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C Morales Angulo

Publications and source records attributed to C Morales Angulo.

At least 19 recordsLinked to original sources
PubMed2005

[Vestibular drop attacks or Tumarkin's otolithic crisis in patients with Meniere's disease].

INTRODUCTION: Drop attacks (DA) are a sudden fall that comes without warning and without loss of consciousness, with no associated neurological symptoms and normal neurological examination. A certain number of patients with Meniere's disease, develop Tumarkin's otolithic crisis or DA. The purpose of this study is to document the frequency and clinical features of DA in patients with Meniere's disease. METHODS: A cohort of 40 patients with "definitive" Meniere's Disease were followed up between six months and 12 years. The presence and characteristics of Tumarkin's otolithic crisis were recorded. RESULTS: Thirteen (32.5%) patients developed DA during the outcome of their Meniere's disease. The interval between the onset of typical symptoms of Meniere's disease and the DA ranged from less than one year to 18 years. The number of DA varied from 1 to 14. The attacks typically occurred in a flurry during a period of 1 year or less. Six patients had only one DA. No patient requiered treatment for the DA. CONCLUSIONS: Tumarkin's otolithic crisis in Meniere's disease are not uncommon. They can occur at any time during the course of the disease, generally in a flurry of less than one year. Most patients have a spontaneus remission of the DA.

Adolescent↗
PubMed2005

[Universal newborn hearing screening in Cantabria (Spain): results of the first two years].

AIMS: We present the results of the first 2 years of universal newborn hearing screening in Cantabria. MATERIAL AND METHODS: We performed a descriptive study of screening with two levels of transient evoked otoacoustic emissions in 8,836 newborns, diagnostic confirmation with auditory brainstem response, and treatment. RESULTS: The coverage of the first two levels of otoacoustic emissions was 98.4 % and 99.5 %. The incidence of risk factors was 3.08 %. A total of 6.7 % of those studied in the first stage were referred to the second, and 0.7 % of those studied in the second stage were referred to testing of auditory brainstem responses. Of the patents referred to the second stage, 97.6 % attended, and of those referred to the third stage 87.1 % attended. The positive predictive value after the second session of otoemissions was 7.9 %, and the false positive rate was 3.3 %. Sensorineural and bilateral hearing loss was diagnosed in 11 children, and permanent unilateral hypoacousia was diagnosed in one child, representing an incidence of 1.38/1,000 newborns. Sixty percent were diagnosed before the age of 3 months and 100 % before the age of 7 months. Fifty percent began treatment before the age of 6 months and 90 % before the age of 1 year. Of three cochlear implants indicated, two were implanted at 11 and 13 months. The cost was 1.3 3 per child screened and 867 3 for each case diagnosed. CONCLUSIONS: All the objectives of the first and second stages of screening were achieved. The continuity index anticipated for the third stage (87.1 vs 95 %) and access to treatment at 6 months (50 % vs 100 %) were less satisfactory, although these results compare favorably with those of previously published studies.

Evoked Potentials, Auditory↗
PubMed2003

[Epidemiology of Menière's disease in Cantabria].

OBJECTIVES: To know the main epidemiologic characteristics of Meniere's disease in Cantabria. METHODS: All the patients diagnosed of "definitive" Meniere's disease between 1992 and 2002 in Sierrallana Hospital of Torrelavega (Cantabria, Spain) were reviewed. Incidence, prevalence, presence of bilateral disease, age at diagnosis and gender were recorded. RESULTS: A total of 75 patients were diagnosed of "definitive" Meniere's" disease" during this time. The incidence was 3/100,000 people/year, the prevalence 75/100,000, male/female ratio was 0.38. Most frequent age at onset was between 40 and 60 years and bilateral cases were 5.3%. CONCLUSIONS: Meniere's Disease is not uncommon in Cantabria. It is more prevalent among middle aged women. Bilateral cases are rare.

Adolescent↗
PubMed2002

[Audiometric features of familial hearing impairment transmitted by mitochondrial inheritance (A1555G)].

OBJECTIVE: To examine the audiometric patterns of familial hearing impairment due to the A1555G mutation in the mitochondrial DNA. PATIENTS AND METHODS: We include 55 subjects with the A1555G mutation from 6 unrelated families, affected by nonsyndromic sensorineural hearing loss and residing in Cantabria. The A1555G mutation was found in homoplasmy in all the families, except in one family, in which it was in heteroplasmy. Aside from standard history taking and general otolaryngological examination, pure tone audiometry was carried out in all patients. RESULTS: Hearing loss was developed by most of the patients. The auditory defect was a slowly progressive bilateral symmetrical sensorineural hearing loss, affecting mainly the high frequencies. In patients in which aminoglycoside ototoxicity could be excluded, hearing loss usually ranged from mild to moderate, with a late onset. In 17 cases there were previous history of treatment with a ototoxic drugs, and most of them developed severe hearing loss. One of them was deaf-mute. No audometric differences between families with the homoplasmic and the heteroplasmic A1555G mutation were observed. CONCLUSIONS: Patients with the A1555G mutation generally present bilateral symmetrical sensorineural hearing loss, ranging from mild to moderate, slowly progressive, which is obvious approximately in the second decade of life and affects specially the high frequencies. Hearing loss severity is increased by treatment with aminoglycosides.

Adolescent↗
PubMed1999

[Non-syndromic familial hearing impairment transmitted by mitochondrial inheritance].

OBJECTIVE: To determine the clinical features and mode of inheritance of hearing impairment observed in several members of a Spanish family with putative genetic susceptibility to ototoxicity induced by aminoglycoside antibiotics. MATERIALS AND METHODS: In 14 patients belonging to the same family, an interview, otological examination and audiometry were carried out. Three of these patients also underwent a study of brainstem auditory-evoked potentials. A genetic study was made of 11 patients and 9 unaffected relatives to determine the mode of inheritance of the hearing impairment and to detect associated mutations. RESULTS: Most of the patients developed hearing loss before the age of 8 years, particularly for high frequencies. In almost all of them, there was no further evolution. Six patients had previous exposure to ototoxic drugs. Three patients had sudden hearing loss. In 2 of the 3 patients examined for brainstem auditory-evoked potentials, the hearing impairment was of cochlear origin. The genetic study detected A1555G mutation in the mitochondrial DNA of all the maternal relatives studied. CONCLUSIONS: Mitochondrially-inherited sensorineural hearing loss should be suspected in families with a maternal transmission of the disorder and more than one relative with aminoglycoside-induced hearing loss.

Acoustic Impedance Tests↗
PubMed1999

[Anaplastic carcinoma of the thyroid in a young man. A report of a case].

Anaplastic thyroid carcinoma is a tumor that has a very ominous prognosis, and is characteristic of people older than 60 years. Generally occurs as a neck lump of rapid growth rate, arousing compressive symptoms on nearby structures. We report the case of a 29-year-old patient who presented an anaplastic thyroid carcinoma. He was treated with surgery, chemotherapy and radiotherapy, but died 10 months after being diagnosed.

Adult↗
PubMed1999

[Benign cervical mesenchymoma].

Mesenchymoma are growths made up for two or more mesenchyme derivatives that normally not joint in the same tumor, with the exception of the connective tissue which appears in all tumors of mesenchymal lineage. Benign mesenchymoma is a rare tumor more frequent in extremities and peri-renal area or, very rarely in head and neck territories, being the oropharynx the most encountered sitting in the latter place. The paper reports a clinical case of benign cervical mesenchymoma of a long course, more than 20 years, and big size, asymptomatic and diagnosed through fine needle biopsy. After total removal the histological examination showed a composite growth of extended areas of fibrous tissue associated to vessels and other zones of ripe fat tissue.

Aged↗
PubMed1998

[Overexpression of p53 protein in epidermoid carcinoma of the pyriform sinus].

Mutation of the p53 protein may be the commonest genetic event in the development of malignant neoplasms in humans. We analyzed the immunohistological expression of p53 in tissue sections from 51 patients with squamous cell carcinoma of the pyriform sinus who were treated with surgery and postoperative radiotherapy. Overexpression of p53 was found in 37 (72.5%) tumors. No correlation was found between p53 overexpression and clinical and histopathological parameters. Recurrence and overall survival did not differ between p53-positive and p53-negative cases.

Adult↗
PubMed1998

[Temporal artery biopsy].

The biopsy of the temporal artery is a necessary procedure in order to gain a certain diagnosis of temporal arteritis. Is an easy method and customarily sure, but needing a knowledge of the clinical picture of this arteritis and of it surgical anatomy. The AA. explain the technique they follow.

Biopsy↗
PubMed1996

Mucormycosis of the sphenoid sinus in an otherwise healthy patient. Case report and literature review.

Paranasal and rhinocerebral mucormycosis refers to uncommon opportunistic fungal infections, reported to occur especially in association with diabetic acidosis (the most common), immunosuppressive therapy, malignancy, or other chronic debilitating disorders. However, patients who have no underlying disease have occasionally been affected. According to the literature reviewed, only 13 well-documented cases without any predisposing factor have been previously reported. We describe a unique case of sphenoidal mucormycosis in an otherwise healthy individual, and the first patient to present with headache as the only symptom. We emphasize the importance of a high index of suspicion for early diagnosis and prompt management.

Humans↗
PubMedDate not supplied

[Program of hearing loss early detection in newborn infants in Cantabria. Results of the first year of activities].

AIMS: To report the findings in the first year of follow-up of the Cantabrian Program to screen newborn babies for congenital permanent hearing loss. METHODS: The study population consisted of infants born during a year period in Cantabria (Spain). Universal hearing screening by transient evoked otoacoustic emissions (TEOAE) in 2 stage protocol was performed. Infants with failure scores in these 2 stages and those with risk factors for hearing loss were referred for diagnostic evaluation with auditory brainstem response. Hearing aids were recommended for those infants who had bilateral hearing loss and referrals to infant speech and language rehabilitation. RESULTS: Out of the 4117 eligible babies, 3987 were studied. One hundred and ten (2.6) had risk factors for hearing loss, 3.5% were referred for audiological assessment and 1.2/1000 were diagnosed as having a permanent hearing loss. The false-positive rate was 0.72% after the two-stage screening procedure was performed. Positive predictive value for permanent hearing loss was 10%. CONCLUSIONS: During the first year working with the Cantabrian Screening Program for congenital permanent hearing loss in newborn babies, the most part of the proposed aims have been achieved.

Age Factors↗
PubMedDate not supplied

[Sensorineural hearing loss in cerebral palsy patients].

INTRODUCTION: Cerebral palsy (CP) is the most common chronic motor disorder in children and frequently associates sensorial pathology. The objective of our study was to establish the prevalence and characteristics of sensorineural hearing loss in children with CP. METHODS: We performed a retrospective study of patients born between the years 1975 and 2004, diagnosed of CP in the "Marqués de Valdecilla" University Hospital. Clinical data were collected including the presence of sensorineural hearing loss, age at diagnosis, treatment and associated pathology. RESULTS: Sixty four patients had confirmed CP. Audiological testing had been performed in thirty patients (47%) of them 18 (60%) had sensorineural hearing loss (12 bilateral and 6 unilateral). In thirteen cases hearing loss was associated with mental retardation. The age at diagnosis ranged from 3 months to 7 years (mean 23.2 months). Eight patients were treated with hearing aids and one with a cochlear implant. CONCLUSIONS: Sensorineural hearing loss is frequent in CP patients. Management of this problem is difficult in this setting because of the motor disorder and the associated pathology. Early audiological assessment is very important to improve the language outcome in these children.

Cerebral Palsy↗
PubMedDate not supplied

[Simultaneous bilateral facial paralysis].

Simultaneous bilateral facial paralysis (SBFP) is very rare, but it can present itself as the first complaint in a wide spectrum of diseases and a comprehensive evaluation must be completed. Bilateral Bell's Palsy can be diagnosed only when all other possible causes have been excluded. The prognosis and treatment for SBFP is dependent upon the underlying etiology. We present four cases of SBFP seen in our department which were finally diagnosed as leukemic infiltration, sarcoidosis, Bell's Palsy and demyelinating polyneuropathy (probably Guillain-Barré syndrome). The most important etiologies of the SBFP and the management of this entity are discussed.

Adult↗
PubMedDate not supplied

[Verrucous carcinoma of the larynx].

The present work shows a retrospective study of 11 cases of verrucous carcinoma of the larynx from data collected at Marqués de Valdecilla Hospital for ten years. All patients were males. Glottis was the most common site involved (10 cases). Eight patients were treated with partial surgery and in two cases total laryngectomy was performed. One patient refused treatment. Five-year survival rates were 100% in the ten patients treated. Verrucous carcinoma of the larynx is a well differentiated variant of squamous cell carcinoma. Surgical treatment is necessary for the primary lesion without neck dissection. Radiotherapy is not indicated because the possibility of anaplastic transformation. Prognosis is excellent after surgical treatment.

Adult↗
PubMedDate not supplied

[Sphenoidal metastasis of laryngeal carcinoma].

Metastatic tumors to the nose and paranasal sinuses are very uncommon and metastases to the sphenoid sinus are exceedingly rare. The most common tumor sites from which sphenoid metastases arise are the kidney and the lung. Distant metastases from laryngeal carcinoma are rare, the most common sites being the lungs, skeletal system, and liver. We report a patient with a supraglottic laryngeal carcinoma who had metastases to the sphenoid sinus. The management of this entity is described and cases reported in the literature are reviewed.

Adult↗
PubMedDate not supplied

[Cholesterol granuloma of the petrous apex].

Cholesterol granuloma of the petrous apex is an inflammatory granulation tissue response to the presence of cholesterol crystals. It is not generally associated with middle-ear pathology. CT and MRI are fundamental for diagnosis. MRI is more specific and shows a well-circunscribed mass with high signal intensity on both T1 and T2 weighted images. We present a case of cholesterol granuloma of the petrous apex that was previously diagnosed as cholesteatoma. We emphasize the importance of preoperatory differentiation of the lesion from cholesteatoma. Cholesterol granuloma does not require full excision of the lesion. Drainage and permanent aeration is usually sufficient.

Adult↗
PubMedDate not supplied

[Use of embolization in the treatment of pulsatile tinnitus secondary to dural arteriovenous fistula].

Three cases of dural arteriovenous fistula (DAVF) in patients who consulted for pulsatile tinnitus are reported. All were treated successfully by embolization. If DAVF is suspected, angiography of the carotid and vertebral arteries should be performed to confirm its presence and to identify sources of blood flow and venous drainage. If treatment is needed, embolization, surgery, or radiotherapy may be indicated either separately or in combination therapy. The numerous branches and site of the fistula make therapeutic embolization the procedure of choice for many cases.

Carotid Artery, Internal↗