PubMed Health⌕ Search

Biomedical subjects

C Prados

Publications and source records attributed to C Prados.

66 records · Page 4Linked to original sources
PubMed1992

[Bronchoalveolar lavage in respiratory pathology].

Bronchoalveolar lavage (BAL) offers great opportunities in the study of pulmonary diseases. It is safe and noninvasive technique, with similar possibilities than other invasive diagnostic methods and allo-wind repetitions. With the obtained sample, we can assess what happens at the bronchial level as well as the alveolar structures. The introduction of new study methods has increased its profitability in several respiratory pathologies: analysis of tumoral markers in lung cancer, monoclonal antibodies in histiocytosis X, and so on. The BAL can be considered a technique of diagnosis, follow-up, prognosis and evaluation in pulmonary diseases.

Adult↗
PubMed1992

[Clinical study of 20 cases of bronchial carcinoid].

We present a retrospective study of twenty patients in whom bronchial carcinoids, and five, peripheric. One case met the criteria of atypical carcinoid. The mean age of presentation was 46.66 +/- 17.07 years (15-76), with predominance of the female gender (3:2). Twenty per cent of patients were asymptomatic and in the remainder, the diagnosis suffered an average delay of 19 months since the appearance of symptoms. Such symptoms were cough (50%), recurrent pneumonias (40%), fever (35%), hemoptysis (35%), thoracal pain (30%), carcinoid syndrome (10%) and consumptive syndrome (5%). The radiology showed lobular or segmentary atelectasis (40%), nodule/mass (30%), lobular or segmentary consolidation (20%), obstructive pneumonitis (5%) and atypical pleural effusion (5%). Direct endoscopic vision offered a sensitivity of 84.6%, while transbronchial biopsy, just 69.2%. Metastasis in mediastinal, suprarenal, thyroid and brain gangliar chains were detected.

Adolescent↗
PubMed1990

[Incidence of epidermoid cancer of the esophagus in Asturias (1975-85)].

We present the incidence the esophageal squamous cell carcinoma in Asturias, based on the review of the clinical histories of eleven years (1975-85). Of 356 total cases, 92.4% were male patients and the remaining 7.6% females; the relation M:F was 12.2:1. Mean age at the time of diagnosis was 59.4 +/- 9.6 for males and 70 +/- for females. Total annual incidence was 2.8 +/- 0.8 cases/10(5) + population/year. Maximal annual incidence was registered in 1981: 1.1 cases/10(5) population/year. Asturias has eight health districts; those with highest incidence were mining areas: Mieres, Cangas de Narcea and Riaño. Compared to that of some developing countries, the incidence of esophageal cancer in Asturias is low, similar to that in European countries (except France) and white population of the USA; there is an aggregation of cases in males living in mining areas.

Adolescent↗
PubMedDate not supplied

The use of mouth occlusion pressure to evaluate the effect of an initial inhalation of nebulized saline in methacholine challenge.

BACKGROUND: In spite of standardization of bronchial provocation tests, some methodological aspects yet are controversial. The role of saline solution inhalation is questionable. The measurement of mouth occlusion pressure 0.1 seconds after the onset of inspiration (P0.1) is a good means of detecting a response from bronchoprovocation tests. OBJECTIVE: We investigated the value of an initial challenge with nebulized saline in subjects undergoing methacholine challenge. METHODOLOGY: Eighty-four consecutive patients clinically suspected of bronchial asthma were studied. Bronchial methacholine challenge was performed by Chatham method. P0.1 before and three minutes after saline solution inhalation were determined by the method of Whitelaw. RESULTS: There was no significant P0.1 change following the inhalation of the initial dose of nebulized saline either in those subjects who went on to produce a 20% decrement in FEV1 following a standardised methacholine challenge test, or in those subjects who proved to be non-reactors. CONCLUSIONS: We shown that no modifications are present in respiratory center function when it is assessed by measurement of mouth occlusion pressure after saline solution inhalation in methacholine challenge. This may be another reason why saline solution challenge should be omitted from bronchoprovocation challenge.

Administration, Inhalation↗
PubMedDate not supplied

Value of the peak expiratory flow in bronchodynamic tests.

OBJECTIVE: To determine the accuracy of the peak expiratory flow (PEF) as an alternative parameter to the forced expiratory volume at first second (FEV1) in the bronchodynamic tests. METHODOLOGY: We studied 84 patients, 53 males and 31 females, with average age 46 +/- 13 years, as clinic suspects of bronchial asthma. PEF was determined with a "mini-Wright peak flow meter" and a spirometry was obtained. Based on the results, 44 subjects were classified under group 1 (FEV1/FVC < 70% and FEV1 < 80% of theoretic value) and subjected to a bronchodilator test. While in group 2 subjects (normal spirometry), a methacholine challenge was performed. During each procedure, PEF readings were obtained before FEV1 determination. The usefulness of the PEF for the diagnosis of reversibility or bronchial obstruction with respect to the FEV1 was assessed in both groups. RESULTS: In the bronchodilator tests, a cut-off point was found for the increase in the PEF > 18%, which showed a sensitivity of 85%, specificity of 79%, positive predictive value of 77% and negative predictive value of 86%, with respect to an increase in the FEV1 > 15%. In the methacholine challenge, a decrease in the PEF > 12% only achieved a sensitivity of 74% and specificity of 71%. CONCLUSION: Peak expiratory flow may be an useful parameter in bronchodilator tests. However, it should not be used in methacholine challenge.

Adolescent↗