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C Perrin

Publications and source records attributed to C Perrin.

At least 163 records · Page 9Linked to original sources
PubMed1993

[Erythroderma disclosing transformation of refractory anemia with excess of blasts into lymphoblastic leukemia].

We report a case of erythroderma revealing lymphoblastic leukaemia occurring immediately after myelodysplasia. The patient was an 87-year old man admitted for poor general condition, lymph node enlargement and pruriginous oedematous erythroderma. Laboratory examinations showed tricytopenia, bone marrow invasion by lymphoblasts in a myelodysplastic environment of the refractory anaemia type with excess of blasts, and a cutaneous lymphocytic infiltrate with non-blastic lymph node reaction. Owing to its morphological and immunohistological features, the lymphocytic infiltrate was regarded as non-specific. We could not help comparing this case to the other non-specific cutaneous lesions of refractory anaemia which usually reflect transformation into leukaemia.

Aged↗
PubMed1993

[Olfactory esthesioneuroma (esthesioneuroblastoma). A pathologic study of 7 cases].

With an histological, immunohistochemical study of 7 cases of olfactory esthesioneuromas (4 of them had an ultrastructural study), our purpose was to revise the problem of the too often ambiguous terminology and of the different histological lower classes classifications of these tumors. Our own results and the literature demonstrate that they are polymorphic. In standard histology, they are often right diagnosed but an immunohistochemical study can be useful and an ultrastructural study absolutely necessary for a reliable diagnosis. For an easier nomenclature, we advise to use only one terminology for these tumors = olfactory esthesioneuroma. But, because of their important polymorphism, we keep to an histological lower classes classification according to their degree of differentiation in light microscopy: well differentiated tumors (old esthesioneuroepitheliomas), moderately differentiated tumors (old esthesioneurocytomas), poorly differentiated tumors (old esthesioneuroblastomas and so on described as neuro-endocrine carcinomas by Silva and al).

Adolescent↗
PubMed1993

[Malignant transformation of juvenile-type laryngeal papillomatosis].

Juvenile laryngeal papillomatosis is characterized by benign budding tumors, developing from the endolaryngeal epithelium. Because the evolution of these tumors is unpredictable, choice of the best therapy is difficult. We report two cases where invasive juvenile laryngeal papillomatosis, progressively colonized the trachea and bronchi. Malignant transformation occurred without carcinoma predisposing factors. In both cases patients died after pulmonary dissemination. We discuss the role of the human papilloma virus and the high interest of viral typing, for an early diagnosis of possible degeneration. The choice of the best therapy, chemotherapy, CO2 laser, alpha interferon or auto-vaccination will depend on the type on the papilloma virus.

Adult↗
PubMed1993

[Focal epithelial hyperplasia. An unusual clinical aspect].

We report a case of focal epithelial hyperplasia in a child born in France of Algerian parents. The clinical appearance was unusual in that certain lesions were verrucous and pediculate. A virological study revealed the presence of papillomavirus 32, one of the two types of HPV specifically associated with this entity.

Africa, Northern↗
PubMed1993

[An original technique of reconstruction of the cricoid cartilage by vitalized scapular flap. Application to pharyngolaryngeal carcinology].

A personal technique for cricoid reconstructive surgery is presented and discussed. A transfert of a free living scapular flap by microvascular anastomoses is used for reconstructing half cricoid resection. We can with this technique increase the number of partial laryngectomy in patients with squamous cell carcinoma. Two techniques are possible: The half anterior laryngectomy conserves only the half posterior cricoid and the twice arytenoids. The half lateral laryngectomy conserves one arytenoid and a half cricoid.

Cricoid Cartilage↗
PubMed1993

[Reconstruction of the mandibular symphysis using a revascularized free flap of the scapula. Surgical technic].

In cases of surgically removed mandibular symphysis malignancies, the bone and mouth floor were reconstructed using osteo-musculo-cutaneous flaps. In our experience, the latter provide the best results. Removed in dorsal decubitus, they allow floor replacement. During the dissection of the tumor site, we also preserve labial and chin structures, which favours a good restoration of phonation and swallowing.

Anesthesia↗
PubMed1992

[Bacillary epithelioid angiomatosis in AIDS. Two cases].

Bacillary angiomatosis is a newly recognized multisystem opportunistic infection seen in the human immunodeficiency virus infection. The disease is marked by papular and nodular vascular skin lesions that clinically resemble Kaposi's sarcoma. Histologically, the lesions are different and show clusters of bacteria showing the structure of Gram negative bacilli staining with Warthin-Starry stain. Transmission electron microscopy shows that the organisms (1 to 2 microns) have a trilamellar wall structure. Treatment with oral erythromycin (2 to 3 g a day) for 2 to 4 weeks rapidly leads to resolution.

AIDS-Related Opportunistic Infections↗
PubMed1992

Acral hyperpigmented macules and longitudinal melanonychia in AIDS patients.

Two patients with AIDS are described who developed acral hyperpigmented macules of the fingers, palms and soles, buccal mucosa and genitalia, associated with longitudinal melanonychia. These pigmentary changes seemed to be independent of zidovudine and were associated in one with diffuse melanoderma and elevated levels of alpha-MSH. Histological and ultrastructural studies showed an increase of the dendrites and pigmentation of the melanocytes and few melanosomes in the keratinocytes.

Acquired Immunodeficiency Syndrome↗
PubMed1992

Escherichia coli cellulitis: two cases.

We report two cases of cellulitis of the legs occurring in adults where Escherichia coli (E. coli) was, or probably was, the causative bacterial agent. E. coli and other gram-negative bacilli cellulitis are rarely reported. However, in cellulitis, the causative microorganism is rarely identified, and some cases of E. coli cellulitis could be unrecognized. Furthermore, classical risk factors for gram-negative sepsis are characterized by a state of leucocyte dysfunction which could explain the possibility of a severe, even lethal, course of gram-negative cellulitis. Therefore, the occurrence of cellulitis in patients with risk factors should prompt attempts at isolating the pathogenic microorganism, and a broad spectrum of antibiotic therapy should be initiated.

Aged↗
PubMed1992

[Histopathologic features of opportunistic infections of the small intestine in acquired immunodeficiency syndrome].

The frequency of the opportunistic infections of the duodenum in AIDS patients was determined by way of histologic study in 207 patients between January 1987 and June 1991. All cases had serial paraffin sections, run through HES, PAS, Giemsa, Brown-Brenn, and Zieh-Neelsen stains, and 20 cases had in addition cytologic and electron microscopic study. 63 patients had opportunistic infections (10 cryptosporidiosis and 2 isosporiasis; 12 mycobacterial enteritis; 15 CMV enteritis; 7 candidosis; 7 intestinal microsporidiosis confirmed by electron microscopic examination; 12 Giardiasis; 3 duodenal leishmaniasis; 1 intestinal cryptococcosis). Multiple concurrent infections were noted in 6 cases. A mild to severe villous atrophy was observed in 28 cases, associated with opportunistic infection. A patchy distribution of pathogen agent was noted in 34 cases, and 37 cases were associated with oesophagal candidosis. This study points out the value of histologic examination of intestinal biopsy for the diagnosis of systemic infections as well as of unusual parasitosis, and the necessity for multiple endoscopic biopsies because of the frequent patchy distribution of pathogens.

AIDS-Related Opportunistic Infections↗
PubMed1992

Multicentric reticulohistiocytosis. Immunohistological and ultrastructural study: a pathology of dendritic cell lineage.

A case of multicentric reticulohistiocytosis is presented with extensive immunohistochemical study of the infiltrate in both paraffin and cryostat sections. Factor XIIIa dermal dendrocyte marker was demonstrated in the cytoplasm of histiocytes, which has not been reported previously in this disease. In addition, the S100 protein stained positive. This immunophenotyping study suggests a dermal dendrocyte lineage with an unusual expression of S100 protein.

Dendritic Cells↗