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C Paganelli

Publications and source records attributed to C Paganelli.

34 records · Page 2Linked to original sources
PubMed1992

[Leiomyosarcomas of the stomach: a report of 3 clinical cases and a review of the literature].

Three consecutive malignant smooth-muscle gastric tumor cases are reported. Digestive endoscopy allowed a correct diagnosis in 2 out of 3 cases, when neoplasias were ulcerated, enabling a deep endoscopic biopsy. On the contrary, in the third case the endoscopic diagnosis was a benign leiomyoma and the endoscopic biopsies were completely negative. Even CT scan was not able to reveal the malignant nature of the disease in this patient. Surgical procedures performed were: polar superior gastric resection, Billroth I partial gastric resection and extended total gastrectomy. In one patient, regional lymph nodes were positive for metastases. The patient who died at 6 months from surgery had a large (approximately 12 cm) neoplasia of the gastric fundus.

Adult↗
PubMed1991

Role of fine-needle aspiration biopsy in the assessment of renal masses.

Clinical and histological control of fine-needle aspiration biopsy (FNAB) diagnosis of 72 kidney masses observed between 1981 and 1988 confirmed 34 benign and 33 malignant lesions, but did not confirm four malignant and one benign lesions, giving a total diagnostic accuracy of 93.05%. The role of FNAB in selecting cases to be sent to surgery was investigated by comparing the incidence of useful surgery (for benign and primary malignant neoplasias) and the incidence of useless surgery (for nonneoplastic lesions and secondary malignant neoplasias) in nephrectomized patients who either had (group A, 27 patients) or didn't have (group B, 198 patients) preoperative FNAB. The differences were highly significant (P less than 0.001). Furthermore, patients operated for malignant neoplasias (20 in group A; 117 in group B) displayed highly significant differences (P less than 0.001) with respect to renal vein infiltration (1 in group A versus 22 in group B) and local-regional lymph node metastases (1 in group A versus 15 in group B). In conclusion, FNAB is a reliable method for selecting cases for surgery and for aiding in the diagnosis of malignant neoplasias.

Biopsy, Needle↗
PubMed1991

Role of fine-needle aspiration biopsy in the assessment of sacrococcygeal masses.

While fine-needle aspiration (FNA) allows the diagnosis of deep masses, it does not always permit histologic classification. In the case of sites such as the sacrococcygeal region, in which a large number of benign or malignant, epithelial or connective, primary or secondary tumors may arise, it is necessary to choose between conservative treatment and radical surgery. This means that preoperative diagnosis must be as certain as possible. In order to increase the diagnostic accuracy of the method, when even immunohistochemistry is of no aid, it is useful to examine the histologic architecture of the specimen by preparing cell blocks from the aspirates. We report the comparative findings from the examination of the histologic architecture of tissue fragments embedded in methacrylate prepared from the aspirates of four cases of tumors: two chordomas, one metastasis of renal clear-cell carcinoma, and one of mucus-secreting carcinoma, all of them arising in the sacrococcygeal region.

Aged↗
PubMed1982

Role of diffusion in gas exchange of the avian egg.

The pore system of the avian eggshell provides a unique exchange surface for the transport of gases. The dimensions of the microscopic pores do not change with time, and gas transport through them is essentially limited to diffusion. According to Fick's law of diffusion, eggshell conductance of a given gas will vary directly with the diffusion coefficient of the gas. This principle is illustrated by monitoring changes in air space CO2 in metabolizing eggs subjected to changes in barometric pressure or to substitutions of He and SF6 for N2 in the ambient atmosphere.

Animals↗
PubMed1977

Reduction of pore area of the avian eggshell as an adaptation to altitude.

Standard measurements of water vapor conductance in units of mg of H(2)O . day(-1) . torr(-1) (SI equivalent is mg of H(2)O . day(-1) . pascal(-1)) of fresh eggs of the red-winged blackbird (Agelaius phoeniceus) and the native chicken of India (Gallus gallus) collected at altitude are significantly less than those of eggs of the same species collected near sea level. This decrease is caused by a reduction of the total effective pore area of the eggshell at altitude. It appears to be proportional to the reduction in barometric pressure and the simultaneous increase in the diffusion coefficient of water vapor. Thus, reduction in pore area offsets increased diffusivity at altitude, and water vapor loss through the eggshell at any altitude remains the same as at sea level. The data suggest a structural adaptation of the shell to altered diffusivity of gases at altitude in order to prevent excessive water loss of eggs during natural incubation.

Journal Article↗
PubMedDate not supplied

Role of mast cells in wound healing process after glass-fiber composite implant in rats.

Glass-fiber composites are frequently used in dentistry. In order to evaluate their biocompatibility we tested, in an experimental model "in vivo", their tissue response pointing our attention on presence of mast cells (MCs) and fibrotic process. Sprague Dawley rats were used for the experimental design. The fibers were introduced in a subcutaneous pocket along the middle dorsal line between the two scapulas for 7, 14 or 21 days. At the end of the treatments the skins were excised and then processed for Toluidine Blue, to determine the presence of MCs, and Picrosirius Red staining, to evaluate the presence of fibrotic tissue. Our preliminary results showed and increase of both MC number and deposition of collagen type I, which characterized the fibrotic tissue. So, subsequent aims of our study were to evaluate the role played by MCs in tissue fibrosis and to give a possible explanation regarding the mechanisms that were responsible of biological response observed, through the analyses of some proteins, such as metalloproteinase-2 (MMP-2), its inhibitor (TIMP-2) and transforming growth factor-beta (TGF-beta). Our data confirmed the involvement of TGF-beta, released by MCs, in the disruption of the equilibrium between MMP-2 and TIMP-2 that were implicated in the enhancement of fibrosis. In summary, this study demonstrate that this type of materials induced an inflammatory response at the site of implant and help to clarify what type of mechanism and which proteins are involved in this biological response. Nevertheless, more extensive investigations are in progress to better evaluate the inflammatory process.

Animals↗
PubMedDate not supplied

[In vitro study of amalgam corrosion].

AIMS: In the dental field, the aim of the research was to evaluate, through a standardized system, the factors influencing the corrosion of dental alloys in different clinical conditions with various types of amalgams and/or solution parameters. METHODS: A 6-hole corrosion cell was used according to ASTM G5-95 protocol. RESULTS AND CONCLUSIONS: It is well known that free surface corrosion is uncommon in the oral cavity in the case of most dental alloys. But localized corrosion, either as pitting or as crevice corrosion, might occur. The clinical conditions affecting amalgam corrosion may be detectable in localized corrosion, in particular because of cathodic/anodic surface behaviour coupling.

Corrosion↗
PubMedDate not supplied

[Emergency endoscopic sphincterotomy in acute lithiasic cholangitis].

Emergency endoscopic sphincterotomy in acute cholangitis for bile duct stones should be the first choice treatment in patients with and without gallbladder. In fact, emergency surgery carries higher mortality and morbidity rates. Urgent biliary drainage, easily and quickly obtainable by endoscopy is the major goal. Bile duct stone clearance can be attempted subsequently, when the patient general conditions are stable. Elective open surgery can be performed thereafter, if indicated, with less risk. This experience is clearly shown by many surgical and endoscopic, mainly retrospective, studies.

Acute Disease↗
PubMedDate not supplied

Fine needle aspiration biopsy in the diagnosis of intrathoracic masses.

During a 3.5-year period (January 1, 1987, to June 30, 1990) 420 percutaneous fine needle aspiration (FNA) biopsies were performed on 390 patients (309 males, 81 females) suffering from one or more intrathoracic, radiologically visible lesions. Aspirations were carried out using 21- or 23-gauge Chiba needles under fluoroscopic or computed tomographic control. The aspirates were used to make minibiopsies and cytologic smears. Diagnosis was possible in 373 cases (95.64%): on the first pass in 344 cases, on the second in 28 cases and on the third in 1. In 17 cases (4.36%) the aspirate was inadequate for diagnosis. There were complications in 10 cases (2.56%) (9 pneumothorax and 1 hemophtysis) requiring intensive care. The 373 percutaneous FNA biopsy diagnoses included 256 malignant tumors (68.63%), of which 234 were primary and 22 were secondary, and 117 benign lesions (31.37%), 5 of them neoplastic and 112 nonneoplastic. Three hundred two of 373 percutaneous FNA biopsy diagnoses were followed (80.96%). One hundred twenty-three follow-ups were histologic (40.73%), including secondary tumors, which could be compared with the primary histotype. Twenty-eight follow-ups were cytologic (9.27%), and 151 were clinical (50.00%), using progression of the disease or the beginning of chemoradiotherapy as a criterion for malignancy and a stable condition or regression of the lesion with nononcologic medical treatment as a criterion for benignity. Percutaneous FNA biopsy diagnoses were confirmed in 288 cases (221 true positives and 67 true negatives) and unconfirmed in 14 (1 false positive and 13 false negatives). Specificity, sensitivity, negative predictive value, positive predictive value and total diagnostic accuracy were, respectively, 98.52, 94.44, 83.75, 99.54 and 95.36%. The histologic typing accuracy of percutaneous FNA biopsy on 70 specimens of surgically removed malignant epithelial neoplasias was 70.00%. These results confirm that percutaneous FNA biopsy is a reliable method of diagnosing intrathoracic masses and reduces the need for diagnostic thoracotomy.

Adult↗
PubMedDate not supplied

[Aggressive ulcerous stomatitis due to the herpes simplex virus in an allogeneic bone marrow transplant. A clinical case].

Aggressive ulcerative HSV stomatitis was observed in a patient 10 months after allogeneic bone marrow transplantation. The patient was affected by acute myeloid leukemia (LMA) in second remission and, after bone marrow transplantation, supported a severe graft versus host disease. Intravenous acyclovir was administered during 22 days and ulcerative stomatitis completely healed.

Acyclovir↗
PubMedDate not supplied

[Clinico-histological evaluation of surgical orthodontic treatment for fused teeth].

Seeking an evaluation pattern for periodontal wounds following the surgical section of two fused teeth healing, the authors caused in an animal a similar lesion. After that, they valued the undergoing to pressure or traction periodontal re-organizing and the histological-clinical data showed a tissues favourable repair.

Animals↗
PubMedDate not supplied

[Carotid chemodectoma: a clinical case report and review of the literature].

Carotid chemodectoma (CC) is a very rare neoplasia. It originates from Type 1 main cells of the carotid body and affects both sexes almost in the same proportion (mostly in the fourth and fifth decades). It can be on a familiar basis (5-10%) and in these cases it is more frequently multicentric, being sporadically found in association with other paragangliomas. CC is a slow-growing neoplasia, locally aggressive and it can give metastases to regional lymph nodes and surrounding anatomical structures. Once surgically removed, it can reoccur in a small percentage of patients. Early diagnosis is of the utmost importance and surgeon's skill is fundamental as well as awareness of the real nature of the disease. Surgical treatment of CC is difficult and demanding, for the close relation of CC to the neighbouring neurovascular structures. The authors report a case of CC radically operated on. Clinical parameters are analysed as well, and Literature is reviewed.

Carotid Body↗
PubMedDate not supplied

[Role of p53 gene in colorectal neoplasms].

A prospective study on the role of the p53 gene in sporadic colorectal neoplasms is presented and the level of mutant p53 protein was measured in the tissue removed during colonoscopy from: patients previously operated for colorectal malignant neoplasms, patients with active neoplasms, first degree relatives and during regular checks. 72% of patients with an active tumour showed a positive p53 and 38% in follow-up checks. Longer follow-up periods and a major number of patients are necessary to assess the prognostic importance of the p53 protein.

Colorectal Neoplasms↗