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Biomedical subjects

C Prados

Publications and source records attributed to C Prados.

At least 55 records · Page 3Linked to original sources
PubMed1994

[3 nonidiopathic forms of bronchiolitis obliterans organizing pneumonia].

Bronchiolitis obliterans organizing pneumonia is the most serious disease of the bronchioli. An idiopathic form of the disease important for differential diagnosis in incipient forms of pulmonary fibrosis has been reported in the literature, along with other forms associated to drug use, infections, and collagen and localized diseases. We describe 3 patients with bronchiolitis obliterans organizing pneumonia, one associated with rheumatoid arthritis and consumption of gold salts, one with HIV infection and one localized form associated with pulmonary hydatidosis.

Acquired Immunodeficiency Syndrome↗
PubMed1994

[The predictive parameters in the response to almitrine treatment].

Almitrine bimesylate (AB) improves hypoxemia in an undetermined number of patients with respiratory failure. Our objective was to try to identify the patients likely to benefit from this treatment. We undertook a double blind study of AB (50-100 mg/day) vs placebo in 21 randomly chosen patients diagnosed as having chronic obstructive bronchitis who were receiving oxygen therapy in the home. The study lasted 3 months (T0 to T3). PaO2 rose from 51 +/- 5.3 to 58.5 +/- 10 mmHg (6.8 +/- 0.7 to 7.8 +/- 1.3 Kpa) in the 12 patients taking AB (p < 0.05). The remaining gasometric variables and results of functional respiratory exploration were unchanged. The 7 patients receiving AB who were defined as responding-whose PaO2 rose more than 5 mmHg (0.66 Kpa)-presented T0 values lower than those of the 7 non-responding patients in the same group, with respect to CO2 occlusion pressure, mean inspiratory flow and minute ventilation for both air and CO2. These variables can serve as predictors for gasometric response to AB.

Aged↗
PubMed1994

Breathing pattern and central ventilatory drive in mild and moderate generalised myasthenia gravis.

BACKGROUND: Myasthenia gravis is a specific autoimmune disease characterised by weakness and fatigue. Respiratory muscle weakness has been studied using the determination of maximal respiratory pressures, but the response of respiratory centres is not well characterised. This study was undertaken to determine the breathing pattern and the central ventilatory drive in patients with mild and moderate generalised myasthenia gravis. METHODS: Twenty four patients with myasthenia gravis were studied, divided into two groups. Group 1 included 13 subjects (eight women and five men aged 23-64) with mild generalised myasthenia gravis, and group 2 was composed of 15 patients (11 women and four men aged 23-69) with moderate generalised myasthenia gravis. A control group comprised 15 healthy persons with a similar age and sex distribution. Spirometric measurements and maximal respiratory pressures were performed under basal conditions in all subjects, and the rate and depth of breathing and the inspiratory occlusion pressure in the mouth in the first 0.1 second (P0.1) were measured. RESULTS: No difference was detected for parameters of breathing pattern between patients in group 1 and control subjects, although P0.1 was higher in those in group 1. Subjects in group 2 had a lower tidal ventilation, shorter inspiratory time, and a higher frequency with a higher P0.1 than control subjects. CONCLUSIONS: Mild myasthenia gravis causes increased neuromuscular drive with a normal breathing pattern. Moderate myasthenia gravis is characterised by a more rapid shallow breathing pattern.

Adult↗
PubMed1994

Nasal CPAP during wakefulness increases intraocular pressure in glaucoma.

Few important side-effects of nasal continuous positive airway pressure (nCPAP) have been reported. No increase of intraocular pressure (IOP) complicating this treatment has previously been described. The goal of our study was to analyse the influence of nCPAP on IOP. We evaluated 18 patients previously diagnosed as having glaucoma and 22 normal subjects. nCPAP was used during wakefulness, at +12 cmH2O for 15 min. The results showed that nCPAP significantly increases IOP in patients with glaucoma (before nCPAP 20.3 +/- 6.3 mmHg) (mean +/- SEM); after nCPAP 22.3 +/- 5.7 mmHg. We believe that nCPAP might be relatively contraindicated in difficult to manage glaucoma patients, if these results are corroborated.

Female↗
PubMed1994

Dissection of ascending aorta. A new cause of alveolar hemorrhage?

Alveolar hemorrhage is an entity caused by different etiologies. We report the case of a male who was admitted in our Service due to hemoptysis secondary to an alveolar hemorrhage diagnosed by chest X-ray and fiberoptic bronchoscopy. Thirty six hours after the admission the patient died and his necropsy showed dissection of ascending aorta and alveolar hemorrhage.

Aortic Dissection↗
PubMed1994

[CT-guided fine-needle thoracic aspiration puncture. Its cost effectiveness and complications].

OBJECTIVE: To study the profitability and complications of the puncture aspiration with thoracic thin-needle (PATTN). METHODOLOGY: The results of 160 PATTN, performed under TC control in 131 men and 29 women, average age 61.24 +/- 15.17 years were analyzed. The diagnosis obtained by PATTN was compared with the definitive diagnosis made with biopsy (bronchial, thoracotomy, or mediastinoscopy), the evolution or response to treatment, or at autopsy. Factor related to greater diagnostic reliability and risk of pneumothorax were analyzed. RESULTS: For the diagnosis of non-tumoral pathology, the technique achieved a sensitivity (S) of 90 percent, specificity (E) of 96.06 percent, and reliability (F) of 91.71 percent, while in malignant processes, S 72.4 percent, E 100 percent and F 88.52 percent, with a histological correlation of 72.72 percent in the first case and 68.80 percent in the second. The localization in superior lobes, radiological pattern of multiple or cavitied nodules, and size > 2 cm were identified as factors which significantly increased reliability. Pneumothorax was produced in 24 cases (15 percent) and was more common in patients diagnosed of COPD, with a lesion < 2.1 cm, and not attached to the pleura. CONCLUSIONS: The PATTN offers considerable profitability for the diagnosis of thoracic lesions of any localization and nature, at low costs and with few serious complications.

Adolescent↗
PubMed1993

[Idiopathic pulmonary fibrosis: new diagnostic and therapeutic perspectives].

Idiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology affecting alveolo-interstitial structures. It is clinically characterized by progressive dyspnea and dry cough. In the physical exploration, crakles at the pulmonary bases and acropachies are usually detected. Its diagnosis has been a major clinical problem. Currently, a definitive diagnosis can be established with high resolution computerized axial tomography, bronchoalveolar lavage and open pulmonary biopsy. The next clinical problem is the assessment of activity, since it allows to differentiate subsidiary patients for receiving treatment. The description of new therapeutical alternatives has brought new perspectives in the management of these patients. Corticotherapy associated to immunosuppressors has allowed to reduce side effects and to obtain dramatic improvements. Lung transplantation, currently under study, will be the therapy of the future.

Female↗
PubMed1993

[Prevention of tuberculosis infection].

Tuberculosis (TB) is a disease caused by a mycobacterium, whose incidence has increased in the past years. This increase is related to the adquired immunodeficiency syndrome (AIDS). Due to its high prevalence, Spain is considered a developing country. The tuberculous infection depends on the degree of functionality of the alveolar macrophages that stimulate the lymphocytes and isolate the bacillus. The infection by mycobacterias can be quantified by means of the cutaneous reaction against tuberculin and mantoux, allowing us to select the subjects that must receive prophylaxis. For its correct interpretation, it is currently recommended to avoid BCG vaccination of children, except in countries with high prevalence of TB.

BCG Vaccine↗