Biomedical subjects

C Morales Angulo

Publications and source records attributed to C Morales Angulo.

21 records · Page 2Linked to original sources

PubMedDate not supplied

[Prognostic significance of DNA content measured by flow cytometry in supraglottic laryngeal carcinoma].

Eighty-five patients with squamous that were cell carcinoma of the supraglottis treated surgically in the Department of Otolaryngology at the Marqués de Valdecilla Hospital in Santander (Spain) over a 10-year period from January 1, 1978 to December 31, 1987 were studied retrospectively. In 81 cases a flow cytometric study was made from the surgical specimen included in paraffin blocks, to determine the DNA index and the percentage of cells in the S phase of the cellular cycle. An statistical analysis was made to determine the correlation between these parameters and survival was analyzed using the Kaplan-Merer method. Survival curves were compared using the log-rank test. In 67 cases (82.7%) DNA content was diploid and in 14 cases (17.3%) it was aneuploid. The percentage of cells in S phase was 3.8 and 55.4, with a mean value of 15.19. Comparison of with the five these parameters years survival showed no statistical differences between groups, although tumors with more than 19% S phase had worse prognosis (p < 0.1) and tumors in advanced stages were more frequently aneuploid and had higher S phase values (p = 0.1).

Adult↗

PubMedDate not supplied

[Nasal sinus adenocarcinoma in patients exposed to wood dust in the Community of Cantabria, Spain].

OBJECTIVE: To study the incidence and clinical and histological features of sawdust-related nasosinusal adenocarcinoma (SRNA) in the Community of Cantabria. MATERIAL AND METHODS: A retrospective study was made of all patients diagnosed as SRNA in 9 years. RESULTS: Ten male patients, ranging in age from 56 to 64 years, were diagnosed as SRNA in this period. The most common location was the ethmoid. Histologically, six tumors were papillary and four were mucinous. Five patients received combined treatment (surgery and postoperative radiotherapy), one surgery alone, two radiotherapy, and one chemotherapy. The 5-year survival rate was 28.5%. The most frequent cause of death was local recurrence. CONCLUSIONS: The incidence of SRNA in the Community of Cantabria is less than 0.2 cases per 100,000 inhabitants/year. SRNA occurs almost exclusively in men and has an occupational origin. Papillary adenocarcinoma is the most frequent histological type. The treatment of choice is surgery associated with postoperative radiotherapy. The long-term prognosis is poor, so preventive measures to reduce exposure to sawdust are fundamental in risk groups.

Adenocarcinoma↗

PubMedDate not supplied

[Rendu-Osler-Weber disease (hereditary hemorrhagic telangiectasia). Report of 30 cases].

OBJECTIVE: To study the prevalence and modes of presentation of hereditary hemorrhagic telangiectasia (HHT) in Cantabria, Spain. MATERIALS AND METHODS: A retrospective study was made of all patients diagnosed as HHT in Cantabria in the last 20 years (1976-1995). The presence/absence of family history, recurrent nosebleed, mucosal and cutaneous telangiectasia, visceral involvement, and course of the disease were evaluated. RESULTS: Thirty patients ranging in age from 17 to 75 years were diagnosed as HHT in the study period. Most of them had a family history of recurrent nasal bleeding. The main symptom was nosebleed. Pulmonary arteriovenous fistulas were found in 7 patients and gastrointestinal manifestations in 10 patients. Five patients died of complications directly attributable to the disease. CONCLUSIONS: The minimum prevalence of HHT in Cantabria is 1:12,200, Patients with recurrent nosebleed, particularly if a family history of epistaxis is present, should undergo exploration of the oral cavity for telangiectasia. Early diagnosis of HHT can help to avoid unnecessary diagnostic procedures and contribute to the early detection of associated visceral malformations. The treatment of HHT should be individualized.

Adolescent↗