membranes, stained by the PAS-alcian blue whole-mount method, the density of goblet cells was determined in 12 localities distributed on the entire septum. The median density proved to be slightly, but significantly increasing into the anteroposterior direction, there being 4,800 in the anterior and 6,200 cells per mm2 in the posterior quarter of the septum. There was a tendency to higher density in the lower than in the middle and upper thirds. However, these differences were not statistically significant. Interindividual variations in density and variations within different segments of the same septum were relatively pronounced. This goes to show that the assessment of goblet cell density on the basis of sections, so often seen in the literature, can only be taken with the utmost reserve.

Aged↗