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Biomedical subjects

C Mogensen

Publications and source records attributed to C Mogensen.

29 records · Page 2Linked to original sources
PubMed1977

Quantitative histology of the maxillary sinus.

The entire mucosa from 10 normal maxillary sinuses was removed post-mortem and stained by the PAS-alcian blue whole-mount method. The density of goblet cells and of mucous glands was investigated. The median density of goblet cells was 170 cells/field, corresponding to 9,600 cells per mm2, with wide individual variations, but there were no significant differences in density between the various walls. The density of goblet cells was somewhat higher than in the nose. Glands were very scarce and small in the maxillary sinus. Their median density in most walls was 0.15-0.20 gland/mm2, but in the medial wall significantly higher, 0.5 gland/mm2. The lower density of glands in the maxilly sinus than in the nose, where it is 8-9 glands/mm2, is in complete agreement with lesser requirement of the antral mucosa for moistening, cleaning, and warming of the air. Quantitative histological studies of normal mucosa will form the basis for studies of abnormal mucosa.

Aged↗
PubMed1977

Nasal glands in newborn infants.

The entire mucosa of the nasal septum from four newborn infants was removed, stained by the PAS-alcian blue whole-mount method, and the density of mucous glands was determined in 12 different localities. The interindividual median density was 30.7 glands/mm2 and the median count 13,500 glands. The glands were regularly distributed over the entire respiratory region, but with a significant decrease in density in the posterior half. It has been demonstrated that all glands are laid down before birth, that their density decreases with increasing age until it reaches 8.4 glandss/mm2 at an adult age, and that acute or recurrent acute catarrhal or inflammatory changes of the nose do not lead to the newformation of glands.

Acute Disease↗
PubMed1977

Pathogenesis of nasal polyps.

On the basis of studies on the glands of the nasal mucosa and polyps as well as the structure of the latter, some previous pathogenetic theories are analysed. The authors advance their own theory of polyp formation: Infiltration and oedema in the nasal mucosa result in rupture of the epithelium and formation of granulations which gradually become lined with pseudostratified columnar epithelium. During growth of the polyp there occurs formation of mucous glands which owing to growth of the polyps become long and stretched.

Adult↗
PubMed1976

Density of mucous glands in the normal adult nasal septum.

The entire mucosa from 13 normal nasal septa was stained by the PAS-alcian blue whole-mount method, and the mean density of glandular orifices in 13 localities was determined quantitatively by counts in 4 mm2 fields. The median density within the entire material was 8.4 glands/mm2, with an interindividual variation of +/- 1 gland/mm2. The median number was 15,900 glands, range 10,800-21,800. The distribution of the glands is regular, with little variation between the localities. Density is somewhat, but significantly lower in the posterior quarter of the septum, and there was a significant increase in density into the infero-superior direction.

Aged↗
PubMed1976

Routine procedure for determining goblet cell density in the mucosa of the respiratory tract.

In two normal nasal septa, fine-dissected and stained by PAS-alcian blue whole-mount methods, counts of goblet cells were done in eight different localities in 1, 2, 5, 10, 20, 30, 50, and 100 fields measuring 0.01768 mm2. The median density and range of goblet cells by each mode of counting were compared and the mean deviation determined. Even as little as 2-5 blindly placed counts, which do not take much time, afford in a 4 mm2 area a fairly reliable orientation regarding density, considerably more reliable than an estimate of the density in sections, so often reported in the literature. Determination of the goblet cell density can be included as a routine method in the histopathological diagnosis of mucosal diseases of the upper and lower respiratory tract.

Aged↗
PubMed1976

[Goblet cells in nasal allergy (author's transl)].

After staining of the whole nasal mucosa from a patient with nasal allergy by the PAS-alcian-blue whole mount method, the density of goblet cells was determined quantitatively. In most sections of the nasal septum and of the inferior and middle nasal concha, the density of goblet cells was found to be considerably lower than in normal subjects. While in some sections, in particular posteriorly, the density was the same as in normal subjects, it was nowhere higher. The low density may be due to metaplastic changes of the epithelium which had thickened and lost ciliary cells. Previous statements that the density of goblet cells is increased in nasal allergy could not be confirmed quantitatively, but investigation of larger materials is called for before any conclusions may be drawn.

Adult↗
PubMedDate not supplied

Nasal glands and goblet cells in chronic hypertrophic rhinitis.

Partial turbinectomies were done in 13 patients suffering from chronic hypertrophic rhinitis. The mucous membranes were fine-dissected, and mucous elements were stained and counted using the PAS-alcian blue whole-mount method. Cross-sections were made from the whole-mount specimens. There was a great variety of epithelial types. Comparison of the density of mucous elements in normal patients and patients with chronic hypertrophic rhinitis revealed no statistically significant differences.

Adult↗
PubMedDate not supplied

Experimental surgery on the nose. I. Airflow and goblet-cell density.

In rabbits the nasal vestibule was surgically occluded on one side. The rabbits were observed for varying periods, maximum 90 days. The mucosa of the septum was removed from both sides, stained by the PAS-alcian blue whole-mount method, and the goblet cells were counted. The difference in goblet-cell density between the occluded and open side of the nose was less than expected according to previous reports. A completely abolished air flow for 3 months caused only some increase in density. During the first 16 days there was an increase in density on the occluded as well as on the open side of the nose. This can hardly have been due to altered airflow, but must be attributed to an irritative action by the operation upon the nasal mucosa.

Airway Obstruction↗
PubMedDate not supplied

Experimental surgery on the nose. Changes of the epithelium in the vestibular region at altered airflow.

In 20 rabbits one nostril was closed surgically and the nasal mucosa lying anteriorly in the vestibule was studied 4--90 days postoperatively. On the occluded side, without air-flow, the epithelium--which at this site is normally thickened due to hyperplasia of basal cells--gradually returned to a normal thinner, regular epithelium with increased number of goblet cells. On the patent side, where the airflow was doubled, the cilia were damaged. As early as the 4th day, a process of repair had been initiated, with hyperplasia of basal cells and differentiation of these cells into ciliated and goblet cells. As a result of continued trauma, similar processes continued, but there were no signs of a permanent transformation of the epithelium into squamous epithelium, not even on the 90th day.

Animals↗
PubMedDate not supplied

Mucus production in chronic maxillary sinusitis. A quantitative histopathological study.

A quantitative histological investigation, comprising 47 maxillary sinuses with chronic sinusitis subjected to the whole-mount method, was undertaken principally to determine the degree of mucus production. The goblet cell density in the maxillary sinus was found to be significantly lower (7350 cells/mm2) in chronic sinusitis than in the normal maxillary sinus (9700 cells/mm2). The gland density was 1.2 gland/mm2, which is six times that of the normal maxillary sinus. Several varieties of pathological tubulous glands were encountered; they could be simple and short, long, or branched. These glands are formed during the disease state as a result of basal cell hyperplasia. In addition to new formation of glands, the mucosa in chronic sinusitis also displayed hyperplasia and hyperactivity of the normal tubuloacinous, seromucous glands. It is concluded that the increased mucus production in chronic sinusitis mainly is derived from the newly formed glands.

Adolescent↗