PubMed Health⌕ Search

Biomedical subjects

C Y Tan

Publications and source records attributed to C Y Tan.

At least 37 records · Page 2Linked to original sources
PubMed1993

Cardiac and systemic complications in multicentric reticulohistiocytosis.

A 75-year-old man with a short history of cutaneous lesions of multicentric reticulohistiocytosis, preceded by a few months of a symmetrical polyarthritis is described. Within 5 months of onset of symptoms, he developed congestive cardiac failure secondary to pericardial involvement by the disease and succumbed despite therapy with cyclophosphamide and methylprednisolone. Post-mortem revealed the true extent of the disease, with nodules seen in the epiglottis and aryepiglottic folds, duodenal mesentery, pleura, pericardium and myocardium. Although the hallmarks of the disease are the papulonodular skin lesions, together with a severe, sometimes mutilating polyarthropathy, its widespread systemic nature is not often appreciated. We review five other cases in the literature with pericardial involvement and discuss aids to earlier diagnosis by synovial fluid cytology; gallium scanning is discussed as a potentially useful means of detecting the extent of systemic involvement in multicentric reticulohistiocytosis.

Aged↗
PubMed1992

Erythema multiforme reaction to patch testing.

A young woman developed erythema multiforme in association with multiple patch test reactions. Sequential patch testing revealed 2 true positive reactions (colophony and fragrance mix), and was not associated with flare of erythema-multiforme-type lesions. The development of erythema multiforme should be included in the list of possible adverse reactions to patch testing, albeit a rare occurrence.

Adult↗
PubMed1990

Speckled compound naevus.

We report a case of a localized speckled compound naevus arising within normally pigmented skin. Speckled melanocytic naevi are reviewed and the distinctive features of the case enumerated.

Adolescent↗
PubMed1989

Familial sarcoidosis: high ethnic prevalence.

We report three sisters of Irish extraction who all developed sarcoidosis. The cases emphasize both the familial and ethnic preponderance of sarcoidosis which has not been adequately emphasized in the dermatology literature.

Family↗
PubMed1986

Lichen aureus.

Explore the source record for details and available documents.

Adolescent↗
PubMed1982

Lichenoid solar keratosis--prevalence and immunologic findings.

Solar keratoses (SKs) may show basal cell liquefactive degeneration (BLD) and, when extensive, this can result in a superficial resemblance to lichen planus. The frequency of these phenomena and involvement of immune mechanisms in them have been investigated in this study. The prevalence of lichenoid keratosis (LK) was 6.1% in 212 SKs examined retrospectively and 10.7% in 28 examined prospectively. Histologic features were scored on analogue scales and their interrelationships examined. BLD could not be correlated with epidermal atypia, acanthosis, acantholysis, or inflammatory cellular infiltrate; a negative correlation occurred with parakeratosis. Immunoglobulins and/or fibrin and complement were found by immunofluorescence in 78.8% of the 28 specimens examined prospectively. Three LKs showed similar immunofluorescence findings to ordinary SKs. No circulating antibodies to epidermal structures were detected in patients with SKs. It is concluded that (1) no feature of SKs investigated predisposed to lichenoid change, (2) BLD was a frequent feature in SKs whereas full development of LK occurred much less frequently, and (3) immunoprotein deposits were not related to the development of BLD. Clinically, LKs could not be distinguished from ordinary SKs.

Fibrin↗
PubMed1982

Histamine and epidermal proliferation.

Histamine is liberated in the inflammatory reaction and has been reported to inhibit epidermal cell division in vitro. This study has investigated the effects of histamine and HI and H2 antagonists on epidermopoiesis in vivo in man. No direct stimulatory effect of histamine was detected for normal epidermis. A combination of HI antagonist (chlorpheniramine) and H2 antagonist (cimetidine) led to further increases in epidermal labelling indices in mitotically stimulated epidermis. The administration of HI antagonist alone led to a decrease in mean epidermal thickness. These data suggest that histamine release is unlikely to play a major role in the hyperplasia of inflammatory dermatoses, but that it may be possible to influence epidermal reactions via the HI and H2 receptors.

Adult↗
PubMed1982

Skin thickness measurement by pulsed ultrasound: its reproducibility, validation and variability.

The reproducibility of the pulsed ultrasound technique for the determination of skin thickness was investigated, using two independent observers. No systematic difference was found and a high correlation was obtained. Studies were also undertaken to validate the pulsed ultrasound technique as a measure of true skin thickness. Skin thickness determined in vitro was found to be greater than when in vivo determinations were made by either the pulsed ultrasound or a xeroradiographic technique, probably due to the release of in vivo tension within the dermis after excision. Skin thickness was found to increase linearly with age up to the age of 20 years and to decrease linearly with age subsequently. Differences in skin thickness between the sexes and in different sites of the body were demonstrated.

Adolescent↗
PubMed1981

Comparison of xeroradiographic and ultrasound detection of corticosteroid induced dermal thinning.

A pulsed ultrasound technique was shown to have a high degree of correlation with the established xeroradiographic method for the determination of dermal thickness both in normal skin and corticosteroid treated skin, although xeroradiography consistently gave a higher value than ultrasound. Using the pulsed ultrasound technique, an early onset of dermal thinning could be detected 2 days following treatment with creams containing 0.05% clobetasol propionate and 0.1% beta-methasone 17-valerate. The amount of dermal thinning produced by the clobetasol propionate preparation was significantly greater than that produced by cream base, clobetasone butyrate 0.05% cream and hydrocortisone 1% cream as determined by both techniques. The pulsed ultrasound technique is an accurate, noninvasive and safe method for determining dermal thickness.

Adrenal Cortex Hormones↗