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Biomedical subjects

C Osorio

Publications and source records attributed to C Osorio.

At least 73 records · Page 4Linked to original sources
PubMed1977

[Physical exercise as a functional test of hgh secretion (author's transl)].

The efficiency of L-dopa and exercise tests have been compared to diagnose the lack of human growth hormone. Both tests gave similar results. The exercise test is recommended as a screening method in large populations to discard growth inhibition due to HGH deficiency, because of its easy, quick and painless application to patients.

Adolescent↗
PubMed1977

[Serum levels of testosterone, follicie-stimulating hormone and luteinizing hormone in normal human males (author's transl)].

The serum levels of testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) have been measured in healthy man of different ages to stablish their normal values in the population of Granada. The serum levels of testosterone, FSH and LH have been compared to each other in each age group. No clear relation between these hormones was found at any age.

Adult↗
PubMed1976

Simultaneous measurement of renin and renin substrate concentration in human plasma by a simple kinetic method.

A simple kinetic method is described for measurement of plasma renin concentration (PRC) and plasma renin substrate concentration (PRS) in human plasma. It is based on the radioimmunological determination of angiotensin I generated when a plasma sample is incubated at 37 degrees C for 2, 4, 6 and 8 h. The use of exogenous renin and renin substrate preparations are not required. The specific velocity constant of reaction (K) was used to deduce the PRC. PRS determination was based on the stoichiometric conversion of renin substrate to angiotensin I. PRC and PRS have been determined in plasma from healthy subjects, plasma from health subjects 3 h after oral furosemide administration and in plasma from women, 12-20 weeks normally pregnant.

Angiotensin II↗
PubMed1976

[Kinetics of renin reaction in rat plasma (author's transl)].

Important kinetic aspects of renin reaction were studied in order to evaluate the parameters that regulate the formation rate of angiotensin I. This rate decreased throughout the incubation period of normal rat plasma and it showed a linear increase when plasma was incubated with renin-substrate. When renin was added to normal rat plasma a plateau in the angiotensin I formation rate occurred after 4-6 hours. When plasma samples containing increasing amounts of renin-substrate were incubated, the velocity of their reaction increased in proportion to the renin-substrate concentration. Under these incubation conditions, the reaction between endogenous renin and renin-substrate in normal rat plasma, proved to be a first kinetic order with respect to the substrate.

Angiotensin II↗
PubMed1976

Electron microscopic evidence for phagocytic properties of human peripheral mononuclear cells cultured with PHA.

The time course of the ultrastructural changes induced in human peripheral mononuclear cells, when cultured with PHA, has been studied. In addition to findings common to many mitotic cells, such as an increase in nuclear and nucleolar size, the presence of free polyribosomes, glycogen and lipid globules in the cytoplasma, and a high number of mitochondria, agglutinating properties due to PHA per se were observed in the first 12 hours. At 72 hours certain cells developed phagocytic-like properties, i.e. they were able to incorporate both material from the extracellular compartment and syngeneic cells. These results are discussed suggesting the possible presence of macrophages in culture or the ability of activated T cells to express it.

Cells, Cultured↗
PubMed1976

[Ceruloplasmine in schizophrenic and in epileptic patients (author's transl)].

Ceruloplasmine was measured in serum of normal, schizophrenic and epileptic patients through the use of oxidase and immunological methods. The measurements were correlated to find: the reliability of oxidase method as an index of ceruloplasmine concentration and the immunological identity of this protein in the three groups of individuals. The results showed that the oxidase method served as a good index of ceruloplasmine concentration in the sera and that an immunological identity among the three groups exised. A significant correlation between the serum oxidase activity and the ceruloplasmine immunological determination was, further, observed.

Ceruloplasmin↗
PubMed1976

[Immunological and oxidase measurement of ceruloplasmin in pregnant women and newborn (author's transl)].

Ceruloplasmin measurements were made by oxidase and immunochemical methods in serum from three groups of people, normal, pregnant women and their newborns. Whatever the method ceruloplasmin showed a decrease in the newborns and an increase in pregnant women as compared with the normal controls. The three groups showed a significant correlation between both measurement. The correlation ratio between the two methods of measurement in the newborns is significantly different from the pregnant and the normal groups. It appears that ceruloplasmin in the newborns' serum has a lower oxidase activity per molecule than that from adult's serum.

Ceruloplasmin↗
PubMed1975

Behaviour of lymphocytes from cancer patients and normal individuals cultured with phytohaemagglutinin.

Blood lymphocytes from cancer patients with solid tumours without any previous immunosuppressive treatment and from normal individuals, were cultured in vitro with a wide range of phytohaemagglutinin (PHA). Sixty two per cent of all the cancer patients studied show a minimal of no response to PHA in comparison with the normal population. The rest (38%), show a quantitative identical response than normals. However, the maximal response in these patients occur in the high PHA doses, while the normal individuals show their maximal activity with low PHA doses. The low or no PHA response showed by the 62% of patients, may indicate they have impaired cellular immunity. The high response showed by the other 38%, may indicate that the patients of this group have high cellular immunity capacity. This immunity, however, higher PHA doses are required to reach the maximal response compared with the seems to be different from that of normal individuals, since higher PHA doses are required in cancer patients to reach maximal response. These results also suggest that a large range of PHA doses may be important to detect the degree of cellular immunity in cancer patients compared with the normal population. One or two random PHA doses, may not show a distinction.

Humans↗