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Biomedical subjects

C T Nagoshi

Publications and source records attributed to C T Nagoshi.

At least 37 records · Page 2Linked to original sources
PubMed1990

Assortative mating for cultural identification as indicated by language use.

Persons of Japanese ancestry from Hawaii who marry within their own racial/ethnic group show a significant degree of homogamous assortative mating for "pidgin" and for standard English usage, variables reflective of important cultural differences in Hawaii. Persons of Japanese ancestry who married persons of other racial/ethnic groups had less exposure to pidgin in their parental homes and were less likely to speak this dialect of English. Sibling-spouse analyses suggested that assortment for such language use is entirely due to social homogamy rather than active phenotypic assortment.

Adult↗
PubMed1990

Twin resemblances in cognitive abilities in an Egyptian sample.

Thirty-six pairs of monozygotic (MZ) twins, 24 pairs of same-sexed dizygotic (DZ) twins, and 33 pairs of opposite-sexed DZ twins 12 to 19 years of age were tested in Minia, Egypt, on a battery of cognitive abilities tests. For most of the tests and composite scales, DZ resemblances were higher than typically found in Western samples and not significantly different from MZ resemblances. MZ resemblances were generally lower than typically found in Western samples. These results were discussed in terms of the influence of cross-cultural differences in degree of social stratification and assortative mating.

Adolescent↗
PubMed1990

Familial transmission of alcohol use norms and expectancies and reported alcohol use.

Members of 183 families (biological parents and one adult offspring) completed questionnaires on their quantity and frequency of alcohol use, what they would consider a "normal" quantity-frequency of alcohol use, "problem" quantity-frequency of use, flushing after alcohol use, and other expected physiological and subjective responses to alcohol. Within individuals, own quantity-frequency of alcohol use was moderately negatively correlated with flushing after one drink or less ("fast flushing"), but more highly positively correlated with judged normal alcohol use and with expected subjective effects. Spouse resemblances were low for quantity-frequency of alcohol use and flushing, but high for alcohol use norms and expected physiological and subjective responses. Parent-offspring resemblances were low to moderate for own alcohol use and flushing, but moderate to high for expected physiological and subjective effects. These results were discussed in terms of the effects of genetically transmitted flushing after alcohol use and culturally transmitted alcohol norms and expectations on alcohol use.

Adult↗
PubMed1989

Cardiovascular responses to cocaine placebo in humans: a preliminary report.

Cardiovascular responses after placebo-cocaine injections were in the same direction as the effect of cocaine iv in 22 male volunteers. Subjects received iv placebo in a room where they had been given repeated doses of iv cocaine. The placebo response consisted of an increase from baseline values of systolic and diastolic blood pressure and pulse rate. The control group, 8 subjects, which was not exposed to a conditioning phase, showed a smaller increase in the pulse rate and systolic blood pressure after the placebo injection. The results, in accordance with animal literature, suggest the existence of cocaine-conditioned effects in humans.

Adult↗
PubMed1989

Characteristics of emigrants from Hawaii.

As part of an ongoing study on young adult psychological and social development, data were obtained through parental reports on the present residences and educational and occupational attainments of 718 present or former residents of Hawaii (average age 31 years). These subjects, as well as their parents, had been tested between 1972 and 1976 on measures of cognitive abilities and personality. The extent of emigration to the mainland in this middle to upper-middle class sample was over 40%. On average, former Hawaii residents now living on the US mainland were of higher intelligence and educational background than their counterparts still living in Hawaii. Differences were also found for number of children, cross-ethnic marriages, and occupational attainment (males only). In addition, parents of US mainland residents scored significantly higher on measures of cognitive abilities and education than parents of current Hawaii residents.

Adult↗
PubMed1989

Long-term repeatability of human alcohol metabolism, sensitivity and acute tolerance.

Thirty-eight subjects in the Colorado Alcohol Research on Twins and Adoptees (CARTA) were brought back between 3 and 39 months after their initial testing to be retested on a shortened version of the standard CARTA procedures. As before, subjects were given a dose of ethanol (0.8 g/kg) calculated to bring their blood alcohol level (BAL) to near 100 mg/dl, but no topping doses were administered in the retests to maintain BALs near peak for 3 hours, as was done previously. Repeatability (test-retest correlation) for alcohol clearance rate was near zero, repeatability for time to peak BAL was 0.36 and that for peak BAL was 0.50. Repeatabilities of prealcohol baseline scores were generally high (median 0.55) for the shortened battery of physiological, motor coordination, perceptual speed and reaction time measures. Repeatabilities were near zero for sensitivity scores (median 0.02) and were low for acute tolerance scores (median 0.10) and perceived intoxication (median 0.27). These findings are highly consistent with an earlier report on repeatabilities of responses to alcohol over a 1-month time interval.

Adoption↗
PubMed1988

One-month repeatability of emotional responses to alcohol.

Thirty-four subjects in the Colorado Alcohol Research on Twins and Adoptees (CARTA) were brought back between 30 to 60 days after their initial testing to be retested on all the CARTA procedures. As before, subjects were given a dose of ethanol (0.8 g/kg) calculated to bring their blood alcohol concentration (BAC) to near 0.10 g/dl. Additional doses were given at the end of each of the next 2 hr to maintain their BAC near peak for approximately 3 hr. During both testings, subjects' self-reports of their emotional responses and perceived intoxication following alcohol dosing were only minimally correlated with their alcohol metabolism parameters and reported average level of alcohol use. Repeatabilities (test-retest correlations) for subjects' self-reports of positive affect and of intoxication following alcohol dosing were consistently high, in contrast to earlier reports of minimal repeatabilities for alcohol metabolism and responses to alcohol on physiological, motor coordination, reaction time, and perceptual speed measures. Tester ratings of the subjects' levels of intoxication were also moderately stable between the two testings.

Adoption↗
PubMed1988

Judgments of "normal" and "problem" alcohol use as related to reported alcohol consumption.

We obtained alcohol use data and judgments of individual ("What do you think?") and cultural ("What do people in general think?") norms for normal and problem quantity and frequency of alcohol use, as well as ratings of whether particular alcohol-related behaviors indicated a drinking problem, from 928 adult respondents who were members of Hawaii's five major racial/ethnic groups [Chinese, European (Caucasian), Filipino, Hawaiian/Part-Hawaiian, and Japanese ancestry]. As compared with older survey data (but consonant with recent survey data), Hawaiians have substantially increased in alcohol use, as have Filipinos (if they drink at all; a high proportion are abstainers), and to a lesser extent, Japanese. Chinese remain very low in alcohol use, while Caucasians have relatively decreased in use. Alcohol use norms (especially of own judged normal use) vary across sexes and ethnic groups and are predictors of consumption both within and across groups. Family resemblances are substantial with regard to alcohol use category (present users, former drinkers, abstainers). Among present users, family resemblances are often significant with regard to amount used; resemblances are more substantial between mothers and offspring than between spouses or between fathers and offspring. There were small but significant ethnic group differences in the number of specific behaviors judged to be indicative of a drinking problem, with the groups reporting the highest mean alcohol consumption (Caucasians and Hawaiians/Part Hawaiians) also indicating more behaviors, particularly pathological as opposed to celebratory behaviors, as being problematic.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1988

Familial transmission of alcohol consumption and the flushing response to alcohol in three Oriental groups.

Multivariate path analysis was used to examine the etiologies of variation and covariation of flushing after alcohol use in nuclear families of Korean, Taiwanese, Japanese and Caucasian ancestries. Phenotypic variances and covariances were partitioned into familial (additive genetic and common family environment) and environmental components. Although alcohol consumption and flushing varied greatly among the different groups, familialities, estimated from components of mother, father and at least one child, were remarkably similar. The familialities for flushing were 0.48 for Japanese, 0.56 for Koreans and 0.35 for Taiwanese; flushing is infrequent in Caucasians and thus was not analyzed. Familialities were lower for consumption, but like flushing, were consistent across ethnic groups (Japanese, 0.27; Koreans, 0.24; Taiwanese, 0.15; Caucasians, 0.28). The genetic correlation between flushing and alcohol consumption was high. Thus, to the extent that flushing influences alcohol consumption, the covariance is most likely genetic.

Adolescent↗
PubMed1987

Influence of family alcoholism history on alcohol metabolism, sensitivity, and tolerance.

As part of the Colorado Alcohol Research on Twins and Adoptees (CARTA), 35 subjects who reported having an alcoholic parent or sibling [family alcoholism history positive (FHP)] were matched with 35 controls [family alcoholism history negative (FHN)]. All subjects were tested three times on a battery of physiological, motor, and cognitive performance tasks before the ingestion of alcohol, then were tested three more times over a 3-hr period during which their blood alcohol concentration (BAC) was brought up to and maintained at about 0.10 g/dl by an initial large dose of ethanol and subsequent topping doses. FHP subjects scored significantly lower than FHN subjects on the Raven's Progressive Matrices and on some of the cognitive tasks before alcohol ingestion. FHP and FHN subjects, however, did not significantly differ in absorption and clearance of alcohol or in sensitivity and acute tolerance scores calculated on the repeated measures. Contrary to expectations, FHP subjects perceived themselves as being more impaired by alcohol than FHN subjects, and there was little evidence to suggest that they were less sensitive to variations in BAC.

Adoption↗
PubMed1987

One-month repeatability of alcohol metabolism, sensitivity and acute tolerance.

Subjects (N = 34) in the Colorado Alcohol Research on Twins and Adoptees (CARTA) were brought back between 30 and 60 days after their initial testing to be retested on all the CARTA procedures. As before, subjects were given a dose of alcohol (.8 g/kg of body weight) calculated to bring their blood alcohol level (BAL) to near 100 mg/dl. Additional doses were given at the end of each of the next 2 hours to maintain their BAL near peak for approximately 3 hours. Repeatability (test-retest correlation) for alcohol clearance rate was near 0, with repeatabilities between .40 and .55 for peak BAL, time-to-peak BAL, average session BAL and relative volume of alcohol distribution. Repeatabilities of prealcohol baseline scores were generally high (median, .71) for the CARTA battery of physiological, motor coordination, perceptual speed and reaction time measures, but were only low to moderate for sensitivity scores (median, .27) and acute tolerance scores (median, .25) calculated on these measures. There was some evidence that repeatabilities for alcohol metabolism, sensitivity and acute tolerance were lower for women than for men.

Adoption↗
PubMed1986

Use of regression residuals to quantify individual differences in acute sensitivity and tolerance to alcohol.

Due to the problem of correlation of errors inherent in the difference or ratio scores typically used to quantify individual differences in acute sensitivity and tolerance to alcohol, it is recommended that residual scores from regression analyses be used instead for such quantification. Conceptualizations of acute sensitivity and tolerance and problems with the reliability of change scores are also discussed.

Adoption↗
PubMed1985

A cross-ethnic comparison of reasons given for using alcohol, not using alcohol or ceasing to use alcohol.

In a study that included six different racial-ethnic groups in Hawaii, the reasons given by drinkers for drinking, abstainers for not drinking and former drinkers for ceasing to drink were assessed. Although there were group differences in frequencies of endorsement of given reasons for drinking, for not drinking or for ceasing to drink, the findings of similarity were most impressive. Drinkers, abstainers and former drinkers were similar across racial-ethnic groups in their proportions of endorsement of given reasons for drinking, abstaining or ceasing to use alcohol. Although reasons for drinking varied across racial-ethnic groups, they varied much more across groups that differed in alcohol consumption independent of ethnicity, with all reasons for drinking being more often endorsed as consumption increased. In addition, the citation of more pathological reasons for drinking was associated with a greater number of drinking problems.

Adult↗