Biomedical subjects

C Nezelof

Publications and source records attributed to C Nezelof.

At least 163 records · Page 9Linked to original sources

PubMed1975

[Thymic and parathyroid agenesia (DiGeorge's syndrome). Apropos of a case with abnormal vena caval return].

A child with a complete absence of thymus and parathyroids (Di George's syndrome) associated with a cardiac malformation (truncus arteriosus and abnormal caval venous return) is described ; the child died at the age of 1 month. An exchange-transfusion, performed at 4 days of age induced a mild graft versus host reaction which could only be recognized histologically and distorted the results of immunological tests. On this occasion, the main clinical, anatomical and immunological features of the Di George's syndrome are reviewed. They suggest a possible relationship between the severity of the cardiac malformation and the more or less complete character of the dysgenesia of the thymus and the parathyroids.

Abnormalities, Multiple↗

PubMed1975

[Renal cystadenoma in children. Apropos of 5 cases].

The multilocular renal cystadenoma is a benign, rather uncommon tumor occurring in childhood (one case for 40 Wilms tumors). The clinical pathological study of five cases and the review of cases published in the literature show that this tumor, like all cystadenomata, is constituted by isolated cysts lined with cubic epithelium and inserted into each other. These cysts are included into mature mesenchymatous tissue. The renal cystadenoma appears as a large, regular, spheric mass, sharply demarcated from the pelvic cavities and renal parenchyma. Its volume is the main clinical sign. Occasionally, angiographic and echographic investigations may provide additional useful data. In some cases, the renal cystadenoma may be difficult to distinguish from a well differenciated cystic nephroblastoma. The differential features are emphasized and discussed. The renal cystadenoma must be regarded as a hamartoma developed from some metanephrogenic blastematous areas excluded from the normal embryogenetic process. The term of renal cystadenoma emphasizes the neoplastic nature and the macroscopic appearance of this tumor and must be preferred to designate this lesion.

Child, Preschool↗

PubMed1975

[Benign chondroblastomas of bone. Anatomo-clinical and ultrastructural study apropos of 11 cases].

The authors have observed 9 cases of benign chondroblastoma of bones. After a review of the literature they recall that this is a rare condition (1% of bone tumors). That it is twice more frequent in males than in females. Aged 10-20, at the level of growing epiphysis shoulder and knee are the more common sites. The X-rays pictures are described, as well as the pathological findings. Pathological features close to those noted in aneurismal bone cysts were often encountered. The ultra-structure of these tumours was also studied. This type of tumour is essentially benign, however the association of aneurism-like pictures increase the incidence of recurrences.

Adolescent↗

PubMed1975