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Biomedical subjects

C Versavel

Publications and source records attributed to C Versavel.

10 recordsLinked to original sources
PubMed1986

Modifications in plasma levels of alpha macroglobulins and fibrinogen trypsin perfusion in normal rabbits and in rabbits in acute phase reaction.

During trypsin perfusions in normal rabbits and in rabbits in acute phase reaction (APR), there is no modification in cardiorespiratory functions except in the instant preceding death. The fibrinogen level decreases and fibrin is deposited in the vascular lumen. The alpha 2 macroglobulin (alpha 2 M) content diminishes more rapidly than the alpha I macroglobulin (alpha I M) content; moreover, in subjects in APR, the decrease of alpha I M is further slowed with increasing perfusion rates, whereas the decrease in alpha 2 M remains constant. All the alpha M are completely combined at death. Therefore, it can be assumed that only the hepatic filtering of the alpha I M enzyme complex is subject to saturation.

Animals↗
PubMed1979

A study of rabbit plasma progressive antithrombinic activity during acute phase inflammatory reaction and in experimental nephrotic syndrome.

1. The development of the progressive antithrombinic activity in rabbit plasma as a function of the level of the two alpha-macroglobulins in two experimental pathologies: acute phase inflammatory reaction and nephrotic syndrome, were studied. 2. In the first case, the antithrombinic activity is a result of the increased biosynthesis of plasmatic antithrombins: antithrombin III, alpha 1 antitrypsin and alpha macroglobulins. 3. In the nephrotic syndrome, this activity follows the increase in the alpha M levels, the other antithrombins having been massively eliminated from the circulation in the urine.

Animals↗
PubMed1978

[Progressive antithrombin activity in rabbit plasma. Role of alpha macroglobulins].

Immunological methods associated with a kinetic study of blood coagulation allowed us to show the influence of the 2 rabbit alpha macroglobulins on the plasma progressive antithrombin activity. This study allowed the authors to discuss the participation of the alpha macroglobulins during the fibrinoformation and to think that these proteins have an immediate antithrombin activity.

Animals↗
PubMed1977

[Metabolism of alpha macroglobulins of rabbits: study of their half-life].

Rabbit alpha-1-M and alpha-2-M labelling was carried out in vitro with 131I and in vivo with 75-Seleno-methionine in order to determine the half-life of these proteins. alpha-2-M catabolism is faster than the alpha-1-M one. This result is the same when these proteins were obtained from a plasma of a rabbit exhibiting an inflammatory reaction though their half life was shorter.

Animals↗
PubMed1977

[Isolation of alpha-1-macroglobulin (alpha 1 M) and alpha-2-macroblogulin (alpha 2 M) from rabbit blood].

A purification process of rabbit alpha 1 M and alpha 2 M from plasma was described: first the platelets, the fibrinogen, the plasminogen and the low-density lipoproteins were eliminated; then alpha 1 M and alpha 2 M were purified by gel filtration on Sephadex G 200 and by chromatography on DEAE-cellulose. These purified materials were then isotopically labeled allowing the study of the proteins metabolism.

Animals↗
PubMed1975

[Changes in the level of alpha1-macroglobulin in rats during Masugi nephritis].

Using chromatographic technique on "Sephadex G 200" associated to immunologic qualitative and quantitative techniques, the authors showed that the alpha1-macroglobulin is present in normal Rat urines. This protein is also present in urines obtained during the Masugi nephritis. The alpha1-macroglobulin concentration observed in the different urine samples is unrelated to the total proteinuria evolution. The results given allow us to discuss the mechanisms of the glomerular filtration.

Animals↗