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Biomedical subjects

C Raschka

Publications and source records attributed to C Raschka.

At least 73 records · Page 4Linked to original sources
PubMed1995

Significantly lower prevalence of Helicobacter pylori in uremic patients than in patients with normal renal function.

The objective of the study was to evaluate the prevalence of Helicobacter pylori in patients with different degrees of renal function. Two hundred and twenty consecutive patients requiring gastroscopy for upper intestinal symptoms were enrolled in the study: group I (normal renal function, n = 127), group II (chronic renal failure, creatinine clearance > 5 < 90 ml/min, n = 59), and group III (hemodialysis therapy, n = 34). On endoscopy, biopsy specimens were taken for analysis of H. pylori infection by urease test and histology. The prevalence of H. pylori in patients with renal dysfunction proved to be significantly lower than that in patients with normal renal function (22.6% vs 37%, P < 0.05). The incidence of ulcer disease in patients with normal renal function was higher than that in uremic patients (14.2% vs 10.8%, not significant). These findings indicate that uremic patients seem to be partly protected against H. pylori infection.

Biopsy↗
PubMed1995

Helicobacter pylori eradication reduces the rate of rebleeding in ulcer hemorrhage.

To evaluate whether eradication with omeprazole and amoxicillin results in a reduction of ulcer recurrence and rebleeding in patients with Helicobacter pylori-associated duodenal ulcer hemorrhage, patients with upper gastrointestinal hemorrhage from duodenal ulcers with stigmata of recent hemorrhage, a drop in hemoglobin level of more than 2 g/dL, and documented H. pylori infection (by rapid urease test and histologic findings) were randomly assigned to receive omeprazole, 40 mg every day, and amoxicillin, 1 g twice a day, (Group A) or omeprazole alone, 40 mg every day, (Group B) for 2 weeks. No maintenance antiulcer therapy was given. Patients underwent a second endoscopy 4 weeks after completion of therapy and were followed for 1 year. Endoscopy was performed again at the end of 1 year. All patients showed ulcer healing 4 weeks after completion of therapy. H. pylori eradication rates were 83% (Group A) and 5% (Group B) (p < .001). Ulcer recurrences were significantly lower in Group A (3/29 or 10%) than in Group B (9/22 or 41%; p < .05). Comparison of Group A patients with eradication and Group B patients without eradication also revealed a significant difference in rates of ulcer relapse (1/24 or 4% versus 9/21 or 43%; p < .01). Rebleeding occurred significantly less often in the dual therapy group than in the omeprazole group (0/29 versus 6/22 or 27%; p < .01). Eradication of H. pylori significantly reduces the rates of ulcer recurrence and rebleeding in patients with duodenal ulcer bleeding. Dual therapy with omeprazole and amoxicillin should be considered in all H. pylori-positive patients with hemorrhage from duodenal ulcers.

Adult↗
PubMed1995

[Etiological accident types and recommendations for prevention in basketball].

The study is based on 128 basketball accidents. The following accident types were discovered: ankle sprains 54.7%, handling the ball (saving and catching) 15.6%, knee-joint-distorsions 10.2%, collisions, blows and kicks 11.7%, falls 3.9%, spontaneous damage of muscles and tendons 1.6% and getting hurt because of the equipment in the gym 2.3%. Prophylactic precautions might be physiological or synthetic taping, proprioceptor training and preventive sports medical checkups.

Ankle Injuries↗
PubMed1994

[Frontal sinus impression fracture as a collision sequelae in football].

4 soccer accidents, causing the rare case of impression fracture of the frontal sinus, are introduced as soccer-specific lesions, which are caused by head-to-head collisions, being due to heading-maneuvers. Mostly the right frontal sinus was hurt. The indication for an operation is the obvious dislocation of the osseous fragments. Primary intentions for an intervention are the precise reconstruction of the anterior wall of the frontal sinus because of esthetic reasons and a permanent drainage in order to avoid late complications as for instance mucopyoceles, if the infundibulum has been damaged. The therapy of choice is the osteoplastic frontal sinus operation, using a bicoronary incision.

Adult↗
PubMed1994

[Pronounced flush symptoms in carcinoid syndrome without liver metastases].

The case of a 78 years old patient with impressive flush symptoms is reported. 5-Hydroxyindoleacetic acid and serotonin were elevated. The responsible pathomorphological structure is a 8 x 4.5 x 6 cm ileocaecal neoplasm. Pre-, intra- and postoperatively liver metastases could not be detected during a 18 month period. After surgery of the carcinoid flush disappeared, so that the tumour seize resulting in enormous secretion of metabolites with endocrine activity should be claimed responsible for causing this symptom.

Aged↗
PubMed1993

[Sports anthropological knowledge of relationships between individual hormone levels and anthropometric measuring values].

As a tentative investigation of morpho-endocrinology, 92 male and 18 female long-distance runners (ages 21 to 72) were measured according to the standard anthropological techniques. 66 anthropometric parameters, the colours of hair and eyes were recorded. Seven growth factors were derived by means of factor analysis. The levels of 13 hormones were measured and morphological and endocrinological parameters were compared by means of correlation coefficients. So human growth hormone showed correlations to macrosomia and hyperplastic robustness. Estradiol was primarily related to the more feminine features of men, but also to leanness and slenderness of women. Testosterone exhibited significant correlations to mesomorphy and masculinity of males and leptomorphism and strength of females. Both sexes with higher insulin levels seemed to be more fat. Thyroxine (T4) showed a relation to endomorphy and leptomorphism of face, whereas Triiodothyronine (T3) exhibited correlations to ectomorphy. Thyroid stimulating hormone (TSH) was paralleling mesomorphy of males and hyperplastic robustness of females. Luteinizing hormone (LH), Follicle-stimulating hormone (FSH) and Prolactin were related to microsomia and hypoplasia. The T4 levels of the dark-haired athletes were significantly higher than the levels of the bright-haired. Several correlations between morphology and hormonal status have been shown, which may be interpreted as a permanent endocrine constitution paralleling the somatotypical body shape, outlasting growth. These correlations however should not be interpreted as causal, as further experimental studies are needed to ascertain such a link.

Adult↗
PubMed1993

[Differential determination of fibrinogen degradation products in assessment of the stages of plasma consumption in patients with infection and liver cirrhosis].

In the present study soluble fibrin complexes and fibrin(ogen) degradation products are determined in patients with sepsis and liver-cirrhotic simultaneously by means of FM-Test, FDP-Kit and SCT in order to detect the different and early phases of disseminated intravascular coagulation. According to the possible configuration of test results 43 patients (sepsis n = 23, liver cirrhotic n = 20) could be grouped in 4 phases. The FDP-concentrations and the FM-Test-result appear to be independent from one another. A positive FM-Test was found at least once in 35% of patients with liver-cirrhotic and 26% of patients with sepsis. The correlation coefficient for the two FDP-Tests (FDP-Kit and SCT) was r = 0.97 (p < 0.001) for liver-cirrhotic and r = 0.98 (p < 0.001) for sepsis.

Disseminated Intravascular Coagulation↗
PubMed1992

[Body fat compartment and its relationship to food intake and clinical chemical parameters during extreme endurance performance].

The purpose of this study was to examine the changes of the fat compartment and its relations to the corresponding blood chemistry and nutritional parameters of 55 participants of an ultra long distance run of 1000 km which consisted of 20 daily runs of 50 km. During the whole event the weight showed a falling tendency, significantly paralleling the cholesterol levels. In the middle of the run the values did not change any longer. The fat mass and all skinfolds and circumferences showed a continuously falling tendency. Only the thigh-skinfold initially grew and came down from the 4th day on. The serum blood concentrations of cholesterol and triglycerides of both sexes were decreased until the 6th and 8th day. Then a distinct increase was observed, but the initial values were not restored. The average daily energy intake of the men (women) was 4260 (3033) kcal/d, the average nutrient intake being 602.7 (431.5) g carbohydrates/d, 146.5 (103.3) g fat/d, 53.1 (38.4) g saturated fatty acids/d, 43.1 (31.3) g monounsaturated fatty acids/d, 25.3 (17.2) g polyunsaturated fatty acids/d and 382.8 (279.1) mg cholesterol/d. The correlations between the cumulative fat and food-supplies on one hand and the decrease of the anthropometric measurements of fatness on the other are negative, hence body fat mass followed closely total energy and fat intake.

Adult↗
PubMed1991

[The body muscle compartment and its relationship to food absorption and blood chemistry during an extreme endurance performance].

The purpose of the study was to examine the changes of the muscle's fat-free compartment and its relation to the corresponding biochemical and nutritional parameters of 42 men and 13 women, the participants of an ultra long-distance run of 1000 km (20 days of daily running 50 km). The muscle-fractions initially increased, decreased in the middle phase, and remained stable for the rest of the run. Significant changes of the fat-free weight were registered from the 11th day on, the LBM decreasing until the middle of the distance; then the lean body mass enlarged. All the muscle-circumferences were reduced with the exception of the thigh, which grew, paralleling the CK/CKMB-concentrations, this phenomenon being due to the high mechanical stress of the lower extremities. The biochemical parameters exhibit a strain-related reaction of adaptation within the initial 6 days, the hormones and protein-concentration increasing in the beginning and falling from the third day on, uric acid and CK/CKMB-activity decreasing from the 6th day on. The consecutive parallel reduction of both uric acid, urea, and muscle measurements might be seen as a special endurance-related clearance-mechanism of potential toxicants. The negative relationship between the changes of muscle measurements and the cumulative protein intake and the catabolic constellation of the clinical-chemical values might suggest that the absolute protein intake of 1.7 g/kg body mass should be increased in order to diminish the loss of musculature during an ultra-long distance run.

Absorption↗
PubMed1991

[Changes in foot dimensions during extreme endurance running].

55 (including 13 women) of 110 starters of a 1000-km-ultra long distance run reached their goal after 20 days of daily running 50 km. As a consequence of the burden of running 500 km the flat feet form is diminished, which might be caused by an increased reactive muscular tonus. The increase of foot length and breadth measures between the 9th and 16th day, however, demonstrates the opposite effect, when a "physiological limit" of circa 500 km is exceeded.

Anthropometry↗
PubMedDate not supplied

[Epidemiology and chrono-epidemiology of distal radius fractures].

The frequency of distal radius fractures of patients treated in the outpatient clinic of the Herz-Jesu-Krankenhaus between Jan. 1997 and Dec. 1999 were evaluated retrospectively. Records of 366 patients (m: 132, f: 234) were assessed. The frequency of distal radius fractures was fitted to a cosine model using non-linear regression in order to detect a circadian or circannual rhythm. The goodness of fit was assessed by means of the F statistics and the coefficient of determination r2. Moreover, spectral analysis was performed. In 1997 135, in 1998 119, and in 1999 112 distal radius fractures were treated. The mean age of the patients was 40.3 ys. (women: 48.8; men: 25.3). The extended wrist was the most common position during Trauma, Accidents at home (41%), during spare time activities (23.8%), and during physical activities (21.6%) were more frequent than accidents during working hours (12.5%) or traffic accidents (1.1%). The latency for definite surgical treatment in our clinic was 8.5 hours (minimum: 15 min; maximum: 7 days and 14 hours). A significant cosine model could be fitted for a period of 24 hours (r2 = 0.82) with a maximum at 15.00 hours. Spectral analysis revealed an ultradian rhythm of approximately 12 hours in addition to the circadian periodicity. No significant circannual model could be fitted (r2 = 0.2), although a slight increase of frequency was found during May and June. In conclusion, the frequency of distal radius fractures shows a clear circadian but no circannual periodicity.

Accidents↗